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Department of Dermatology,
Boo Ali Sina (Avicenna)
Hospital, 1Department of
Pharmaceutics, Faculty of
Pharmacy, Mazandaran
University of Medical Sciences,
Sari, Iran
Address for correspondence:
Dr. Zohreh Hajheydari,
Boo Ali Sina (Avicenna)
Hospital, Mazandaran
University of Medical
Sciences, Sari, Iran. E-mail:
zhajheydari@yahoo.com
ABSTRACT
Background: Finasteride, a type selective 5reductase inhibitor, as a causative agent of
decreasing dihydroxy testestrone (DHT) level, is effective in the treatment of male androgenic
alopecia. Aim: We compared the local and oral nasteride in the treatment of androgenic
alopecia. Method: This is a double blind, randomized clinical trial study of 45 male patients,
who were referred with alopecia to the private clinics and departments in Boo-Ali Sina Hospital,
in Sari. Patients with male androgenic alopecia were selected according to the history and
physical examinations. The patients were randomly divided into two: topical nasteride (A)
and oral nasteride (B) groups. Topical nasteride group (A) received a topical gel of 1%
nasteride and placebo tablets, while the oral nasteride group (B) received nasteride tablets
(1 mg) and gel base (without drug) as placebo for 6 months. The patients were followed
by clinical observation and recording of side effects prior to the treatment and at the end
of rst week, and then by a monthly follow-up. The size of bald area, total hair count, and
terminal hair were studied. Data were analyzed by descriptive and Chi-square statistical test.
Results: The mean duration of hair loss was 18.823.10 months. Each month the terminal
hair, size of bald area and hair count between the two groups were compared. There were
no signicant differences between the two groups as a viewpoint of hair thickness, hair
counts and the size of bald area. Serial measurements indicated a signicant increase in
hair counts and terminal hair counts between the two groups. Conclusions: The results of
this study showed that the therapeutic effects of both nasteride gel and nasteride tablet
were relatively similar to each other.
Key words: Androgenetic alopecia, nasteride, topical gel
INTRODUCTION
Loss of hair and alopecia are the most common
problems of modern societies, which create many
economical and psychological effects. Recently, a great
effort has been made to treat hair loss and alopecia, in
which some of them were successful. One of the most
common types of alopecia is baldness or androgenetic
alopecia. This kind of alopecia is recognized by
progressive narrowing of hair in the vertex and frontotemporal area of scalp, in persons with genetic potency.
The alopecia is hereditary in nature and is formed due
to the high testosterone receptors in scalps of involved
persons. Dihydroxy testosterone is an active form of
testosterone that is produced by enzyme type , 5-
reductase from testosterone.[1] Testosterone affects hair
follicle, resulting in hair shaft thinning, shortening of
How to cite this article: Hajheydari Z, Akbari J, Saeedi M, Shokoohi L. Comparing the therapeutic effects of nasteride gel and tablet in
treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol 2009;75:47-51.
Received: March, 2008. Accepted: May, 2008. Source of Support: Mazandaran University of Medical Sciences. Conflict of Interest:
None declared.
Indian J Dermatol Venereol Leprol | January-February 2009 | Vol 75 | Issue 1
47
Hajheydari et al.
Hajheydari et al.
RESULTS
DISCUSSION
Of the 45 androgenetic alopecia patients who were
enrolled, 7 were excluded from the study due to
incomplete or discontinuation of the entire study
period. The patients age range was 22.83.3 years. The
average time of hair loss in patients, were 23.10 18.8
months. Seven (18.4%) were married and 31(81.6%)
were single. Among referred patients, 31(81.6%) had
a positive family history of male alopecia and in
7(18.4%), it was negative. Nineteen patients entered
in group A, while 19 in group B randomly.
The average total hair count, terminal hair count and
the size of bald area in both groups in the beginning and
end of treatment respectively are shown in Table 1.
There were no significant statistical differences in the
terminal hairs, size of alopecia area and hair count
between two groups.
In A group (Finasteride gel and placebo tablet), increased
terminal hair count were observed at the third month
of treatment (P=0.001), but increased in terminal hair
count was shown in the second months in the B group
(Finasteride tablet and placebo gel) (P=0.015). During
therapeutic period, the size of alopecia area was not
significantly altered in group A, but in group B, the
change in size of alopecia area was significant in the
fourth month of treatment (P=0.027). Increased hair
Table 1: Mean of hair count, number of terminal hair and size of alopecia area before and after therapy in both A and B groups of
patients by androgenic alopecia
Hair counts
Number of terminal hair
Size of alopecia (cm)
Kind of treatment
Before therapy
After therapy
P - value in
each group
P - value between
2 group
gel
tablet
139.7434.21
147.833.91
0.0000
0.642
137.8935.33
153.5636.28
0.0000
gel
108.4237.6
113.2739.74
0.001
tablet
105.5839.33
118.6137.49
0.0000
gel
7.212.08
6.722.41
0.08
tablet
7.552.28
7.182.17
0.07
0.661
0.453
49
Hajheydari et al.
Mild
Count
%
Moderate
Count
%
Gel
12
34.2
17.1
Tablet
11
31.4
17.1
Gel
13
37.1
14.2
Tablet
10
28.5
20
Gel
12
34.2
17.1
Tablet
10
28.5
20
Gel
12
34.2
17.1
Tablet
10
28.5
20
Gel
12
36.3
18.1
Tablet
10
30.3
15.1
Gel
12
36.3
18.1
Tablet
10
30.3
15.1
P value
ACKNOWLEDGEMENT
1
0.4
0.7
0.7
REFERENCES
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Hajheydari et al.
15. Hamilton JB. Drug category. Available from: http://www.
emedicine.com/derm/topic21.htm. [cited on 2003].
16. Burkhart CG, Burkhart CN. 5 alpha reductase and finasteride
in pattern alopecia and acne. J Drug Dermatol 2004;3:363-4.
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