Pathophysiology

Precipitating Factors:
Aedes Aegypti
Mosquito
Environment (open
spaces with water)

Platelet will provide a shield

for the virus from exposure
and binding to neutralize
pre-existing antibody

Macrophages or monocytes
engulfed the virus having the
platelet (phagocytosis)

Vasculopathy
(Plasma
leakage)

Mosquito injects fluid into patients

skin
Virus enters into the hosts blood
stream
Infects cells and replicate in sufficient
amount
Initiates an immune response
Activation of memory T-cell response
during re-exposure
Virus- anti body complex
(Binding of ab-virus)

AB- enhance uptake

Coagulopathy
(PT/APTT)

Virus ultimately targets liver and

spleen parenchymal cells where
infection produces apoptosis/cell
death

Hepatosplenomegaly

Predisposing Factors:
Age, Heredity, Sex, Age

Bite of a virus carrying

mosquito

Cytolysis
Cellular direct destruction and
infection of red bone marrow
precursor cells as well as
immunological shortened platelet
survival causing platelet lyses

Thrombocytopenia

Dengue Hemorrhagic
Fever

Stimulates release
of cytokines

High fever, body

weakness,
headache and
dizziness
Cytokines destroy cell
membrane and cell wall (viral
antigens found in monocytes)

Complement system activation

Vascular endothelial activation