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LIMS Integration Framework Model | May 2010
Contents
Abstract
Market Trend
Target Audience
Problem statement
Solution
Conclusion
References
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Abstract
Todays LIMS business applications rarely live in isolation.
The LIMS users expect instant access to all the LIMS business
functions an enterprise can offer, regardless of which LIMS system
the functionality may reside in. This requires disparate LIMS
applications to be connected into a larger, integrated solution. This
integration is usually achieved through the use of some form of
middleware. Middleware provides the plumbing such as data
transport, data transformation, and routing.
The integration of the Laboratory Information Management System
(LIMS) is a major challenge in the industry. In a pharmaceutical
company which has multiple versions of LIMS or a single version
of LIMS, the integration within the LIMS products is still under
research. Here, the ideal solution would be a systematic LIMS data
integration and cleansing of the unstructured data management
and the information management that allows storing the data
from the various LIMS operational system to a common single
LIMS repository system, from where, the user can retrieve the data
for the reporting. The proposed framework model is designed in
such a way that any type of LIMS product can be plug-in with
the proposed integration model. Here, the intelligent and generic
adaptors will help in the data push/pull operation for the seamless
integration between the different types of LIMS applications. These
adaptors can be plug-in with any types of LIMS.
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
Market Trend
The revenues in the laboratory information management systems
(LIMS) market have received a huge boost with the growing use
of these systems in various applications in mature sectors such as
pharmaceuticals, manufacturing, and IT. They are also used in
emerging sectors such as biotechnology and food and beverage. This
increased usage can be attributed to the launch of innovative LIMS
technologies and products, especially in the biotech industries. The
adoption of LIMS and the biotech companies are likely to expand
simultaneously. As biotech enterprises become successful and begin
to mimic pharmaceutical companies, they will have greater need for
LIMS integration so that they can get one common platform and
repository for all.
The Frost & Sullivan research service examines the key trends in
the LIMS market and observed that lots of research work is still
required for the LIMS integration. As the LIMS software is more
expensive to install, low research funding has become a huge
concern among LIMS companies. Most of the solution framework
of the available LIMS products in the market is based on old
technologies and the laboratories do not obtain adequate funds for
managing their data and up-gradation of LIMS, and therefore have
to manage with systems having lesser compatibility. Since these old
technology systems lack in beneficial and flexible operations, they
will reduce the efficiency of work. So for an organization it is just
impossible to maintain the multiple versions of LIMS and business
is searching for some solution for the seamless LIMS integration so
that business can integrate the multiple version of LIMS to a single
version LIMS.
Target Audience
The target audiences are from the following industries,
Pharmaceutical industry & Biotech Industry
Petrochemicals & Chemicals
Contract Research Organization
Clinical Lab
Food Industry
Others
Problem statement
Global life science organizations are under increasing pressure
to harmonize and integrate their asynchronous types of LIMS
business processes and are searching for ways to standardize on
mission-critical computing solutions for an integration of multiple
types of LIMS to a single version LIMS. The integration of LIMS
is a real challenge in industry because most of the LIMS products
which are available in the industry are the propitiatory systems.
Lots of challenges are involved in the integration of the different
LIMS business processes because the data format is different and also
unstructured works in asynchronous mode. Most of LIMS which
are available in the market are based on the old technologies and
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
most of them are also stand alone systems. It is very much difficult
to align the multiple types of source LIMS with a single target
LIMS because of unstructured data exchange and data formats. The
business is in pressure to integrate their multiple versions of LIMS
to a single version LIMS where master data as well as the transaction
data plays a major role.
Solution
Architecting LIMS integration solutions is a complex task. There are
many conflicting LIMS process rule engines and even more possible
right solutions. Most integration vendors provide methodologies
and best practices, but these instructions tend to be very much geared
towards the vendor-provided tool set and often lack treatment of
the bigger picture, including underlying guidelines, principles and
best practices. Asynchronous messaging architectures have proven
to be the best strategy for enterprise integration because they allow
for a loosely coupled solution that overcomes the limitations of
remote communication, such as latency and unreliability. The
trend towards asynchronous messaging has manifested itself in a
variety of EAI (Enterprise Asynchronous Integration) suites as
well emerging standards for reliable, asynchronous web services.
Many of the assumptions that hold true when developing single,
synchronous applications are no longer valid. What is needed
is vendor-independent design guidance and framework model
on building robust LIMS integration architectures based on
asynchronous messaging.
The LIMS integration layer of the proposed solution focused on the
Data Virtualization, discussed in section 5.1 and the data integration
techniques discussed in section 5.2.
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
and the canonical data model. The different data formats will be
translated through the source translator which will be mapped to
the target data formats C athrough the target translator and finally
the resultant data will be transformed as per the format of the target
LIMS-X. The integration and the transformation will be performed
via the canonical data model between source to the target application
so that seamless data exchanged can occur between the source LIMS
to the target LIMS. The basic steps for the above mentioned LIMS
integration are as follows:
Step-1: Data Synchronization (data mapping) between the source
LIMS to the
Step-2: Data Migration from source LIMS to the Target LIMS
Step-3: Process Integration between the source LIMS to the target
LIMS
Step-4: Data Integration between the source LIMS to the target
LIMS
Step-4: Data build-up (following Incremental & Iterative process)
The proposed protocol for the integration layer will be SOAP
(Simple Object Access Protocol).
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
Conclusion
In the proposed integration framework model, the system will be
flexible enough to add more source LIMS as and when required.
This would also help in adding new LIMS business line in future.
The target LIMS will hold both the transactional level information
at the lowest level as well as the master data so there will be no bottle
neck in generating operational or Adhoc nature reports from a single
source as and when required. The migration process will take care
the data migrate by incremental method which would bring down
the data loading time to a great extent. The proposed design acts a
single unified source of reporting for optimal performance. Due to
the integration, the licensing cost will be reduced considerably. The
number of physical servers will reduce; this would bring down the
recurring hardware and maintenance cost. So using this frame work
we can also optimize the cost to a great extent.
References
1. Worldwide Regulatory Compliance Issues in Life Science
(IDC #32690,December 2004)
2. 1Q05 Leading Indicators in Life Science s IT Spending Survey,
an IDC Report
3. Knowledge Management in Drug Discovery R&D 3rd
Millennium, Inc. February 2003
4. Laboratory Automation: Smart Strategies and Practical
Applications Donald S. Young1, University of Pennsylvania
Medical Center, 3400 Spruce St., Philadelphia, PA 19014-4283
5. Laboratory Information Management System Outlook,
Five year market analysis and technology forecast through 2008
Arc Advisory Group
6. Laboratory Automation and Information Management 32 (1996)
7-22
7. A Revolution in Agility: Business Integration Through
Service-Oriented Architecture : An Oracle White Paper Updated
August 2008
8. Enterprise Integration Patterns: Mr. Eva Shon , Software &
Systems Engineering Seminar
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
LIMS Integration Framework Model | May 2010
2010, HCL Technologies. Reproduction Prohibited. This document is protected under Copyright by the Author, all rights reserved.
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LIMS Integration Framework Model | May 2010
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