Company Profile for Globus Medical Inc

Globus Medical, Inc., incorporated on March 3, 2003, is a medical device company. The Company is
focused on developing products for patients with musculoskeletal disorders. It is focused on
products to treat patients with spine disorders. Its products consist of two categories: Innovative
Fusion and Disruptive Technologies. Innovative Fusion products comprise fusion products to treat
various spinal disorders for the entire spine and can be used in various surgical approaches.
Disruptive Technologies represents a shift in the treatment of spinal disorders by allowing for
surgical procedures and the treatment of spinal disorders.
Innovative Fusion
The Company's Innovative Fusion portfolio comprises treatment modalities from the occiput to the
sacrum. Its products address the spine to treat degenerative, deformity, tumor and trauma
conditions. The Company's pedicle screw platform, CREO, includes a non-threaded locking cap
design that eases building of thoracolumbar fixation constructs to adapt to the patient's anatomy
and condition, for a range of clinical applications. It also made additions to the CREO platform,
including streamlined instruments that offer surgeons options for any situation or preference.
Innovative Fusion products are used in cervical, thoracolumbar, sacral, and interbody/corpectomy
fusion procedures to treat degenerative, deformity, tumor and trauma conditions.
Disruptive Technologies
The Company's portfolio of approved and pipeline Disruptive Technology products includes products
that allow for minimally invasive surgical (MIS) techniques, as well as treatment alternatives,
including motion preservation technologies, such as dynamic stabilization, total disc replacement
and interspinous process spacer products, and biomaterials technologies, as well as interventional
pain management solutions, including treatments for vertebral compression fractures. Its MIS
products enable a surgeon to perform a procedure less invasively to minimize tissue disruption and
maximize native anatomy, which leads to better patient recovery and fewer approach-related
complications. Its products include CALIBER, RISE and LATIS interbody spacers, which are
designed to enable minimally disruptive delivery through small MIS incisions with streamlined
implants and instruments. Its various fixation options, including plates and pedicle screw systems
designed for minimally invasive insertion. Its other Disruptive Technology products include its
motion preservation offerings, such as SECURE-C and SECURE-CR, which are cervical arthroplasty
devices that allow segmental motion, are semi-constrained, and provide alternatives to fusion in the
treatment of degenerative conditions. Its product, MONUMENT, is an interbody implant for the
reduction of a grade 1 spondylolisthesis using its built-in, self-locking mechanical reduction feature.
The Company's biomaterials products include bioactive glass-based KINEX and SIGNIFY bone void
fillers and CONDUCT ceramic-collagen, which are suitable for pelvic/extremity and posterolateral
spinal fusion procedures. Its SHIELD and AFFIRM products allow for the treatment of painful
vertebral compression fractures.

The Company received Food and Drug Administration (FDA) pre-market approval for its SECURE-C
Cervical Artificial Disc and is conducting other clinical trials under FDA-approved investigational
device exemptions (IDEs), including ACADIA and TRIUMPH. The ACADIA Facet Replacement
System is a motion preserving anatomic reconstruction of the facet joint for the treatment of spinal
stenosis. A pivotal study of ACADIA is being conducted in the United States to enroll and treat up to
750 qualified patients randomly selected for the treatment or control of posterolateral fusion arm in
a 2:1 ratio. The TRIUMPH Lumbar Disc is a motion preserving disc replacement inserted obliquely
into the disc space from a posterolateral approach to address posterior spinal pathology and
maintain important anterior anatomical structures. A 20-patient IDE pilot study for treatment of
patients suffering from back and leg pain has been completed. Both ACADIA and TRIUMPH are
European Conformity marked (CE marked) and available for sale in certain jurisdictions outside the
United States.
The Company competes with Medtronic, Johnson & Johnson, Stryker, NuVasive, Alphatec Spine,
Orthofix International, Zimmer, LDR Holding, Biomet and K2M.