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Use of Peptide Therapeutics in Treatment of Diverse Medical Conditions Stimulates Market Growth
Use of Peptide Therapeutics in Treatment of Diverse Medical Conditions Stimulates Market Growth
Use of Peptide
Therapeutics in Treatment
of Diverse Medical
Conditions Stimulates
Market Growth
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Therapeutic peptides have received acceptance in the treatment of several diseases such as
metabolic disorders, cancer, nervous system disorders, gastrointestinal disorders,
acromegaly, hematological disorders, cardiovascular disorders, infections, and respiratory
disorders, among others. Due to the efficacy of peptides for the treatment of a large number
of medical conditions, further research and development has resulted in a rich pipeline of
novel peptides that deliver better therapeutic effects.
Though animal sources such as venom constitute the major source for peptide research,
microbial sources are also being examined for their efficacy for treatment of various medical
conditions. The growing variety of sources as well as applications of peptide therapeutics is
boosting growth prospects of the global peptide therapeutics market. However, despite
extensive research, oral administering of therapeutic peptides still remains a challenge for
researchers, which is indirectly hampering the peptide therapeutics market. Unfavorable
physiological conditions such as the presence of proteolytic enzymes and acidic pH pose a
challenge for oral administering of peptide therapeutics. Moreover, low intestinal penetrability
of peptides also adds to the low bioavailability of these substances.
Lately, a strong trend has been observed in the peptide therapeutics market: whilst new
peptide therapeutic drugs receive regulatory permission, several older peptide therapeutic
drugs will go off-patent during the forecast period. In addition, difficulties associated with
imitating the precise effects of biologics are a major reason for generic drug manufacturers
to face drug approval issues. Thus, generic peptide therapeutic drugs are priced only 70-80%
as much as branded peptide therapeutics. Due to this price gap, high demand for generic
versions is expected to help the peptide therapeutics market overcome its restraints.
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Presently, the generic peptide therapeutic leuprolide is retailed under the brand names
Eligard, Lupron, and Enantone, of which Lupron and Enantone constitute sales over US$800
mn across the world.On the competitive front, currently, Teva Pharmaceutical Industries Ltd.,
Novo Nordisk, and Takeda Pharmaceutical Co. Ltd. collectively account for more than 50% of
the global peptide therapeutics market. However, the patent expiration of Copaxone in 2014
and Velcade in 2017 will lead to launch of their generic alternatives. Some other prominent
players in the global peptide therapeutics market are AstraZeneca plc, Eli Lilly & Co., Merck
& Co., Novartis International, and AbbVie Inc.
The global peptide therapeutics market has been segmented as below:
Global Peptide Therapeutics Market, by Application
o Cancer
Zoladex (goserelin)
Velcade (bortezomib)
Lupron/ Enantone/ Eligard (leuprorelin)
Others
o Cardiovascular
Angiomax (bivalirudin)
Integrilin (eptifibatide)