1.

(anti-diabetic drugs)
first generation of sulfonylurea
pka 2 pka1 = 3.96 0.11
pka2 = 6.20 0.05

2.

. A C

. B

. A aromatic affinity

. C bioavailability

.
3. hypothyroidism

. deamination
decarboxylation
.
Polarimeter
. (ether) h-bond acceptor
receptor
. glucuronide conjugation

. conformation

4. PPAR agonist

Tesaglitazar

Muraglitazar

. tesaglitazar
pka

. Muraglitazar tesaglitazar
. reuptake
glucose insulin
.

.
5.

. C1 antiinflammatory activity
. 11--OH glucocorticoid activity
. 17--OH glucocorticoid
mineralocorticoid activity
. 6--F 9--F glucocorticoid
mineralocorticoid activity
.
6. estrogen

. aromatic ring 3-OH

. 1
estrogenic effect
. hydroxyl 17
beta estrogenic effect
. steroid

. alkylation 17-alpha

7.




2 kg oral
combine contraceptive

8. progesterone

.
. duration