infection, particularly in patients with persistent organ failure or a systemic inflammatory response. 4
Jaundice?
Organise an urgent abdominal USS for all
patients with acute upper abdominal pain and jaundice to look for evidence of biliary obstruction or hepatitis. Assume biliary sepsis, at least initially, if the patient is unwell with high fever rigors or cholestatic jaundice (p. 177); give IV antibiotics and, if the USS confirms a dilated CBD, refer immediately to surgery for biliary decompression. Assess as described in Chapter 19 if there are clinical or USS features of acute hepatitis. 5
Inflammatory response?
At this stage, use the presence or absence of
a systemic inflammatory response (see Box 4.1) to narrow the differential diagnosis. Arrange prompt abdominal USS to confirm or exclude acute cholecystitis in any patient with inflammatory features accompanied by any of the following: localised RUQ pain direct tenderness to palpation in the RUQ positive Murphys sign (sudden arrest of inspiration while taking a deep breath during palpation of the gallbladder). In the absence of acute cholecystitis, the USS may reveal an alternative cause for the presentation, e.g. pyelonephritis, hepatitis, subphrenic collection. If none of these features is present, consider alternative disorders: basal pneumonia if there is clinical or CXR evidence of basal consolidation (see Figs 12.3 and 12.4, pp. 116 and 117), especially if accompanied by productive cough or dyspnoea gastroenteritis in patients with an acute vomiting illness and no abdominal guarding or rigidity (reassess regularly) 36
acute pyelonephritis if urinalysis is
positive for leucocytes/nitrites. Otherwise, consider USS/CT to exclude atypical presentations of acute appendicitis/ pancreatitis/cholecystitis, Crohns disease or other acute inflammatory pathology. 6
Characteristics of biliary colic?
Biliary colic is a common cause of acute
severe upper abdominal pain in patients who are otherwise well and do not exhi bit evidence of a systemic inflammatory response. Abdominal USS can assist the diagnosis by demonstrating the presence of gallstones. However, asymptomatic gallstones are very common and so the history is critical to making an accurate diagnosis. Look for the following suggestive features: onset of pain a few hours after a meal (may waken the patient from sleep) duration 6 hours followed by complete resolution of symptoms the main site is the epigastrium or RUQ radiation to the back constant, vague, aching or cramping discomfort (it is not, strictly speaking, colicky) history of previous similar episodes. Arrange abdominal USS only in patients with a suggestive history. If the pain has settled and LFTs are not deranged, USS may be performed in the outpatient department. 7
Consider other causes observation/
surgical review if any concern
Systemically well patients with an acute
vomiting illness and recent infectious contact or ingestion of suspicious foodstuffs are likely to have gastroenteritis. Suspect acute gastritis if the patient reports new-onset gnawing, burning or vague epigastric discomfort mild tenderness especially if this is associated with dyspeptic symptoms e.g. nausea, belching, heartburn, or a history of recent alcohol excess/NSAID use; consider peptic ulcer