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Research Article
Dhiman et al.
Asian J Pharm Clin Res, Vol 5, Suppl 1, 2012, 45-49
factors which influence the release of the drug from the matrix 22.
The polymer HPMC K15M is used in the matrix system which
enables the slow release of drug from the matrix system. Various
concentrations (10, 20, 30 mg) of the polymer are used in the
floating tablets to check the effect of the concentration of the
polymer on release characteristics. Sodium bicarbonate is also used
in different concentrations to check the effect of the CO 2 forming
agents.
F1
F2
F3
F4
F5
F6
F7
F8
F9
F10
F11
F12
F13
40
10
10
2
1
2
135
200
40
20
10
2
1
2
125
200
40
30
10
2
1
2
115
200
40
10
15
2
1
2
130
200
40
20
15
2
1
2
120
200
40
30
15
2
1
2
110
200
40
10
20
2
1
2
125
200
40
20
20
2
1
2
115
200
40
30
20
2
1
2
105
200
40
20
15
2
1
2
120
200
40
20
15
2
1
2
120
200
40
20
15
2
1
2
120
200
40
20
15
2
1
2
120
200
X1
F1
-1
F2
-1
F3
-1
F4
0
F5
0
F6
0
F7
+1
F8
+1
F9
+1
F10
0
F11
0
F12
0
F13
0
Translation of coded levels in actual units
Coded level
-1
X1: HPMC K 15 M (mg)
10
X2: Sodium bicarbonate (mg)
10
Design Experimental Design.
X2
-1
0
+1
-1
0
+1
-1
0
+1
0
0
0
0
0
20
15
+1
30
20
46
Dhiman et al.
Asian J Pharm Clin Res, Vol 5, Suppl 1, 2012, 45-49
pore formation, which led to rapid hydration of the polymer matrix
and thereby to rapid drug release.
Table 3: Response Parameters of various Formulations
Prepared as per the Experimental Design.
Formulation
Code
F1
F2
F3
F4
F5
F6
F7
F8
F9
F10
F11
F12
F13
Floating
(sec)
39
24
15
23
11
9
28
7
5
10
9
12
11
lag
time
t50 (hrs)
8
6.1
5.5
7.2
5.8
4.9
6.5
5
4.3
5.6
5.9
5.7
5.5
47
Dhiman et al.
Asian J Pharm Clin Res, Vol 5, Suppl 1, 2012, 45-49
Table 4: ANOVA Influence of formulation variables on the response factors.
Response factor
Model
F-value
Prob> F
Lack of fit
F-value
Prob> F
31.93
0.38
4.55
<0.0001
Significant
0.0362
Significant
0.5694
Nonsignificant
0.9954
Nonsignificant
Lag
Std.
Dev.
1.07
0.9952
Adjusted
R2
0.9885
Predicted
R2
0.9448
in
0.73
0.7648
0.5967
0.6330
Design-Expert Software
Factor Coding: Actual
T 50
Design points above predicted value
Design points below predicted value
8
3.6
X1 = A: HPMC K15 M
X2 = B: Sodium Bicarbonate
7
6
T 50
Response
Factor
Floating
Time
Response
Time, t50
R2
0.020
F lo a tin g la g tim e
X1 = A: HPMC K15 M
X2 = B: Sodium Bicarbonate
14.00
B: Sodium Bicarbonate
A: HPMC K15 M
Design-Expert Software
Factor Coding: Actual
T 50
Design Points
8
3.6
X1 = A: HPMC K15 M
X2 = B: Sodium Bicarbonate
T 50
20.00
18.00
16.00
5
6
14.00
10.00
10.00
15.00
20.00
25.00
30.00
A: HPMC K15 M
10
0
30.00
15.00
12.00
10.00 10.00
A: HPMC K15 M
20.00
18.00
16.00
5
14.00
25.00
20.00
14.00
B ic a rb o n a t e
10.00 10.00
20
B: Sodium Bicarbonate
B : S o d iu m
15.00
12.00
30
16.00
20.00
40
18.00
X1 = A: HPMC K15 M
X2 = B: Sodium Bicarbonate
25.00
16.00
12.00
20.00
Design-Expert Software
Factor Coding: Actual
Floating lag time
Design Points
39
30.00
18.00
B : S o d iu m
20.00
B ic a rb o n a t e
4
3
Design-Expert Software
Factor Coding: Actual
Floating lag time
Design points above predicted value
Design points below predicted value
39
CONCLUSION
It is concluded from the present investigation that effervescentbased floating drug delivery is a promising approach to achieve in
vitro buoyancy by using gel-forming polymer HPMC (K15M) and gasgenerating agent sodium bicarbonate. HPMC (K15M) containing
floating matrix tablet of famotidine was promising controlled release
systems for peptic ulcers. The optimized formulation gives the best
result in terms of the required lag time (5 seconds) and floating
duration of 10 hours with sustained drug release rates. A central
composite design was applied to investigate the combined effect of
three formulation variables. Results of multiple regression analysis
indicated that moderate level of all three independent variables is
useful for development of gastroretentive drug delivery system.
10
REFERENCES
20
1.
12.00
30
10.00
10.00
15.00
20.00
25.00
30.00
2.
A: HPMC K15 M
3.
48
Dhiman et al.
Asian J Pharm Clin Res, Vol 5, Suppl 1, 2012, 45-49
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
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