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    Muhammad Suwardoyo
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    genetika

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    genetika 2 1

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    genetika

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF or read online from Scribd
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    7 views8 pages

    Genetika 2 1

    Uploaded by

    Muhammad Suwardoyo
    genetika

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF or read online from Scribd
    Flag for inappropriate content
    of 8
    er Sess in pies cteomciomal pro. Bp eae of pariclar Se like BNA during "When coronatn from sei amc —e et ie te conpletan of Fase no histone mith pbescces ar removed am "sepces wit acne me Sphase chromatin. and ga tracer nro On nether tand hen tte nonhisines in consid chromatin ae fram UGpphase elle and the DAA and hetones 2 fam phate cel, na histone miNA ss smbestaed. These als idee hat the nachisione pretense che trai determine wher she peses coding for hs tones are transcribed eens key eefee ht the nomhisione chen perce play pont thle in the eeguaton of poe expresso in uk res Evidence ofthis pe cers doesnot excite the avoltemect of hitomes i the cepa oH Serpion The regula oftanscoptios nekaryors fnat well sneoke specie mentions among DNA, Fones, and nenbisone ceomesomal proens “ preien) coe cat excice the pesibiy tat fisone modifiouons or sonhtone Cronus eins re moved in same -spets of ee: Fepulated gene espresion ‘On te ober Tand, the teenth calabro dae sey umgests hat Fomone-reseior protein compleses ether sepnscnne Is rveramng dees wh pectic ENA Sequences present thin the eshunee Or promot feguone tar teplae the eames Of 1M tel genes Stone edence in upper of a dre mei fon benween the complex av ct-acing egulaory seuences of target genes avalaoe for te glo forteands (wich stimulate increases in bleed suze {eb the extagen: (shh steuate the develop ser ofthe feriale sex phenerype), sd Une ay hormones (sich contol Basal meabobie Qe) Sateen ott stn proce agentes of isi ster homones at dcr ar of oboe ges (9G cls of vas thes Ofen,& gren ‘eto ormore wilh ier elles ox dierent teligpes shag Ge mchanims by whiny on ot Mhesterod emooes at ate sll unisown, spec SXepid hormones such the ghicrorecids (8 carisol) and te enrages (eg, Betatil) tave fcr shown wo ane specie tres genes DFO: ‘eremedaigd ineratiom wih cleaag, epulaory Spence: These cranny sopienes ae stl Gale ernances ees tra Cy ier om the Shasial ernarcee im tat they eet tension feom nearby promoets only ten hormene-rexp torprotem comple: oe Pound lo hem “The alocroricidhocmowes protige the best ocumented exmele of sera. hormone aerated fee exression The close cf hiocoreoid or {hones Hive been aarti» sete Nor tree eile cexanetacme. Tae aaa ofthis Spec horone fa fated the peparaucn ot Glucocorticoid Hormones Aet via Enhancer Elements ae labeled hormone substrates fr fealztion anc bind Ing studies and for so studies on eanscrimien of cloced ager genes. The gucoconicoe horns act fy rst binding so 4 receptor pret Gat is presen the gtoplasm of ager calls. The hormone-recepror peaein compler then acumultes in ell eae and bisis to specific DNA sequencescalled glucocorticoid response elements (GRED, In the dzence of her ‘one, the receptor poten is asocaed with archer ‘toplasmie protein and has low afin for Dh The {Raluble endence suggess tha the asocated c70- plaumic protein presents the recep: preven (om Forning a dimes, which is believed m be the active, [DNtlainding form of dhe cecepce Presumably, the birding of Hormone causes at allones'= conforma ‘ional change inthe reeeptor prten so chat no Toeger bus tothe ytopbsmc prose The Feceptoe pesein can then dimerize to ts active for “The glucteoniond hormone-receper conmples acucues transcription of target genes by indi 2 GEE sequences in enfagcers cated cur exc) of shoe genes (Fig. 15.28). Bindng oF the horinone= rece soe te the enone fm urn acavaes the pro mote ofthe adacent amet enes. sinc i ees Sham by Whi enhances ate sama scrip. ica Uf feyaediag genes sll unceroa dal ‘Sone “hormone atvaton of gene exp.essen. ce trons (9 be elucdited, Cleary, the binging of the Freemone-receaor complex 1)'the enhancer must somehow peruce ape promaers Bat fate RNA elymerasekading and vanscpion Thisme ici Ioles some meshanism of enhancement of local laed unwind?g ofthe two DNA stands the pro: ‘rote epon, bu exelyhow tis ours is usknown, The bormone response elements ta bind der ect sere heemone-teepeor protein complexes con- ‘ain cflerent DNA sequences a cul be expeces Shice dine ses genes respond m each hocnone for example, the hormone Fesporee elemens core ‘rneenaus sex ences forglucosortcci, erga, anc {Eyroid hormones ste 9'GGTACANINTGITCT 5,5 GGTEANNNTE(ATICG, and 5°-CAGGGACOTAC SSCoS, respectively. interesingly, whee te ame aod sequences of eight difeen: Ser0id Soemone receptor proeins were compated, dy allexhibted 2 ‘mils organization. The Naermina region ofthese feat protets are responsibe: for We aerator of fone epressinn once the hornone-receso:cempler Fis boend othe appropnatenormone cesponse ee rent of the enhancer region. Tse reions ofthe [ceptor protems ate tghlyvarkade © oe would expec since the diferent hormones achatedferert penes The cena regions of de vecepor pres ‘anain the DNAbinging domains, and these regions Sr lghy camerved Wi or 42 9 peceat alo to these accent erpor poe cembe nds ‘enter . in sense lent (Gi) wii aTocargs re ce es) le ag ae

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