e-mail: cdalla@med.uoa.

gr



.
&
.
. E
.

.


(, ,
)


v 1%
( )
v, ,
, ,

v

v

v1/3

30-120 sec- -

Status epilepticus: >30 min

-
(grand mal):
,
:

(petit mal):
, 10-45
sec




(Na+, K+, Ca2+)
(GABA - Glu)



(EPSP)

(IPSP)
EPSP
Na+
Ca++

IPSP
+
Cl-

GLU

GABA

Status epilepticus

1960

( )
( ) 1910
Status epilepticus

GABA


, ( t1/2 : 20 min),
( t1/2 : 1-2 )

()
: , , ,

: ( ).
().
.
, , ,
,


GABA
GABA


Na+, Ca 2+ , K

: per os,

/ 2

( )

450, (CYP 3A4)
( )


-

,
, (50%)

(6%)


: per os,

,

450,
(, )


-
:
, , , ,
i.v.
Stevens-Johnson

:
:
:
,

( D)


Ca2+

, ,

GABA
, ,

 (500-1500 mg/day)
, & , i.v.
,
,
(50-100 g/ml),
(),

,
,
, ,

(, )
: (,
)


GABA

GABA

-
Ca2+

()

v
(
/
):

.
v
(
/
).
.

Escalation Regimen for Lamotrigine for Patients

With Bipolar Disorder

For Patients
TAKING
Valproatea

For Patients
NOT TAKING
Carbamazepine,
Phenytoin,
Phenobarbital,
Primidone,b or
Valproatea

For Patients
TAKING
Carbamazepine,
Phenytoin,
Phenobarbital,
or Primidoneb
and NOT
TAKING
Valproatea

Weeks 1 and 2

25 mg every
other day

25 mg daily

50 mg daily

Weeks 3 and 4

25 mg daily

50 mg daily

100 mg daily, in
divided doses

Week 5

50 mg daily

100 mg daily

200 mg daily, in
divided doses

Week 6

100 mg daily

200 mg daily

300 mg daily, in
divided doses

Week 7

100 mg daily

200 mg daily

up to 400 mg
daily, in divided
doses

http://www.rxlist.com/script/main/hp.asp