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Innate lymphoid cells (ILCs) are a recently described family of lymphoid effector cells that have important
roles in immune defence and tissue remodelling. They have been categorized into three groups (ILC1s,
ILC2s and ILC3s) based on their cytokine production and transcription factor expression. These groups
have been proposed to represent innate homologues of effector T cell subsets. Unlike effector T cells,
ILCs are not activated by antigen, but respond to stress signals, microbial triggers and the cytokine milieu.
Dysregulation of ILCs can contribute to various immune pathologies and autoimmune diseases.
This poster provides a visual summary of our current understanding of the development, classification,
plasticity and functional diversity of ILCs.
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NEWS &
VIEWS
Essential reading for all scientists
In Natures News & Views section world
authorities in science explain the top papers
from their fields from astronomy to zoology.
nature.com/newsandviews
@NatureNV
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
FICKLE FATES
Physics of
asymmetric
endosomes
during asymmetric
cell fate assignation
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P olarized endosome dynamics
by spindle asymmetry during
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doi: 10.1038/nature16443
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10 December 2015 10
Vol. 528, No. 7581
METHODS
NEW LIGHT ON
CELL BIOLOGY
Optogenetics revolutionized
?neuroscience what next
PAGE 291
SUSTAINABILITY
CHARTING
THE DATA
FETAL RESEARCH
COURTING
CONTROVERSY
The real story of fetal
tissue research
PAGE 178
10 2015
10
" "Nature.
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OUTLOOK
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
Gender gap
NATURE.COM/NATURE
17 December 2015 10
Vol. 528, No. 7582
SCIENCE COMMUNICATION
CHANGE
THE WORLD
CHEMISTRY
WHITHER TOTAL
?SYNTHESIS
THE MYTH
BUSTERS
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PAGE 322
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T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
Ten
people
who
mattered
this year
PAGE 459
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DIRECTORY 2016
CHIPS WITH
EVERYTHING
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31/24 2015
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doi: 10.1038/nature16461
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doi: 10.1038/nature16459
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doi: 10.1038/nature16449
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2015 Macmillan Publishers Limited. All rights reserved
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T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
Closing in on the
long-sought
metallic atomic
state of hydrogen
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