1.

HbS

2.

hepcidin transferrin
microcytic hypochromatic ()
Pallor ()dizzinessdyspnea()fatigue
tachycardia()CO vasodilation

3.

1.Hemachromatosis
2. transfusion

10

4. B12

extrinsic factor
(pernicious anemia) intrinsic factor B12
macrocytic megaloblastic ()

Schilling test, B12

5.

megaloblastic ()
B12

1.EPO

34-39kDa glycoprotein,
EPOR JAK/STAT (reticulocytes)

1.hemocrit hemoglobin EPO

2. EPO, exogenous EPO
target population
: 1.hemoglobin 10-12g/dL 2.hemocrit 33%

2.Myeloid Growth Factor

G-CSF
GM-CSF
1. neutrophils
G-CSF
2. neutrophils

3. neutrophils
G-CSF GM-CSF mobilize PBSC ()

3.Megakaryocytes Growth Factor

TPO IL-11