GENERIC

NAME

BRAND
NAME

ACTION

Residents Name: Mio Franco S. Quilit

Quetiapine Ketilept Description: Quetiapin
fumarate
e is an
dibenzothiazepine
atypical antipsychotic
agent. Its clinical
antipsychotic
properties and low
extrapyramidal side
effect is mediated
through a combination
of D2and 5HT2 receptor
antagonism. It has
high affinity at
histaminergic H1 and
adrenergic
1 receptors,
moderate affinity at
adrenergic
2 receptors and
moderate to high
affinity at several
antimuscarinic
receptors.
Pharmacokinetics:
Absorption: Well
absorbed. Time to
peak plasma
concentration: Approx
1.5 hr.
Distribution: Widely
distributed throughout
the body. Volume of
distribution: 6-14 L/kg.
Plasma protein
binding: Approx 83%.

INDICATION &
DOSAGE
Treatment of
schizophrenia
DRUG
& also for the
treatment of
moderate to
severe manic
episodes
associated w/
bipolar
disorder.

CONTRAINDICA
TION

Cytochrome P450 3A4

STUDY
inhibitors eg
HIV protease
inhibitors,
azole
antifungal
agents,
erythromycin,
clarithromycin
& nefazodone,
Schizophrenia phenytoin,
1st 4 days: 50 carbamazepine
mg (day 1);
, barbiturates,
100 mg (day
rifampicin,
2); 200 mg
glucocorticoids
(day 3); 300
, cimetidine,
mg (day 4).
thioridazine,
May adjust to
lorazepam,
150-750 mg
alcohol.
daily. Manic
episode
Special
associated w/
Precaution:
bipolar
disorder 1st 4
Known CV
days: 100 mg
disease,
(day 1); 200
cerebrovascula
mg (day 2);
r disease,
300 mg (day
other
3); 400 mg
conditions
(day 4). May
predisposing to
adjust up to
hypotension.
800 mg/day by Patients w/
day 6 in
congenital long
increments not QT syndrome,
>200
CHF, heart

ADVERSE
REACTION
Somnolence,
headache,
dizziness, wt
gain, rises in
plasmatriglyceride and
total cholesterol
concentrations;
mild asthenia,
anxiety,
irritability, fever,
rhinitis,
peripheral
oedema,
increased
appetite,
constipation,
dyspepsia, dry
mouth, raised
liver enzyme
values;
orthostatic
hypotension
associated w/
dizziness,
tachycardia, and
syncope;
leucopenia,
neutropenia,
thrombocytopen
ia, eosinophilia,
reduced Hb and
plasma-thyroid
hormone
concentrations;
asymptomatic

NURSING
RESPONSIBILITY
ETD: August 10, 2015
An effective
nurse should
first identify and
practice the
rights of
patients such
as: right
patient, right
drug, right
dosage, right
route and right
time ,
administration
and
documentation
In cases any
adverse drug
reaction and
side effect
either good or
bad caused by
medication
error, allergy
and/or toxicity
on any
unspecific drug.
One nurse
should easily
identify the
cause and
effect it may
bring and
immediately
refer it to the
attending