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Edexcel Unit 1 The Risk of Developing CVD PDF
Edexcel Unit 1 The Risk of Developing CVD PDF
There are some risk factors involved with CVD that can be controlled via changes to a persons lifestyle, while
there are also others which are beyond their control. Three of the main examples involving factors that affect
the development of CVD include genetic inheritance, the age of the person and their sex.
Firstly with genetics, it has been proven by certain studies that through inheritance of particular genes, some
families/ethnic groups may be more or less likely to develop a CVD. The tendency varies, where for some the
problem may be that they develop hypertension (high blood pressure) more readily causing damage to the
arteries and increasing the likelihood of CVD. Additionally others may have inherited weaknesses in the
biochemistry of their arteries, causing them to be damaged more easily, as well as negative inherited effects
hindering the metabolism of cholesterol (important lipid for bodily processes, but excessive amounts can lead
to atherosclerosis). Concerning genetics and certain groups, diabetes can also indirectly affect the risk of
developing CVD with around 65% of diabetics die of some form of CVD. Diabetes tends to be related to
specific ethnic groups (e.g. in America Native Americans) which can pass on inherited genes that increase
incidence of this.
Concerning age, the older the person gets the more the blood vessels begin to lose their elasticity and start to
narrow. This increases the chance of a person developing CVDs, as their veins and arteries have less space (in
the lumen) through which blood can travel through. With this, the hearts walls thicken and because of the
narrowing vessels it is more difficult for it to pump blood to the rest of the body and the muscles. Older age is
recognisably a significant risk factor for CVD, especially heart disease, where 4 out of 5 deaths caused by it
occur in those aged above 65 years.
Depending on whether a person is male or female could also affect their chances of developing a CVD. This is
noticeable where men under the age of 50 are more likely to suffer from CVD than woman of similar ages. An
explanation for the low incidence in younger woman can be seen where the female sex hormone oestrogen is
produced in woman of such ages. It has an important role in the menstrual cycle and is associated with a
reduction of plaque build up. This protection from CVD continues until the menstrual cycle ends with the
menopause (at around age 50) and oestrogen levels start to fall.
In addition to inherited factors, there are also other lifestyle factors that can affect the risk of developing CVD
which can be controlled to some extent. The first of such factors would be exercise, which is important as the
heart is a muscle and in this sense it becomes stronger and more efficient the more it is used through exercise.
The effects of exercise include the slowing of the heart rate, the lowering of blood pressure and lower blood
cholesterol levels. All of these additional factors from exercise can lower the risk of developing a CVD.
Associated with exercise, weight would be another risk factor where being overweight puts an increased
strain on the heart because it needs to work harder in order to pump the blood through the extra tissue
gained. An overweight person has a higher chance of developing other problems that increase risk of CVD,
such as high blood pressure and high blood cholesterol. Being overweight tends to have only a small impact on
the risk of developing a CVD where what is significant would be the levels of exercise and different fats in the
blood that are the best predictors of CVD.
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A contributing factor for heart disease is stress, where it considered having an effect on the heart even though
there is still little known about its direct effects. Such stress would be sourced from emotional stress,
behaviour habits and socio-economic status- all of which could possibly have varying effects. Such effects have
not actually been proven, as the way in which stress affects us can vary between people. One link between
stress and its affects on the heart would be where stressful situations raise heart rate and blood pressure,
thus increasing the hearts requirement of oxygen. A prolonged and excessive need for oxygen can bring about
angina or chest pain, something people who already have heart disease are likely to suffer from.
Additionally in times of stress the nervous system releases extra hormones (usually adrenaline) which can
raise blood pressure and possibly cause damage to the lining of the arteries. As the arteries heal from such
damage the walls may harden which can make it easier for plaque to build there.
With particular diets being a risk factor, fatty meat and foods (with saturated fats) are recognised by some
scientists as increasing the incidence of heart disease where people of certain countries that consume large
amounts of these die more of heart disease. Involving the high levels of saturated fats, these may be a risk
factor in diet. Associated with intake of saturated fats would be high blood cholesterol levels. Cholesterol is
involved in the development of atherosclerosis, which suggests a connection between a high-fat diet and
developing a CVD.
Related to cholesterol in the blood are two lipoproteins (both lipid and protein) in the body that are linked
with fat in the diet. The first, formed from saturated fats, cholesterol and protein would be low-density
lipoproteins LDL. They contain a relatively large amount of cholesterol and can bind to cell membranes before
they are taken into cells. If levels of LDL are high the membranes become saturated and so more LDL
cholesterol remains in the blood. Alternatively formed from unsaturated fats, cholesterol and protein are the
High-density lipoproteins HDL, which carry cholesterol from body tissue to the liver where it is broken down.
This usually helps where it lowers blood cholesterol levels and removes cholesterol from fatty plaques held on
the arteries. This is useful where it can lower the risk of heart disease from the condition of atherosclerosis.
Connected to the diet, there are certain drugs that have associations with the development of CVDs.
Firstly with alcohol, studies have shown that the risk of heart disease in people who didnt drink alcohol was
slightly higher than those who drank moderate quantities. Even though this is a positive aspect of alcohol
consumption, drinking more than the moderate amount of alcohol (2 drinks e.g. one drink = 4 fluid ounces of
wine / 12 fluid ounces of beer) can cause high blood pressure and cardiomyopathy (disease of the heart
muscle). Alcohol also usually contains large numbers of calories, which from it can add fat to body and increase
the risk of heart disease.
Secondly with tobacco, which greatly increases the risk of heart disease where the chemicals contained within
it, that are released when smoked, have many harmful effects. These would include the increasing of the heart
rate where major arteries are tightened and the development of irregularities in heartbeat timings, all of
which can cause the heart to work harder. Smoking tobacco also raises blood pressure and increases the risk of
CVD in those who already have high blood pressure. Chemicals in tobacco such as tar and carbon monoxide
are harmful to the heart on their own, where they lead to fatty plaque building up in the arteries and possibly
injuring the vessel walls. Additionally they can affect the levels of fibrinogen (blood-clotting material) and
cholesterol, both of which can increase the risk of a blood clot leading to a heart attack.
Lastly with drugs, birth control pills contain high levels of both estrogen and progestin. The consumption of
these increases the chance of heart disease, especially in woman older than 35 with the additional risk factors
such as smoking. Related to CVD, birth control pills tend to be considered safer in recent times, where
developments have led to lower doses of hormones contained within them.
Statins
These are a group of drugs that lower the level of cholesterol in the blood, where they block the
enzyme in the liver that is responsible for making cholesterol and are effective in preventing the
production of low-density lipoproteins. Statins are effective in reducing inflammation of the artery
lining by improving the balance of LDLs to HDLs. Both the functions of statins can help to reduce the
risk of developing atherosclerosis.
There are possible side-effects of using statins, which include muscle and join aches, nausea,
constipation and diarrhoea. In addition to these there are two more serious and rare side-effects. In
some people statins can result in a form of fatal muscle inflammation and some may develop liver
damage from their use. Some other risks include the consumption of statins to lower blood
cholesterol, which could sometimes cause people to no longer attempt to have a healthy diet
because they overestimate its effects, which could result in an unhealthy diet because of their
assumptions about statins. Additionally statins reduce the absorption of certain helpful vitamins
from the gut.
Plant stanols and sterols
These are not necessarily drugs, where they are mostly sold in certain foods such as yoghurts and
spreads. These are effective where they reduce the quantity of cholesterol absorbed from the gut
into the blood. This makes it easier for the body to manage cholesterol and reduces the levels of
low-density lipoproteins in the blood. The benefits are recognisable with research results showing
that if eaten regularly in recommended amounts they do work, and can possibly lower the risk of
heart disease by 25%. The risks of consuming such plant stanols and sterols are not evident, where
they do not have any noticeable side effects, though they should still be taken in moderation for
dietary purposes.