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- . .
() (). 1951.
, Howard Pelc
: GAP1, syntetic phase, GAP2 mitosis (G1, S, G2 ).
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, S , .
aa G1
G2 ( . Gap 1 Gap 2). G1

S-.
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(G0 )
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G1 .
G1 , .
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G0 .
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(1, 2, 3), , . - - CDK ( .
cyklin dependent kinasa), . -
,
(cyclin = cycl =
= ). CDK . -CDK, .
CDK. (. Myc)
CDK .
()
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, S
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: S ( G1 ), S
(- S ), ( G2
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( ) ATM ATR
( 1). G1 G2
p53.

p53 Cip/Kip p21.

cdk2, cdk4 cdk6,


G1 . G2
p53. , chk1 chk2
( ).
1 (cdk1). , , G2
-cdk
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chk1 chk2 cdk2.
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(cdk ).

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: housekeeping ()
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housekeeping .
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10.000 15.000 housekeeping , 1000
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housekeeping .
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DNA
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