Professional Documents
Culture Documents
Disclosures
Objectives
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Experience,
Breathe-out Poetry.
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A
Profoundly
Sick
Society
Man's
dilemma
now and
always has
been that he
misidentifies
his own
intellectual
artifacts as
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Experience,
Breathe-out Poetry.
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Joseph Campbell
This thing up here, this
consciousness, thinks
it's running the shop. It's a
secondary organ. It's a
secondary organ of a
total human being, and
it must not put itself in
control. It must submit
and serve the humanity
of the body.
The Power of Myth (1988)
BJ Palmer
"But when education
becomes egotistical and
paramount and displaces
the correct values of Innate,
all else becomes
"uneducated", sub-conscious,
non-conscious, and unconscious.
Education then becomes an
impenetrable wall Innate
does not and cannot break
through."
The Bigness of the Fellow Within. p. 18.
Video Follows
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Why do we
think about
cancer the
way that we
do? Are We
Focused on
the Right
Things?
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Leukemia
Some physicians
(Virchow) in the 1800's
published case reports
on patients with way too
many white blood cells.
Patients with leukemia
can have white cell
counts as high as
several
hundred
Recall that,
survivors of poison gas attacks during
thousand.
thousand
WWI,
often had close to zero WBC counts.
counts
Davis. The Secret History of the
War on Cancer. 2007. p. 201.
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Experience,
Breathe-out Poetry.
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Defining Cancer
Cancer is not
just one disease
but many
diseases.
There are more
than 100
different types
of cancer.
http://www.cancer.gov/cancertopics/what-iscancer
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Cancer is a Preventable
Disease
Only 5-10% of all cancer cases can be
attributed to genetic defects, whereas the
remaining 90-95% have their roots in the
environment and lifestyle.
Common environmental factors that lead to
cancer death include: tobacco (25-30%),
diet and obesity (30-35%), infections
(15-20%), radiation, stress, lack of physical
activity, and environmental pollutants.
Pharm Res. 2008 Sep;25(9):2097-116.
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Cause of Cancer
Cancer is
fundamentally a
disease of
regulation of tissue
growth.
In order for a normal
cell to transform into a
cancer cell, genes
which regulate cell
growth and
differentiation must be
altered.
N Engl J Med. 2008 Jan 31;358(5):502-11.
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Hmmmmmmmmmm
If cancer is a
problem of cell
growth and
regulation, then what
is required to help a
cell remain a fully
functioning, normal,
healthy cell?
How does one avoid
dysplasia or a
maturation
abnormality?
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Cellular Abnormailites
Dysplasia, a maturational abnormality, is often
indicative of an early neoplastic process.
Metaplasia is the
reversible
replacement of one
differentiated cell
type with another
mature
differentiated cell
type.
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Anaplasia
The term
anaplasia literally
means "to form
backward".
It implies
dedifferentiation,
or loss of
structural and
functional
differentiation of
normal cells.
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Breathe-in
Experience,
Breathe-out Poetry.
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Video Follows
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65
Shift-Work is Carcinogenic
(Reuters) - Shift workers
and firefighters have a
higher risk of cancer
than the general
population and such
work should be
classified as probably or
possibly carcinogenic,
the International Agency
for Research on Cancer
said on Friday.
By Maggie Fox, Health and Science Editor
WASHINGTON | Fri Nov 30, 2007 1:57pm EST
http://www.reuters.com/article/idUSN3029736520071130
Light-at-Night Disruption
We conclude that circadian disruption induced by
light-at-night accelerates aging and promotes
tumorigenesis in rats.
This observation supports
the conclusion of the
International Agency
Research on Cancer that
shift-work that involves
circadian disruption is
probably carcinogenic to
humans.
Aging (Albany NY). 2009 Oct 2;1(10):855-65.
Epidemiologic studies
are now beginning to
emerge suggesting that
women who work at
night, and who
experience sleep
deprivation, circadian
disruption, and exposure
to light-at-night are at
an increased risk of
breast cancer, and
possibly colorectal
cancer as well.
Cancer Causes Control. 2006 May;17(4):539-45.
Shift-Work/Chronodisruption
Awake at Night
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Occupational Sunlight
Exposure and Risk of Cancer
Recent findings
indicate that
vitamin D obtained
from ultraviolet (UV)
exposure may
reduce the risk of
several different
cancers.
Cancer. 2010 Apr 15;116(8):2001-10.
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Cholecalciferol
Steroid Hormone
Produced in
response to light
Produced in
response to
darkness
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Experience,
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What is Melatonin?
Melatonin also known
chemically as Nacetyl-5methoxytryptamine,
is a naturally
occurring
compound found in
animals, plants, and
microbes.
http://en.wikipedia.org/wiki/Melatonin
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Serotonin-Melatonin Pathway
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Endocrine Melatonin
Melatonin produced
in the pineal gland,
which is outside of
the blood-brain
barrier, acts as an
endocrine
hormone since it is
released into the
blood.
http://en.wikipedia.org/wiki/Melatonin
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Paracrine Melatonin
By contrast,
melatonin produced
by the retina and the
gastrointestinal (GI)
tract acts as a
paracrine
hormone.
http://en.wikipedia.org/wiki/Melatonin
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Site of Action
G protein-coupled
receptor
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Melatonin is Melatonin
The melatonin
circulating in your
veins is chemically
the same as that
extracted from algae,
plants, insects, frogs,
and seals.
RJ Reiter and J Robinson. Melatonin. 1995.
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Melatonin in Plants
Melatonin in plants
has multiple roles
including regulation
of the
photoperiod, in
plant defense
responses, and as a
scavenger of reactive
oxygen species.
Journal of Experimental Botany 2009; 60 (1): 5769.
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Melatonin in Animals
[Melatonin] serves as a
biological signal for the
organization of
photoperiodic seasonal
functions such as
reproduction, behavior,
coat growth and
camouflage coloring in
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seasonal animals. 91
Melatonin Toxicity
Melatonin has a very low
toxicity in rats.
Rat maternal toxicity: the
no observable adverse
effect level (NOAEL) and
lowest observed adverse
effect level (LOAEL) were
100 and 200 mg/kg/day,
respectively, and the
developmental toxicity
NOAEL was >= 200
mg/kg/day.
Toxicological Sciences 1999;50(2):271-9.
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Anti-Cancer Effects of
Melatonin
antioxidant effects
regulation of the
estrogen receptor
expression
modulation of the
enzymes involved in
the local synthesis of
estrogens
modulation of cell
cycle and induction of
apoptosis
inhibition of
telomerase activity
inhibition of
metastasis
prevention of
circadian disruption
antiangiogenesis
stimulation of cell
differentiation
activation of the
immune system.
Curr Med Chem. 2010 Nov 10.
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Melatonin as Antioxidant
Melatonin can easily
cross cell membranes
and the blood-brain
barrier.
Endocrine. 2005 Jul;27(2):119-30.
Is a suicidal or terminal
antioxidant which
distinguishes it from
the opportunistic
antioxidants.
Biol Signals Recept. 2000 May-Aug;9(3-4):137-59.
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An Established Antioxidant
Worthy of Use in Clinical Trials
Accumulating
evidence suggests
that this nontoxic
indolamine may be
useful either as a
sole treatment or in
conjunction with
other treatments for
inhibiting the
biohazardous actions
of nitrooxidative
stress.
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Melatonin inhibits
telomerase activity in the
MCF-7 tumor cell line both in
vivo and in vitro.
Telomerase is an enzyme
responsible of telomere
elongation and is activated
in most human cancers.
J Pineal Res. 2003 Oct;35(3):204-11.
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In summary,
agomelatine has
unproven efficacy and
poorly documented
adverse effects.
Prescrire Int. 2009 Dec;18(104):241-5.
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http://www.rozerem.com
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Pharmakos (Greek: )
The term "pharmakos"
later became the term
"pharmakeus" which
refers to "a drug, spellgiving potion, druggist,
poisoner, by extension
a magician or a
sorcerer."
Jim Lynn, The Miracle of Healing in Your Church Today. p.93
Scapegoat
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Believing that a
pharmaceutical can heal your
body ...
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Experience,
Breathe-out Poetry.
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What is Vitamin D?
Vitamin D (calciferol)
comprises a group of fat
soluble seco-sterols
found naturally only in a
few foods, such as fish-liver
oils, fatty fish, mushrooms,
egg yolks, and liver.
The two major
physiologically relevant
forms of vitamin D are D2
(ergocalciferol) and D3
(cholecalciferol).
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Where is Vitamin D
Synthesized?
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Vitamin D is a Hormone
Active vitamin D functions as a hormone, and its main
biologic function in people is to maintain serum calcium and
phosphorus concentrations within the normal range by
enhancing the efficiency of the small intestine to absorb
these minerals from the diet (DeLuca 1988; Reichel 1989).
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Canonical Vitamin D
1.Skin-LiverKidney
Activation
2.Endocrine
Function
3.Enteric
Calcium
Binding
Protein
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4.Enteric
Calcium
Channel
115
Non-Canonical Vitamin D
1.Peripheral Tissue
Activation
2.Paracrine Function
3.Human ProtonCoupled Folate
Transporter
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Role of Folate
Folate is necessary
for the
production and
maintenance of
new cells, for DNA
synthesis and RNA
synthesis, and for
preventing
changes to DNA,
and, thus, for
preventing
cancer.
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Vitamin D-Folate-Melatonin
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Betaine/Betaine-Homocysteine
Methyltransferase
The original betaine (bee' ta een), N,N,Ntrimethylglycine, was named after its discovery in
sugar beets (Beta vulgaris) in the 19th century.
Intracellular accumulation of
betaine protects protein structure
and membrane integrity while
preventing cellular dehydration.
It is also a methyl donor of
increasing significance.
http://en.wikipedia.org/wiki/Betaine
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S-Adenosyl Methionine
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HIOMT/Hydroxylindole-O-Methyltransferase
HIOMT mRNA displays a day/night
variation,with a 2-fold increase in
nighttime levels.
This day/night variation persists under
constant darkness and is abolished
by light applied at night, indicating that
HIOMT gene expression is
controlled by the endogenous clock.
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Vitamin D-Folate-Melatonin
Connection
Vitamin D levels
increase
Folate absorption
Increases
Melatonin
Precursors
Assemble
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Melatonin is
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Experience,
Breathe-out Poetry.
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The Gift
128
http://bop.nppa.org/2009/still_p
hotography/winners/?
cat=UPS&place=3rd&item=14
0479
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In January
2009, Vibe lost
the fight
against cancer.
At the time of
her death she
was seven
years old.
http://www.bitemagazine.ne
t/2010/08/24/a-family-lifebetween-hospitalizationsand-chemotherapy/
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Is Sun exposure
Worth the Skin Cancer Risk?
The U.S. economic
burden due to vitamin
D insufficiency from
inadequate exposure
to solar UVB irradiance,
diet, and supplements
was estimated at $4056 billion in 2004,
whereas the economic
burden for excess UV
irradiance was
estimated at $6-7
billion.
billion
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Photochem Photobiol. 2005 Nov-Dec;81(6):1276-86.
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An Ethical Question?
The recent discovery that
supplemental cholecalciferol
(vitamin D) significantly
reduces all-cause mortality
emphasizes the medical,
ethical, and legal
implications of promptly
diagnosing and adequately
treating vitamin D deficiency.
Altern Med Rev. 2008 Mar;13(1):6-20.
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Percentage
37.5
Adequate is 30 ng/mL or
higher (73 nmol/L).
38.5
n = 512
30
24
20
10
Vitamin D Status
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2.0
n = 512,
12 yrs
1.94
1.5
1.0
1.00
0.5
0.0
Sep/Oct;58:264-265.
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Low
Adequate
Breast Cancer
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Colorectal Cancer
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Disjunction
[D]isjunction,
consist[s] of
substantial
weakening or
loss of adherence
between epithelial
cells within a tissue
compartment.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Disjunction
Existence of the
capability of human
cells for disjunction
and rapid
autonomous
proliferation is not
surprising, since it is
needed for growth
and healing of
injuries.
Cell. 1996;84:345357.
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Disjunction
DNA may facilitate
the capability of the
human cell for
autonomous
decoupling from a
basement
membrane, and the
mobility that is
needed for
reproduction and
functioning of the
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cellular immune
Initiation
The critical events
are most likely
uncorrected errors
that occur during
DNA replication or, at
times, action on the
DNA of alkylating
agents, ionizing
radiation, or
epigenetic factors.
Br J Cancer. 2009;100:571577.
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Natural Selection
This phase consists
of selection of the
fastest reproducing,
most aggressive
cells.
It is a well described
process of evolution,
yet occurring on a
microscopic scale.
Land RB. Genetics and reproduction. In: Austin CR, Short
RV, eds. Reproduction in mammals: reproductive fitness.
Cambridge: Cambridge University Press; 1985:3
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Natural Selection
Since the driver of evolution
is the gene, a stem cell
having a gene associated
with faster reproduction or
aggression against other
cells in competition for
limited resources, will
eventually be
overrepresented in the
tissue compartment.
Dawkins R. The selfish gene. New York: Oxford University Press;
2006.
Nutr Rev. 2007;65:S9195.
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Overgrowth
The next phase is
clonal expansion, or
overgrowth of the
tumor outside the
basement
membrane of the
tissue and into the
stromal layer; it
occurs for unknown
reasons.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Overgrowth
Aggressive cells near
the basement
membrane may
begin to dissolve it
enzymatically or by
changing
extracellular pH, in
order to obtain
needed amino acids.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Metastasis
The next phase is
metastasis, which may
be regarded as
analogous to
colonization of a
remote range by an
organism.
Invasion of distal tissues
could be facilitated by
disjunction in the
remote tissue, reducing
its barrier function.
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Ann Epidemiol. 2009 Jul;19(7):468-83.
Involution
The next phase is
involution, which occurs
when vitamin D status
is restored by a
seasonal rise in
25(OH)D; it consists of
a temporary arrest of
growth of metastases
and other progeny of
the primary tumor
whose VDR is intact.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Involution
During the involution
phase, malignant cells
remain in the
metastases, but
intercellular
junctions may be reestablished in cells
that have functional
VDR.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Transition
If vitamin D and
calcium deficiency
persist and the
metastatic lesions do
not irretrievably
harm a vital organ,
the metastatic
cancer will make a
transition to
carcinomatosis, or
disseminated
malignancy.
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Transition
If vitamin D and
calcium are
repleted to
adequate levels,
some evidence
suggests that there
may be a
transition from an
acute to a chronic
disease.
Ann Epidemiol. 2009 Jul;19(7):468-83.
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Transition
[T]he VDR receptorligand complex
activates signaling
pathways that
induce E-cadherin
and other proteins
that adhere cells to
one another,
including zona
occludens proteins 1
and 2.
J Cell Biol. 2008;183:697710.
Anticancer Res. 2008;28:26132623.
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Breathe-in
Experience,
Breathe-out Poetry.
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Time Cycles
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Circadian (20 to 28
hours)
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Circadian Cycle
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Circadian Clock
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These rhythms
are the
outward
manifestation
of an internal
timing
system
generated by a
circadian clock
that is
synchronized
by the day164
night cycle.
Circadian Clock
The circadian timing
system proficiently
coordinates the
physiology of living
organisms to match
environmental or
imposed 24-hour
cycles.
Nat Rev Neurosci 2003 , 4:649-661.
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Circadian Clock
Circadian clocks are
endogenous and selfsustained timetracking systems that
enable organisms to
anticipate
environmental changes,
thereby adapting their
behavior and
physiology to the
appropriate time of day.
Trends Neurosci 2002 , 25:632-637.
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Circadian Clock
A wide range of
biological processes
are regulated by
the circadian clock
including sleep-wake
cycles, body
temperature, energy
metabolism, cell
cycle and hormone
secretion.
Annu Rev Genomics Hum Genet 2004 , 5:407-441.
Curr Top Dev Biol 2007 , 78:173-216.
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Master Clock
The mammalian
clock system is
hierarchical with a
master clock that
controls circadian
rhythms and resides
in the
suprachiasmatic
nucleus (SCN) of the
hypothalamus.
Journal of Circadian Rhythms 2010, 8:3
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Master Clock
The SCN pacemaker
consists of multiple,
autonomous single
cell circadian
oscillators, which
are synchronized to
generate a
coordinated rhythmic
output in intact
animals.
Neuron 1995 , 14:697-706.
Cell 1997 , 91:855-860.
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Master Clock
In mammals, the
circadian
photoreception
pathways are
distinct from those of
visual perception.
N Engl J Med 1995 , 332:6-11.
Science 1999 , 284:502-504.
Science 1999 , 284:505-507.
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Master Clock
Light is perceived by
a subset of
melanopsinexpressing retinal
ganglion cells, and
the photic
information is
directly conveyed to
the SCN clock
through the retinohypothalamic tract.
Nature Neurosci 2001 , 4:1165.
Science 2002 , 295:1065-1070.
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Retinal Melanopsin
Mutant mice lacking rods and cones (blind)
can, nevertheless, be entrained by light
dark cycles.
Koukkari and Sothern. Introduction to Biological Rhythms. 2006. p. 37
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SCN Environmental
Synchronizer
The suprachiasmatic
nuclei (SCN) of the
hypothalamus are
necessary for
coordination of major
aspects of circadian
rhythmicity in
mammals.
Brain Res Mol Brain Res. 2004 May 19;124(2):143-51.
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Master Clock
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Master Clock
In general terms, the
period of the clock
is genetically
determined,
whereas its phase is
heavily influenced
by environmental
zeitgebers (cues or
stimuli) such as light.
Journal of Circadian Rhythms 2010, 8:3
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Zeitgeber
The major zeitgeber
(time-giver) is light
intensity.
Other zeitgegers
include food,
temperature,
exercise, social
interaction and odor.
The zeitgeber uses the neuroendocrine system
to entrain slave oscillators.
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Slave Oscillators
A major finding in the
field of circadian
rhythms in recent years
is that the SCN is not
the only circadian clock
in the organism.
Indeed, most tissues
including extra-SCN
brain regions and
peripheral organs bear
circadian oscillators.
J Biol Rhythms 2003 , 18:250-260.
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Slave Oscillators
The SCN
synchronizes
peripheral
clocks in organs
so that a coherent
rhythm is
orchestrated at
the organismal
level to ensure
temporally
coordinated
physiology.
J Biol Rhythms 2001 , 16:196-204.
Cell Tissue Res 2002 , 309:109-118
Eur J Neurosci 1999 , 11:1535-1544.
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Molecular Mechanism
of the Circadian Clock
The molecular
clockwork is composed
of a network of
transcriptionaltranslational
feedback loops that
drive rhythmic, ~24hour expression
patterns of core clock
components.
Science 2000 , 288:1013-1019.
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181
Molecular Mechanism
of the Circadian Clock
Core clock
components are
genes whose
protein products
are necessary for
the generation and
regulation of
circadian rhythms
within individual cells
throughout the
organism.
J Biol Rhythms 2004 , 19:339-347.
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Circadian
Clock Genes
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Clock-Cancer Connection
Exposure to light-atnight, including
disturbance of the
circadian rhythm,
possibly mediated
via the melatonin
synthesis and
clock genes, has
been suggested as a
contributing cause of
breast cancer.
Journal of Circadian Rhythms 2010, 8:3
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Breathe-in
Experience,
Breathe-out Poetry.
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Entrainmen
t
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Entrainment
In chronobiology,
entrainment of a
circadian system is
the alignment of
its own period and
phase to the period
and phase of an
external rhythm.
http://en.wikipedia.org/wiki/Entrainment_(chronobiology)
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Chronobiologic Function
In animals,
circulating levels of
the hormone
melatonin vary in
a daily cycle,
thereby allowing the
entrainment of the
circadian rhythms of
several biological
functions.
Int. J. Clin. Pract. 2007; 61 (5): 83545.
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Time Schedules
Regardless of
whatever schedules
society imposes or
we impose, we are
born with a
temporal system of
rhythms as part of
our genetic structure.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 378
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Time schedules
Depending upon the
circumstances there
may be harmony or
discord between our
internal rhythms and
the external clocks of
our society.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 379
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Artificial Rhythms
Life moves in
synchrony to the
beat of clocks and
calendars, some
outside the body and
some within the very
cells of all living
things.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 1
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Watches, Clocks,
Calendars and Schedules
These independent
devices may be either
in or out of phase with
the biological clocks and
rhythms of our body,
which over millions of
years, have adapted to
the motions of our
planet with its
environmental cues as
to when an activity
should best occur.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 376
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Circannual Cycle
Light can
be used to
calculate
the time of
year.
Foster & Kreitzman from Life Rhythms,
2005, p. 84.
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Cultura Mata
Today, the trends in
urbanization and
the utilization of
electrical power
and rapid
transportation shield
most of us from
witnessing much of
the seasonal
biological diversity
found in nature.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 107
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Addaptaion to Light
Availability
Native plants and
animals have become
adapted to the
seasons of their
environment by
responding to the
changes in the lengths
of daylight and night
in preparation for
climactic changes that
are to come.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 109
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Photoperiodism
These responses,
which are associated
with the seasons of
the year, involve a
physiological process
known as
photoperiodism.
Koukkari and Sothern. Introduction to Biological Rhythms.
2006. p. 109
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Brain dopamine
systems are implicated
in a variety of
behavioral responses
and clinical syndromes,
including sex, drug
addiction, feeding,
satiety, sleep,
wakefulness, arousal,
attention, reward,
decision-making,
depression, anxiety,
psychosis, and
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movement disorders. 203
Dopamine: Modulator
of Food Seeking.
The dopamine
projection to the
nucleus accumbens
has been implicated in
behaviors directed
toward the
acquisition and
consumption of
natural rewards.
J Neurosci. 2004 Feb 11;24(6):1265-71.
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Addiction depends
on Speed of Reward.
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Reduced Motivation
In humans, drugs that reduce dopamine
activity (neuroleptics, e.g. antipsychotics:
clozapine, haldol) have been shown to
reduce motivation, cause anhedonia
(inability to experience pleasure), and longterm use has been associated with the
irreversible movement disorder, tardive
dyskinesia.
Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S181-90.
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Cortisol Hunger
In binge eating
disorder, there is an
hyperactive HPA
axis related to
abdominal obesity
that persists even
after treatment,
suggesting that
cortisol might be
a primary factor
in the disorder.
Ann N Y Acad Sci. 2004 Dec;1032:202-7.
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Cancers linked to
obesity among
women comprise
approximately 51%
of all new cancers.
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Light pollution
The prevalent trend in human society to use
artificial light has reached ruinous
levels throughout much of the world such
that nocturnal sky brightness has increased
many fold from natural conditions.
Illuminating the night and thereby
extending the daylong past sunset is an
ever increasing dilemma.
Koukkari and Sothern. Introduction to Biological Rhythms. 2006. p. 408
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Breathe-in
Experience,
Breathe-out Poetry.
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Prehibernation Insulin
Resistance
The bats showed high
circulating blood
glucose levels and
impaired glucose
tolerance during the
period of fat deposition
suggesting insulin
resistance condition
which improves after
winter when most of
the fat has been utilized
as a metabolic fuel.
Comp Biochem Physiol A Mol Integr Physiol. 2010
Mar;155(3):392-400.
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Insulin Resistance
in Mammalian Hibernators
Mammals that undergo
winter hibernation
prepare by dramatically
increasing food intake
and consequently, body
fat stores during the
summer and early
autumn.
FASEB Journal. 2007;21:964.2
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Insulin Resistance
in Mammalian Hibernators
Several species nearly double their body mass
in the form of fat.
FASEB Journal. 2007;21:964.2
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Insulin Resistance
in Mammalian Hibernators
The consequence
of this significant
increase in fat
mass has been
shown to be
hyperinsulinemia,
peripheral
insulin
resistance, and
elevated serum
glucose levels in
all species
investigated thus
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far.
Hibernation Disease/
Endless Summer
The diseases that we
know to correlate with
obesityhigh blood
pressure, heart disease,
diabetes, cancer, and
depressionare all
really the result of a
vestigial hibernation
instinct brought on by
too much artificial light.
Lights Out: Sleep, Sugar, and Survival (T. S. Wiley) Loc.
2041-47
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Hibernation Disease/
Endless Summer
Mammal studies concur
that once you start the
hibernation preparation
cycle, hyperlipidemia
(high cholesterol), high
blood pressure, and
insulin resistance (leading
to obesity) are normal
states that resolve
themselves with the
extended sleep that
follows in nature.
Lights Out: Sleep, Sugar, and Survival (T. S. Wiley) Loc. 204147
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Entrain Yourself
1.Entrain yourself to
the planetary
cycles of light-dark
and the seasonal
shifts to
experience better
health.
2.Live in the cyclical
tide of
cholecalciferol and
melatonin.
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