s = act Ectasia (Periductal Mastitis) nition ¥ common disease of extralobular ducts with irregular pperiducta fibrosis, and/or inflammation. vonyms ‘mastitis, plasma cell mat s.comedo mastitis, mast stogy and Pathogenesis exist (1, 5,6, 14]: ‘lsetion as th ila phe ofthe divtse do vo ‘ne abnormalities (hyperpolatnei?) tal ination, mot daca iltaton the iii ‘oti pthologial manifenation tthe disorder ty Wek eB procial vo intraductal proliferations ‘otra popiona 1ystic space or multiple dilated structures containing, reamy yellow to white material sometimes closely re- ‘comedo" necrosis [19]. Thickening and irregularity of nipple inversion are not infrequent (12,20, 1], sroscopic Features (Fig. 3) tal (large duct) lymphoplasmacytic infiltration ‘al fibrosis tr dilatation and obliteration of ducts lied foam cells (macrophages) in the ductal lumina; ‘hilic inspissated luminal contents neutrophilic granulocyte infiltration by acute phase of | bliteration of the ductal lamen by fibrous tissue, with te disappearance ofthe epithelial lining (mastitis oblit- atthe end stage alization” of obliterative diet eetaila: epithelial regen- of the occluded duet, forming 4 single channel or 4 channels with penetration longitudinally into the incu bina scare in combination: in practice, fas SSE BO OU wey or topes nek im the same breast [1,6,19]= ooo RE 11. once Ro hg om Apr ert LSS SSS nb aos ic dine cso pa tome tie ac ti ter ac 1 [No nipple discharge “Nipple eischarge in about 20% of hore with clinical disease tonto ncn prince commen dt pt tetany in enti ‘ay pia ro wnton Cin besnoatnd et elperie tay at pei Cnemntedorenidehtnyonntomn conga aed ac ith non ny in Shee rena ppc Src Porc oronienyoy tome pe ence wt ‘yen dc wl ne feign acne sown ey sega nee, ‘tna ipa Duct ectasia (periductal mastitis) differs from (fibroicystic, change clinically, histopathologically, pathogenetically, and probably aso etiological. Duct ectasa can be associated ‘with nipple abnormalities and may clinically simulate carcino ‘ma, Pathologists should not misinterpret duct ecasia as FCC 10,7,9,10,12,16,20) (see Table 31).