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MKH 21 2 15 PDF
MKH 21 2 15 PDF
Uji Aktivitas Penurun Kadar Glukosa Darah Ekstrak Daun Eugenia polyantha
pada Mencit yang Diinduksi Aloksan
Test Pharmacological Effect of Ethanolic Extract of Eugenia polyantha Leaves as for Decreasing
Glucose Level Activity on Mice Induced by Alloxan
Herra Studiawan dan Mulja Hadi Santosa
Bagian Ilmu Bahan Alam, Fakultas Farmasi , Universitas Airlangga Surabaya
Abstract
The aim of this study was to know the pharmacological effect of salam leaves on mice which
would be focused on the effect in decreasing blood glucose level on mice induced alloxan.
Material use in this research was ethanolic extract of leaves of Eugenia polyantha. Two kg of
powdered dried leaves of Eugenia polyantha was macerated with ethanol. The ethanolic extract
obtained was used to decreasing glucose level activity using alloxan induced mice. Fourty five male
mice were divided into 3 group i.e group I, II, and control. Alloxan was given every 4 days at the dose
of 100 mg mg/kg BW i.p. The ethanolic extract then given orally for 7 consecutive days in the dose
2,62 mg (group I) and 5,24 mg/20 g BW (group II) from the 9 th day to 15 th day. Decrease of glucose
levels were calculated from the 8 th day to 15 th day. The data were analyzed by ANOVA and LSD tests
to compare groups I, II, a nd control. Based on the data analysis, there were a significance differences
(p = 0,05) between group I and control, group II and control. But, there was no significance difference
between group I and group II.
The result of this study showed that ethanol ic extract of Eugenia polyantha leaves decreased
glucose level of alloxan mice at the dose 2,62 mg/20 g BW and 5,24 mg/20 g BW.
Keywords: Eugenia polyantha, mice, alloxan, glucose level
Pendahuluan
62
Metode Penelitian
63
Herra Studiawan dan Mulja Hadi Santosa ; Uji Aktivitas Penurun K adar Glukosa Darah Ekstrak Daun
Kontrol
146,87
154,80
199,13
212,67
Kel. I
147,73
155,40
205,13
178,53
Kel. II
145,33
150,67
209,67
175,47
Jumlah Derajad
kuadrat bebas
Kuadrat
rerata
Antar
20923,911
kelompok
10461,956
Dalam
10325,733
kelompok
42
245,851
Total
31429,644
F
Probahitung bilitas
42,554
0.000
44
64
Kesimpulan
Pada kesempatan ini, kami ingin menyam paikan terima kasih yang sebesar -besarnya kepada
Ketua Lembaga Penelitian Universitas Airlangga atas
kebijaksanaannya sehingga penelitian ini dapat
didanai.
Daftar Pustaka
Agoes A., 1991, Pengobatan Tradisional di Indonesia,
Medika No. 8, Thn 17, hal.632
Brachmacari, H.D., K.T. Augusti, 1962, Effect of Oral
Effectivity Hypoglycaemic Agent, Journal of
Pharm. Pharmacol., vol 14, hal. 167
65