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IN T R O D U C T IO N

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a n d

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th e n i n e te
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al
w ith t h e n a t u r a l
p r o d u c t , o r o f a d r u g w i th a l te r a t io n s in c h e
m ic a l
s tr u c t u r e w h ic h r e s u l t in a s u b s ta n c e w h ic h in s
o m e w a
y im p r o v e s
o n n a tu r e
th e s y n t h e tic m a y fo r in s ta n c e b e m o r e
p o te n t th a n th e
o r i g in a l p la n t e x tr a c t , o r h a v e fe w e r u n to w a r d e f fe c
ts T h e
p ha r
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a n d o p ia te s p r o v id e s a n e x a m
p
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t y p e o f g e n e r a l te c h n o lo g ic a l s e q u e n c e

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v id e d

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N T R O D U C T IO N

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th e n te r m e d th e s t im u la n t u s E o f th e d r u g T h e s e tw
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l
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n
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g
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d o p i n g , t h e u s e o f o p i u m b y R o m a n ti c p o e ts a n d F e n la n
d la b
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rs
th e e n o r m o u s a n d u n c o n tr o ll e d s a le o f o p i u m a s a
,
p o p u la r r e I
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o r th e m e d ic a l u ti l i ty o f th e d r u g
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actt
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n in e t e e n t h

c e n tu ry

o w l e d g e o f th e u t ili ty o f o p i u m

w a s n o t,

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T h e p r o p e r ti e s o f th e d r u g , a n d its u s e s ti m
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R e fe r e n c e s to th e u ic e o f t h e p o p p y ' o c c u r in
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A s s y r a n m e d i c a l ta b l e ts o f th e s e v e n th c e n t u r y B c
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