Nama : Fenny Yuniharto

Sofia Rusdeni

201110410311118
201310410311073
Anti Histamin Generasi 1

N
o

Nama
Obat

1. Difenhidra
min

2. Clemastine

Onset
Efek
Maksim
um
sedative
: 1-3
jam
5-7 jam

Dur
asi

T
1/2

4-7
jam

2-10
jam ;
geria
tri :
13.5
jam
21.5
jam

10 12
jam

Farmakokinetika
Ikata
n
Adsor
BA
Prote
bsi
in
Ora 78%
72%
l:
40
%70
%
39. 95%
98%
2%

Meta
bolis
me

Eksk
resi

Hati

Urin

3-22
L/kg

Hati

Urin

800

urin

Vd

Lip
ofi
litas

Sed
ia
an

Log
p=
3,72

291, 82 Log 8.9

Xp
8
=
3.3

HC
L:
16

HC
L:
34

Log
p=
5,2

343.89
024

3.65

469.97

Log
p=
2,5

388.46

1530menit

3-6
jam

14
jam

98 99%

99%

hati

4.

Doxylamin

7.5 jam

10
jam

0,5
jam

96%

98%

hati

5.

Hydroxyzin
e

Oral:
15-30
menit

4-6
jam

3-7
jam

93%

Oral:
Rapid

Hati

Urin

Log
p=
2,7

6.

Promethazi
ne

Oral,
Rectal,
IM :20
menit
IV : 3-5
menit

2-3
jam

9-12
jam
(IV)
9,8
jam
(IM)

Hati

Urin

Log
p=
4.81

93%
(GC)
80%
(HPL
C)

pH
Zat
Ak
tif

Dimenhidri
nat

2,5L/
kg

Ko
ef.
Par
tisi

P
Ka

3.

urin

Uk.
Mole
kul

Log 9.5
Xp
5
=5
6.8

7.3

Log 5.8
Xp
=
2.5
763, 29 Log 2.4
Xp
7
=
3.7
Log
Xp
=
4.8

4.05.5

Struktur
Penting

Kati
on /
Anio
n

Bentuk
Molekul

C17H21NO

C21H26ClN
O

C24H28ClN
5O3

C17H22N2
O

C21H27ClN
2O2

C17H20N2S

7.

ciproheptadi
n

8. Chlorpenira
mine

9.

tripolidin

1
0.

Pheniramin
e

1
1.

Cyclizine

1
2.

Pyrilamine

46jam

6 jam

96%

Komp
lit

hati

50%di
urin
25%
faces

72%

usus

Hati
(cyp2
d6)

urin

Hati

urin

24
jam

6
jam

4-6
jam

3
3.3
jam

Rap
id 4
8
jam

20
jam

46
jam

90%

99%

350.89

Log 9.3
Xp
=
4.7

4.5

7.5

C21H21N

Log
p=
3.38

390.87

Log 9.2
Xp
=
3.4

3.3

3.5

C16H19ClN

Log
p=
3.92

278.39

Log 8.6
Xp
4
=
3.9

C19H22N2

Log
p=
2.85

240.34
34

Log 9.4
Xp
8
=
2.8

C16H20N2

Hati

Hati

Urin

Log
p=
3

266.38
068

Log 8.5
Xp
1
=
3.6

Hati

Urin

Log
p=
3.27

285.38
402

Log 8.8
Xp
5
=
3.3

Sumber Pustaka :
1. AHFS Drug Information 2008
2. AHFS Drug Information Essential 2011
3. Pubchem

Urin

4-7
L/kg

Log
p=
4.69

7.6
8.6

C18H22N2

C17H23N3
O

4. Drugbank (www.drugbank.ca)
5. Essential Drug Data for Rational Therapy in Veterinary Practice Oleh Kingsley Eghianruwa