Home

About Us

Calendar

Consults

Learn
o Suggested Readings

Photos
o Fellows Graduation 2013

Suggested Readings

Documents

Schedule

Patients
o On-going Trials at Tulane
o Patient Info

Checkout

Nephrology Practice Board Question FSGS Answers

August 26, 2014 Board Review, FSGS, Glomerulonephritis

As Ive been studying Ive been trying to make up questions of information that I found to be
important or interesting (at least to me). These questions and those to follow are a random
grouping of multiple choice, true/false, or guess what Im thinking.
1.) Collapsing FSGS is associated with what disease/drugs?
1.) HIV
2.) Parvovirus B19 infection
3.) Interferon therapy
4.) Pamidronate toxicity
2.) Which monosaccharide sugar has been shown to normalize the permeability factor in FSGS?
A. Fructose
B. Sucrose
C. Galactose
D. Glucose
It has a high affinity for the cardiotrophin-like cytokine 1 permeability factor (aka the FSGS
PF or FSPF). I has be shown to improve the permeability factor in several patient with
refractory FSGS in (case studies).
3.) Secondary forms of FSGS occur via what mechanism?
They are mediated by adaptive structural-functional responses due to reduction in te number
of functioning nephrons (wheter acquired or congenital). There is increased hemodynamic
stress on the remaining nephrons and lead to glomerular hypertrophy and perihilar lesions of
segmental sclerosis and hyalinosis.
4.) In children with FSGS as the cause of ESRD a transplant from a living related donor gave a
better allograft survival than from a cadaveric donor.
True, especially in African American children with FSGS where there is no difference in long
term allograft survival vs non-FSGS allograft recipents.
5.) Mutations to APOL1 are protective against what infectious parasite?
A. Plasmodium falciparum
B. Trypanosoma brucei
C. Giardia lamdia
D. Toxoplasma gondii
6.) Pseudocrescents (hyperplastic visceral epithelial cells swollen and crowded together) are
associated with which variant of FSGS?
A. Collpasing
B. Perihilar

C. Tip
D. Cellular
7.) Secondary forms of FSGS associated with hyperfiltration such as remnant kidney and
obesity-related glomerulopathy typically have lower levels of proteinuria. True/False?
TRUE
8.) The structure in the picture is associated with which diseases?

Interferon therapy, HIV, and Lupus. This is a picture of a tubuloreticular body.

9.) What IF pattern is often seen in FSGS?

A. IgM
B. IgA
C. C3
D. C4d
E. A and C

F. A and B
G. B and D
10.) What is the first-line treatment of FSGS in patients with nephrotic syndrome?
A. Pulse methylprednisolone for 3 days
B. Prednisone 1mg/kg/day for 6-8 weeks with subsequent tapering
C. Cyclophosphamide 0.5mg/m2/day IV for 3 months
D. No immunosuppression just conservative therapy
11.) What medications/drugs are associated with secondary FSGS?
Heroin
Lithium
Pamidronate
Sirolimus
Interferon (alpha,beta, or gamma)
12.) What risk factors are best prognosticators for progression to ESRD in FSGS at biopsy?
A. Reduced GFR
B. Greater degree of proteinuria
C. Greater degree of intersitial fibrosis.
D. All of the above
-Adrian

Search

Recent Posts
o Potassium and Blood Pressure
o Acid Base Practice Questionsand Answers
o Theres A New Binder On the Block: FDA Approves Patiromer
o Quick & Dirty Dialysis How-To For New Fellows
o Monoclonal Gammopathy of Renal Significance (MGRS)

Categories
o Acid/Base

o AKI
o Anemia
o Board Review
o CKD
o Contrast Induced Nephropathy
o Critical Care
o Dialysis
o Differential Diagnosis
o Electrolytes
o ESRD
o FSGS
o Glomerulonephritis
o Hematuria
o Hepatorenal Syndrome
o HIV
o Hypertension
o Membraneous
o Metabolic Acidosis
o Nephrotic Syndrome
o Nutrition
o Pathophysiology
o Physiology

o Potassium
o Proteinuria
o Renal Tubular Acidosis
o Secondary Hyperparathyroidism
o Sodium
o Transplant
o Uncategorized

Archives
o December 2015
o October 2015
o July 2015
o June 2015
o May 2015
o April 2015
o February 2015
o November 2014
o October 2014
o August 2014
o July 2014
o June 2014
o April 2014
o March 2014

o February 2014
o December 2013
o November 2013
o October 2013
o September 2013
o August 2013
o July 2013
o May 2013
2016 Redbeans
Powered by WordPress | Designed by: Free WordPress Themes that Recommend Web Hosting
Reviews

Nice job!
You now have 30 beans.
Use them wisely, my friend.
Konami Easter Egg by Adrian3.com