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  • Norepinephrine (NE) Epinephrine (E) Receptors

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    erwin sinaga
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    Norepinephrine and epinephrine are catecholamines that bind to adrenergic receptors. Norepinephrine is released by sympathetic nerve endings, while epinephrine is produced in the adrenal medulla and acts as a hormone. There are two main families of adrenergic receptors: alpha and beta receptors. Alpha receptors can be further divided into alpha1 and alpha2 subtypes, while beta receptors are beta1 and beta2. These receptors activate different intracellular signaling pathways and have distinct effects on metabolic processes.

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    Norepinephrine

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    Norepinephrine and epinephrine are catecholamines that bind to adrenergic receptors. Norepinephrine is released by sympathetic nerve endings, while epinephrine is produced in the adrenal medulla and acts as a hormone. There are two main families of adrenergic receptors: alpha and beta receptors. Alpha receptors can be further divided into alpha1 and alpha2 subtypes, while beta receptors are beta1 and beta2. These receptors activate different intracellular signaling pathways and have distinct effects on metabolic processes.

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    © All Rights Reserved
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    7 views15 pages

    Norepinephrine (NE) Epinephrine (E) Receptors

    Uploaded by

    erwin sinaga
    Norepinephrine and epinephrine are catecholamines that bind to adrenergic receptors. Norepinephrine is released by sympathetic nerve endings, while epinephrine is produced in the adrenal medulla and acts as a hormone. There are two main families of adrenergic receptors: alpha and beta receptors. Alpha receptors can be further divided into alpha1 and alpha2 subtypes, while beta receptors are beta1 and beta2. These receptors activate different intracellular signaling pathways and have distinct effects on metabolic processes.

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    © All Rights Reserved
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    of 15

    Norepinephrine (NE)

    Epinephrine(E)
    Receptors
    By

    Gl Gnay
    Sevilay Akkse
    Gzde olak

    Norepinephrine, epinephrine, are


    in the class of catecholamines
    and they bind to adrenergic
    receptors.

    Norepinephrine (noradrenalin)
    Released by the sympathetic

    postganglionic nerve endings


    5

    HO
    HO

    6
    1

    CHOH

    CH2

    NH2

    Epinephrine (adrenalin)
    A methyl derivative of norepinephrine. It

    is

    primarily an emergency hormone


    produced by the adrenal medulla.
    5

    HO
    HO

    6
    1

    CHOH

    CH2

    NHCH3

    Sympathetic
    Division
    Both NE and E affect
    sympathetic nerves
    -NE is neurotransmitter
    -E is hormone
    z

    z
    z

    Increase heart rate and


    strength of contraction
    Mobilize glucose from liver
    Inhibit digestive activity

    Synthesis of E and NE

    Adrenergic Receptors

    Seven-pass
    transmembrane
    proteins that are
    coupled to G proteins
    There are multiple
    receptor types which
    are differentially
    expressed in different
    tissues and cells.

    Two main families of adrenergic receptors


    z
    z

    Alpha ()
    Beta ()

    NE,E

    Adrenergic
    Receptor
    Subtypes

    Main Type of Adrenergic Receptors

    Receptor

    Agonists

    Second Messenger

    G protein

    alpha1 (1)

    E>NE

    IP3/Ca2+; DAG

    Gq

    alpha2 (2)

    NE>E

    cyclic AMP

    Gi

    beta1 (1)

    E=NE

    cyclic AMP

    Gs

    beta2 (2)

    E>>NE

    cyclic AMP

    Gs

    1-receptor

    2-receptor

    (IP3, DAG)

    ( cAMP)

    Process

    1receptor
    ( cAMP)

    2-receptor
    ( cAMP)

    Carbohydrate liver
    No effect
    metabolism
    glycogenolysis

    No effect

    liver/muscle
    glycogenolysis;
    liver gluconeogenesis;
    glycogenesis

    Fat
    metabolism

    No effect

    lipolysis

    lipolysis

    No effect

    Hormone
    secretion

    No effect

    insulin
    secretion

    No effect

    insulin and glucagon


    secretion

    References:

    http://www.bio-logicsolutions.com/neurolog.htm
    http://www.neuro.wustl.edu/neuromuscular/lab/catechol.
    htm#ne
    http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocri
    ne/adrenal/medhormones.html
    http://www.blackwellpublishing.com/matthews/neurotran
    s.html
    http://www.blackwellpublishing.com/matthews/neurotran
    s.html
    http://www.creighton.edu/~tpisarri/Powerpoints/Lecture1
    1.ppt#339,25,Adrenergic Receptors
    http://www.sosu.edu/faculty/mturnage/Fall%2003%20fol
    ders /

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