1. You have a patient who is experiencing progressive difficulty with swallowing liquids and solid food.

Subsequently, the patient undergoes a barium swallow that reveals stenosis of the lower esophageal
sphincter. What is the diagnosis associated with this barium swallow finding? What are some
common causes of this diagnosis? (FA13 p324) (FA14 p349)

2. In the lower extremity, what are some of the clinical differences between peripheral vascular disease
(PVD, also known as peripheral artery disease (PAD)) and deep venous thrombosis (DVT)? (H p2066,
2170)

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3. A 22-year-old man suffers a stabbing injury to the chest. He has lost a lot of blood, and you are
concerned that his cardiac output is low. What are the two equations for cardiac output? (FA13 p253)
(FA14 p266) (SU14 p70)

4. A 66-year-old man currently taking warfarin for atrial fibrillation is instructed to avoid food products
that contain vitamin K to optimize anticoagulation. For what coagulation factors is vitamin K
necessary? (FA13 p95) (FA14 p96) (SU14 p272)

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5. Your 46-year-old male patient is asking your advice on whether to take a daily aspirin. How does
taking an aspirin a day prevent platelet aggregation and myocardial infarction? Which two arachidonic
acid products affect platelet aggregation? (FA13 p404) (FA14 p439) (SU14 p245-246, 274)

6. A 5-year-old boy is treated with mebendazole for a pinworm infection. Mebendazole acts on
microtubules to inhibit the pinworms. What other medications act on microtubules? What syndrome
demonstrates a defect in microtubule polymerization? (FA13 p76, 207) (FA14 p78, 213)

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7. Thiazolidinediones (TZDs) increase expression of one type of GLUT receptorsthose in adipose

tissueas one of their antidiabetic actions. Which GLUT receptors would you expect to find on skeletal
muscle and fat? (FA13 p288) (FA14 p308) (SU14 p311)

8. What is compartment syndrome, and how is it treated? (SU14 p244) (COA p540)

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9. An 18-year-old woman has seasonal allergies. She complains that her eyes water and her nose runs
constantly during the spring. Which cell type is responsible for her symptoms, and what drug inhibits
these cells action? What WBCs descend from the myeloblast (granulocyte) lineage? (FA13 p345-346)
(FA14 p374-375) (SU14 p257, 266)

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10. Which GI ligaments match the following descriptions? (FA13 p310) (FA14 p336)
Description

GI ligament

Separates the greater and lesser sacs

May be cut during surgery to access the

lesser sac

2 ligaments that connect the spleen to

other structures

Contains the portal triad

Connects liver to the anterior abdominal

wall

*Page references are as follows:

FA13: First Aid for the USMLE Step 1 2013
FA14: First Aid for the USMLE Step 1 2014
SU14: Step-Up to USMLE Step 1 2014
R: Robbins and Cotran Pathologic Basis of Disease, 8th ed. (2010)
Phys: Guyton and Hall Textbook of Medical Physiology, 12th ed. (2011)
H: Harrisons Principles of Internal Medicine, 18th ed. (2012)
COA: Clinically Oriented Anatomy, 6th ed. (2010)
GG: Goodman and Gilman Pharmacological Basis of Therapeutics, 12th ed. (2011)

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