Professional Documents
Culture Documents
Catalysis. Active site geometry. Stabilization of transition states. The catalytic mechanism of
proteases. Enzyme engineering. (Oct. 29)
11. The role of molecular structure in genetic regulation. (ch. 7)
Molecular biology into systems biology. The molecular switch in the lambda phage:
explanation in terms of molecular structure, binding, and cooperativity. Protein-DNA
interactions (ch.6-8) (Nov. 3)
EXAM II (November 5)
12. The role of molecular structure in metabolism and metabolic regulation. (handouts)
Metabolic pathways. Methods for studying metabolism and its regulation. Flux balance
analysis. Regulation by covalent modification. The Goldberger-Koshland model of a
molecular switch. (Nov. 10)
13. Signal transduction. (handouts)
Classification and examples of signal transduction pathways. Specificity, amplification,
and signal integration. (Nov. 12)
14. Methods for determining structures (ch. 17)
X-ray crystallography (basic concepts only); NMR analyses (basic concepts only)
Computational methods in structure determination. Refinement tools. Review. (Nov 17)
15. Docking and drug design. (handout) (Nov 19 & 24)
EXAM III: December 1
16. Student presentations (Dec. 3, 8, 10)