DIGESTIV

EF AVD SULFALAZINA: tulb g-i,cefalee,eritem, anemie megalo, leucopenie, agranulocitoza,

sdr. nefrotic, hepatite, neuropatie perif, urticarie, tulb pl.
EF ADV IMM SUPER : deriv Tioguanina suprima maduva hematopoetica, Mitutirixative?supresie medulara, alopecie, nefrotoxic, afect. Epit intest, Inflix- IResp super Ig A secretoare?
EF ADV IPP: Omeprazol- Hipergastrinemie secundara, H-plazia mucoasei gastrice
CLS DE LAXATIVE 1.de volum metilceluloza, plicarbophil 2. emoliente docusat, Cu/Na
3lubrefiante parafina/magnezia usta 4 iritante senna, fenolftaneina, ulei de ricin osmotice
MgSO4, citrat, polietilenglicolelectroliti=fortrans, lactuloza IndICATII MGSO4 laxativ osmotic;
CLASE DE MEDICAM IN UG, H.P. 1. antisecretorii: IPP omeprazol, lansoprazol, pentoprazol
2.blocante RH2: chimetidina, ranitidina, famotidina 3.protectoare: bismuth 4.antimicrobiene:
metronidazol, tinidazol, claritromicina
BO. INF INT :CLASE: 1. 5Aminosalicilati Sulfasalozina, Mesalazina Sulfapiridina 4g/zi in
4 prize initial 500mgx2/zi., similar Olsalazina; 2. GCz Prednison 40mg/zi;3.Imm Supres : daca nu
raspunde la GCz: deriv deTioguamina = 6Mercaptopurina 1,5mg/kg/zi; Azatiopurina 2-2,5mg/kg/zi
tipm 3-6 luni; Metotrexat 15-25mg/sapt i.m. ef bun in Bo. Crohn ; Ciclosporina 4mg/kg/zi infuzie c%
sange tot 300-400mg/ml ef in RCUH ce nu rasp la GCz; Infliximab Ig ce leaga TNFalfa pe carel neutralizeaza
EF ADV CIMETIDINA: cefalee +/- somn, fatigabilitate, greata, voma, diaree, constipatie, trpenie, ginecomastie, alopecie, impotenta, atralgie, disc-abd
Acizi biliari: colic, dezoxicolic, chemodezoxicolic. Ef litolitic. Indicatii: calculi biliari din cholesterol,
ciroza biliara, abs lipide si vit hiposolubile,creste flux biliar, scade sintza de cholesterol, creste elim
colesterolului in bila.
RESPITRATOR
EF BRDIL: Brdilatatie, stabilizare mastocitara, inhib elib LT, permeabil vasc, exudat + edem
cai aeriene, clearence mucociliar, secret mucus;
EF CO.ST: Confirmat - inhib locala: nev de corticoster sistem, simpt sau exacerb AB, nev de
brdilat 2 Adr de urgenta, crize nocturne/echivalent AB nocturn tuse, imbunatateste indicii calitate
vietii, ameteli functie pulm Posibil: cz deces, vit declin fct pulm, per de remisie sustinuta a
crizelor
EF ADV TEOFILINA: intoxicatie: gastrointestinal voma, durere abdominala, diaree,
hematemeza; c-v: TS, TSV, EV, FiA multifocala, artmie ventriculara cu instabilitate hemodinamica;
metabolice hK, hGlicemie, tulburari acido-bazice, rabdomioliza; neurologice nervozitate, tremor,
dezorientare, convulsii, moarte.
EFF ADV STAB MAST: cefalee,Gat Uscat,Iritatie,BrSpasm tranzitoriu,Tuse,RoseataTegumentara.
EF. ADV CO.ST: metabolice: intoleranta glucidica, obezitate, dislipidemie, proteoliza, inhibarea
sintezei proteice; osoase: scaderea absortiei calciului, osteoporoza, necroza avasculara de cap femural;
c-v: HTA, ATS, retentie hidrosalina; mm striata: miopatie, reducerea masei mm; oculare-cataracta,
gastrointestinale-ulcer peptic, piele-atrifie.
SCOP TRAT (TERAP) IN ASTM: combaterea crizei bronhospastice, controlul crizelor recurente,
reducerea inflamatiei bronhice si a HRB
EX BR DIL CU DUR LUNGA: Salmeterol, Formeterol
Ex BR DIL CU DUR SCURTA: Salbutarol, Terbutalin, Feuterol, Albuterol;
BR. DIALT MEC DE ACT.- bronhodilatatie, stabilizare mastocitara, inhiba eliberarea
leucotrienelor, scad permeabilitatea microvasculara, exudatul si edemul cailor aeriene, clearence-ul
mucociliar si secr. Mucusul;
EF BENEFICE STABIL MASTOCIT: suprimarea influxului celulelor inflamatorii, HRB,
bronhospasmul indus de efort sau de aerul rece;
EF. ADV BR.DIL.2: tremor, greata, voma, tahicadrdie, aritmie, HTA, hK, agitatie, nervozitate,
cefalee, roseate pieleii, slabiciune, transpiratii