I h-e TNS. Monarch eINS System vamonarcheTNS.com by NeuroSigma _ Monarch by NeuroSigma The NeuroSigma Monarch™ eTNS™ System is @ non-invasive medical device that stimulates the trigeminal nerve via an external conductive patch. Its @ safe and effective treatment for depression that can be x performed at home daily, primarily while asleep. Its now available in the ) European Union and Canada with a physician's prescription with eTNS™ Depression is a common and disabling medical condition. Many individuals continue to suffer from severe depression despite trying multiple anti- depressant medications, often in combination. Few effective options are available to people whose depression is resistant to drug therapies. Cranial nerve stimulation has been used to treat depression for more than a decade, but the Monarch™ eTNS System Is the first safe and effective system that does not require surgery. 52% Symptom Reduction in Major Depression* 3 NeuroSigma The eTNS system was developed and tested by doctors at the University of California, Los Angeles (UCLA). The eTNS system offers an especialy attractive option because it does not require surgery and has been shown tobe successful at treating patients with medication resistant depression. Treatmantjof depression with EN Sse Seu kecaneucns Patients use the system in the comfort of their ee te eee Ree ee oe et ee ae Se eon eee 2 tingling sensation and most choose to deliver the therapy at night while they sie‘The concept of brain stimulation to trest depression is well-known. Your physician, however, might net know about the Monarch eTNS system as a treatment option. ‘Since you will need a doctors prescription to obtain the Monarch System, NeuroSigma has developed this brochure designed to help you start a ‘conversation with your physician about the therapy. What does eTNS mean? tran aberavition for extomalTagamina Nowe ‘Stinuition What is the Monarch eTNS System? The Mansion ssiom i 8 nonsmsasbe erapy {approved nthe European Union and Canada for tho gure reatent of eplepsy and depression n patents ages 9 and ler How does it work? A smal elect patch i pied the forhond just above the eyebrows. Lead wes connect the patches to. handia device that can be fastened oa beh caries na pocket. or paced beste your bed. Mitt ccc cents then simul te geminal nae Patents ypcaly par atngingsersston that as ot interfere with day actus or sleep When does the treatment occur? tohhave the stimulation therapy occur whi hey seep. Your D octor IG Who are good candidates? Patonts may ty the Monarch they have boon aograced th opiozsy or dopressn ode ‘ymoms ar et sucess managed wth Imescater Typealy, patents ave ted teas! wo drag therapies beer consider eT. Where was the treatment developed? TNS was iwonted by foam of octors ad researchers a the Univers of Calfomia, Los Angeles UCLA) UCLA physicians wore vated n some ofthe gia sucoe of vagus nerve stimulation (YN) fine troatmert of eptepsy, ana bogan e develop OTS asa ovate aerate fo UNS eT hae now been usec How much does the Monarch eTNS System cost? The Monarch #TNS System canbe purchased brecty tram NeweSigna. The sath €800 ($1100) andincvdes eventing a patont noose for decode clinica stuces af UCLA. NouroSgma is smatng this teatent aval options ought the wopean Union ant Canad to begin nrapy anda +-weok supply oF lec patches. Acional patos can Be purchased from Neuro Sigma tor €10 (C319) each Althis tine the Monarch not covered by surance, Where can | read peer-reviewed papers that have been published in scientific journals? How do you obtain it? A pation mus have 9 physcians presction to-acqie he Monarch e7NS sytem. Psst NeuraSioma's pubations page tp monarch-oTNS.comiphysicians/publcatons For P ans ‘The Monarch eTNS System isan innovative medical device from NeuroSigma, which provides non-invasive electrical simulation tothe V1 branch ofthe trigeminal nerve “The tigemina nerve (also known as the th cranial nerve or Cranial NewveV)is the largest rail nee and provides wensaton i he face via hres min branches (V1, 2, and Va), Duet its unique anatomy, the tigeminal nerve i effectively stimulated vith noninvasive electrical signals applied to the forenead YSIC (015 Positron Emission Tomography (PET) stucies of patients receiving eTNS have demonstrated acute changes in cerebral blood flow and metabolism. These studies show decreased blood flow in regions of the cortex known to be involved in the initiation and propagation of seizures, while simultaneously showing increased blood flow in brain regions shown to be hypometabolic in depression,