Drug metabolism

Stimulation many lipid soluble drug cause non-specific stimulation of drug

metabolism in both humans and experimental animals. The number of drugs shown
to be inducing agents in humans is relatively small (see Table 7).banyaknya
rangsangan obat yang larut dalam lemak menyebabkan rangsangan obat yang
tidak spesifik terhadap manusia maupun hewan. Jumlah obat yang mempengaruhi
dalam manusia relative sedikit (lihat table 7). The administration of an inducing
agent stimulantes not only the metabolism of many drug and physiological
compounds which are substrates for micosominal enzymes but also the metabolism
of inducing agent It self. Pemberian stimulasi agent untuk mempengaruhi tidak
selalu memetabolismebanyak obat dan ikatan yang mana substrat dari enzyme
micosominal tetapi juga metabolism dapat mempengaruhi agent itu sendri.
Microsomal enzim inducing occurs in many tissues gut wal, lung, kidney, skin, as
wel as the liver.

Interactions at receptors
They are many example of pharmacodynamic interaction where one drug alters the
effect of another by virtue of is greather affinity for receptor site. Banyaknya contoh
dari interaksi farmakodinamik dimana sebuah obat mengubah effek yang lain
dengan affinitas lebih besar terhadap reseptor. The antagonism of warafin by
vitamin K, of morphine by naloxone, of acetylcholine by tubocurarin, or atropine,
and of dopamine by chlorpromazine are all such example. Antagonis dari warafin
dengan vitamin K, morpin dengan naloxone, acetylcholine dengan tibocurarin,
atau atropine, dan dopamine dengan chlorpromazine semuanya adalah contoh. The
receptors concerened are better defined in some instance than other. reseptor
prihatin lebih dari menggambarkan dalam jumlah hal dari yang lain . in some
instance the underlying mechanism is slightly more complicated. The muscle
relaxation produce by tubocurarine can be reversed by neostigmine which in hibits
cholinesterase and thus increasethe concentration of acetylcholine ate nerve
endings,
Iderference with intracellular transport mechanism constitute a