Professional Documents
Culture Documents
2014
Editorial Board
CELLULAR GENETICS
Mark Johnston,
Editor-in-Chief
University of Colorado
School of Medicine
Bruce Beutler
The University of Texas
Southwestern Medical
Center
Tracey DePellegrin
Executive Editor
Sue Biggins
Fred Hutchinson Cancer
Research Center
Cristy Gelling
Assistant Editor
Ruth Isaacson
Assistant Managing
Editor
BOARD OF SENIOR
EDITORS
Karen M. Arndt
University of Pittsburgh
Gary A. Churchill
The Jackson
Laboratory
Stanley Fields
University of
Washington
Mark Johnston
University of Colorado
School of Medicine
Orna Cohen-Fix
NIDDK, National
Institutes of Health
Bob Goldstein
University of North
Carolina at Chapel Hill
David I. Greenstein
University of Minnesota
Joseph Heitman
Duke University
Medical Center
Daniel J. Lew
Duke University
Medical Center
Piali Sengupta
Brandeis University
Yongbiao Xue
Chinese Academy of
Sciences
Loeske E. B. Kruuk
University of
Edinburgh
Lauren M. McIntyre
University of Florida
Andrew H. Paterson
University of Georgia
Saunak Sen
University of California,
San Francisco
David W. Threadgill
Texas A&M University
Trudi Schpbach
Princeton University
William T. Sullivan
University of California,
Santa Cruz
Meera V. Sundaram
University of
Pennsylvania
Mariana F. Wolfner
Cornell University
GENE EXPRESSION
James A. Birchler
University of Missouri
Jason B. Wolf
University of Bath
Michael Freitag
Oregon State
University
Naomi R. Wray
The University of
Queensland
Fei Zou
University of North
Carolina at Chapel Hill
Audrey Gasch
University of
Wisconsin-Madison
Pamela Geyer
University of Iowa
DEVELOPMENTAL
AND BEHAVIORAL
GENETICS
Michael Hampsey
Rutgers Robert Wood
Johnson Medical
School
Alan G. Hinnebusch
NICHD, National
Institutes of Health
Ann Hochschild
Harvard Medical School
COMPLEX TRAITS
Hugo J. Bellen
Baylor College of
Medicine
Terry R. Magnuson
University of North
Carolina at Chapel Hill
Joshua M. Akey
University of
Washington
Kym M. Boycott
CHEO Research
Institute
Michael W. Nachman
University of California,
Berkeley
Justin O. Borevitz
Australian National
University
Lynn Cooley
Yale University
Aaron P. Mitchell
Carnegie Mellon
University
Krista M. Nichols
NOAA Fisheries
Alain Charcosset
Institut National
de la Recherche
Agronomique
Robert J. Duronio
University of North
Carolina at Chapel Hill
Craig S. Pikaard
Indiana University
Charles H. Langley
University of California,
Davis
Mark D. Rose
Princeton University
John C. Schimenti
Cornell University
John Wakeley
Harvard University
Stephen Chenoweth
The University of
Queensland
Dirk Jan de Koning
Swedish University of
Agricultural Sciences
Ina Hoeschele
Virginia Polytechnic
Institute and State
University
Corbin D. Jones
University of North
Carolina at Chapel Hill
David I. Greenstein
University of Minnesota
Marnie E. Halpern
Carnegie Institution for
Science
Iswar K. Hariharan
University of California,
Berkeley
Abraham A. Palmer
University of Chicago
David M. Parichy
University of
Washington
R. Scott Poethig
University of
Pennsylvania
Eric U. Selker
University of Oregon
GENOME INTEGRITY
AND TRANSMISSION
Sharon E. Bickel
Dartmouth College
Monica P. Colaicovo
Harvard Medical School
Nancy M.
Hollingsworth
Stony Brook University
Andreas Houben
Leibniz Institute of
Plant Genetics and
Crop Plant Research
Neil Hunter
University of California,
Davis
James R. Lupski
Baylor College of
Medicine
Jac A. Nickoloff
Colorado State
University
Steven J. Sandler
University of
Massachusetts
Jeff Sekelsky
University of North
Carolina at Chapel Hill
Shyam K. Sharan
NCI, National Institutes
of Health
GENOME AND
SYSTEMS BIOLOGY
Charles Boone
University of Toronto
Stanley Fields
University of
Washington
David A. Largaespada
University of Minnesota
Brian P. Lazzaro
Cornell University
Jeffery F. Miller
University of California,
Los Angeles
Andrew W. Murray
Harvard University
Norbert Perrimon
Harvard Medical School
Enrico G. Petretto
Imperial College
London
Lars M. Steinmetz
European Molecular
Biology Laboratory &
Stanford University
Gary D. Stormo
Washington University
School of Medicine
David Valle
Johns Hopkins
University School of
Medicine
Daniel F. Voytas
University of Minnesota
METHODS,
TECHNOLOGY, AND
RESOURCES
Charles Boone
University of Toronto
Justin O. Borevitz
Australian National
University
George M. Church
Harvard Medical School
Oliver Hobert
Columbia University
Ann Hochschild
Harvard Medical School
Norbert Perrimon
Harvard Medical School
Jeff Sekelsky
University of North
Carolina at Chapel Hill
Jay Shendure
University of
Washington
Gary D. Stormo
Washington University
School of Medicine
David W. Threadgill
Texas A&M University
Daniel F. Voytas
University of Minnesota
STATISTICAL
GENETICS AND
GENOMICS
Ina Hoeschele
Virginia Polytechnic
Institute and State
University
Christina Kendziorski
University of
Wisconsin-Madison
Neil Risch
University of California,
San Francisco
Kathryn M. Roeder
Carnegie Mellon
University
Chiara Sabatti
Stanford University
Saunak Sen
University of California,
San Francisco
Eric A. Stone
North Carolina State
University
Nengjun Yi
University of Alabama
at Birmingham
EMPIRICAL
POPULATION
GENETICS
Daniel A. Barbash
Cornell University
David J. Begun
University of California,
Davis
James J. Bull
University of Texas at
Austin
Deborah Charlesworth
University of
Edinburgh
Anna Di Rienzo
University of Chicago
Santiago C. GonzlezMartnez
Forest Research
Centre (CIFOR-INIA)
Matthew W. Hahn
Indiana University
Lynn B. Jorde
University of Utah
Charles H. Langley
University of California,
Davis
Jeffrey G. Lawrence
University of Pittsburgh
Brian P. Lazzaro
Cornell University
Leonie C. Moyle
Indiana University
Bret A. Payseur
University of
Wisconsin-Madison
THEORETICAL
POPULATION
GENETICS
Nick H. Barton
Institute of Science and
Technology Austria
Mark A. Beaumont
University of Bristol
Joachim Hermisson
University of Vienna
Rasmus Nielsen
University of California,
Berkeley & University
of Copenhagen
Sohini Ramachandran
Brown University
Noah A. Rosenberg
Stanford University
Yun S. Song
University of California,
Berkeley
Wolfgang Stephan
University of Munich
Marcy K. Uyenoyama
Duke University
Lindi M. Wahl
Western University
Jeff D. Wall
University of California,
San Francisco
PRIMERS
Elizabeth A. De Stasio
Lawrence University
PERSPECTIVES
H. Allen Orr
University of Rochester
Adam S. Wilkins
Humboldt University
of Berlin
REVIEWS
Outi Savolainen
University of Oulu
Oliver Hobert
Columbia University
Daniel M. Weinreich
Brown University
Jasper Rine
University of California,
Berkeley
Stephen I. Wright
University of Toronto
Michael Turelli
University of California,
Davis
Mark Johnston
Editor-in-Chief,
GENETICS
ON THE COVER In 2014, Zimin et al. and Wegrzyn et al. reported the 23-Gb reference
sequence of the loblolly pine, the largest genome sequenced and assembled to date.
Image courtesy of Ron Billings, Texas A&M Forest Service. See Zimin et al. , Genetics
196:875890 and Wegrzyn et al. , Genetics 196:891909.
Thank you for providing a fair and competitive platform to publish our
research. I was very pleased with the review process. Our editor Karen
Arndt did an excellent job. Unlike other editors, she read the paper and,
along with the reviewers comments, gave us valuable suggestions on
improving the manuscript. Rarely do we see such detailed reviews these
days. We are very pleased with the end result as the manuscript reads
much better. My experience with other journals is not the same; they
merely send the reviews back with a generic rejection/revisions letter.
Munira Basrai
National Cancer Institute, NIH
ABSTRACT Genomic stability, stress response, and nutrient signaling all play
critical, evolutionarily conserved roles in lifespan determination. However, the
molecular mechanisms coordinating these processes with longevity remain
unresolved. Here we investigate the involvement of the yeast anaphase
promoting complex (APC) in longevity. The APC governs passage through
M and G1 via ubiquitin-dependent targeting of substrate proteins and is
associated with cancer and premature aging when defective. Our two-hybrid
screen utilizing Apc5 as bait recovered the lifespan determinant Fob1 as
prey. Fob1 is unstable specifically in G1, cycles throughout the cell cycle in a
manner similar to Clb2 (an APC target), and is stabilized in APC (apc5CA) and
proteasome (rpn10) mutants. Deletion of FOB1 increased replicative lifespan
(RLS) in wild type (WT), apc5CA, and apc10 cells, and suppressed apc5CA
cell cycle progression and rDNA recombination defects. Alternatively, increased
FOB1 expression decreased RLS in WT cells, but did not reduce the already
short apc5CA RLS, suggesting an epistatic interaction between apc5CA and
fob1. Mutation to a putative L-Box (Fob1E420V), a Destruction Box-like motif,
abolished Fob1 modifications, stabilized the protein, and increased rDNA
recombination. Our work provides a mechanistic role played by the APC to
promote replicative longevity and genomic stability in yeast.
COMPLE X TR AITS
ABSTRACT Climate change has altered life history events in many plant
species; however, little is known about genetic variation underlying seasonal
thermal response. In this study, we simulated current and three future
warming climates and measured flowering time across a globally diverse set
of Arabidopsis thaliana accessions. We found that increased diurnal and
seasonal temperature (13) decreased flowering time in two fall cohorts.
The early fall cohort was unique in that both rapid cycling and overwintering
life history strategies were revealed; the proportion of rapid cycling plants
increased by 37% for each 1 temperature increase. We performed
genome-wide association studies (GWAS) to identify the underlying genetic
basis of thermal sensitivity. GWAS identified five main-effect quantitative
trait loci (QTL) controlling flowering time and another five QTL with thermal
sensitivity. Candidate genes include known flowering loci; a cochaperone that
interacts with heat-shock protein 90; and a flowering hormone, gibberellic
acid, a biosynthetic enzyme. The identified genetic architecture allowed
accurate prediction of flowering phenotypes (R2 > 0.95) that has application
for genomic selection of adaptive genotypes for future environments. This
work may serve as a reference for breeding and conservation genetic studies
under changing environments.
COMMENTARY
Dense Core Vesicle Release: Controlling the Where as Well as the When
Stephen Nurrish
Genetics March 2014 196:601-604
GENE E XPRESSION
GENE TICS OF SE X
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COMMENTARY
Variations on a Common STRUCTURE: New Algorithms for a Valuable Model
John Novembre
Genetics July 2014 197:809-811
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PERSPECTIVES
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NEW MOON The bristle worm Platynereis dumerilii has a long history as a
model for circalunar chronobiology and has proven an important reference
species for evolution and development studies. A pair of articles published in
2014 marks a new phase for the bristle worm as a tractable molecular genetic
model. Bannister et al. describe the first method for generating targeted genome
modifications in annelids, while Zantke and Bannister et al. review the wealth of
recently established Platynereis experimental tools. The artwork here represents
the transformation of the living fossil to a functional laboratory model.
Image courtesy of Florian Raible.
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PRIMERS
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After Acceptance
Within days, manuscripts are published Early Online, indexed in
PubMed, and available to colleagues. You may be selected for
highlights in GENETICS, cover art, press releases, promotion on
blogs, social media, and other outreach. We enhance discovery and
use of your research, which in turn increases its impact.
Community Support
Our journals are run by and for scientists under the aegis of the Genetics Society
of America. GSA represents us, advocates for us, convenes us, publicizes us,
provides educational resources, and fosters our work.
GENETICS and G3 have long been committed to integrating with community resources.
We recently partnered with Cold Spring Harbor Laboratories to enable seamless
deposits of manuscripts from GENETICS and G3 submission systems straight into
bioRxiv, and have for years supported arXiv deposits. Articles feature links to model
organism databases like SGD, FlyBase, and WormBase. In 2015, were providing
custom templates for authors who use LaTex, saving them time at submission.
Access to Data
Our data policy, instituted in 2009, requires that all primary data
and source code associated with the manuscripts findings must be
publicly available, either as supplemental information or in a public
repository like Dryad, FigShare, and GenBank. Besides providing
everything needed for replication, this policy allows your research to
have the greatest possible impact, and to ensure that your findings
will be used for years to come.