vWF and collagen being exposed

SEC - platelet attachment - GPIb - vWF

Adherence to vWF is first step
intracellular signals > to promote further aggression
Home plate ready to degranulate >
ADP is secreted by platelets (induces aggregation)
5-HT is also secreted by platelets (Simely face getting thrown by
local aggregator and vasoconstrictor
TXA2 (batter box near home plate)
TXA2 is synthesized inside platelets by COX
COX2 is preferentially expressed @ sites of inflammation
Sleeping coach 2 is inactivate (sleeping)
COX1 synthesizes TXA2 from Arachidonic acid (precursor)
TXA2 is a potent vasoconstrictor
Aspirin (ASA: Empire antagonizing) inhibits the synthesis of
TXA2
COX1 and COX2 are irreversibly inhibited by aspirin
Blocking platelet surface receptors
Inhibit ADP pathway of platets
HOT DOG GRILL: thienopyridines with -grell suffix (e.g.
clopidogrel, ticagrelor, prasugrel) are ADP receptor
inhibitors
If aspirin not tolerated given them
Anti platelet agent used to reduced cardiovascular events in
patient with coronary artery disease
rescue risk of vascular events
clopidogrel
Dual antiplatelt therapy takes advantage of both pathways
reducing platelet aggregation (aspirin and p2y12 ATP receptor
inhibitor )
acute MI the broken heart strings of a heart-shaped banjo
platelet adhesion
the first tablet should be chewed or crushed to establish a high
blood level quickly
coronary artery stent - court bat
black stroke of paint on the painters cap is our recurring
sketchy symbol for ischemic stroke
clopidogrel is often used and can be combined with aspirin as
well as other antiplatelet

Corked bat - dual antiplatelt therapy (aspirin and ADP receptor

inhibitors prevent coronary stent thrombosis
ticolpidine (ADP receptor inhbitor)
geanulocytopenia
IIB/IIIA receptor binds to fibrongien and promote lately
aggregation
ABC