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.



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5000 ( )W. Haak et al. Nature 522, 207211; 2015

(.)M. E. Allentoft et al. Nature 522, 167172; 2015


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.


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( .)A. P. Drozdov et al. Nature 525, 7376; 2015


40 .





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UNIV. VIRGINIA


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/ .


.
1998


.
:


.

p-value

. 2013


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18
2015

68 .
500 (B. A. Nosek

.)et al. Science 348, 1422 1425; 2015


2015

ROD SEARCEY/STANFORD ENGINEERING

.
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23



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2016


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Poster on Innate lymphoid cells

Innate lymphoid cells (ILCs) are a recently described family of lymphoid effector cells that have important
roles in immune defence and tissue remodelling. They have been categorized into three groups (ILC1s,
ILC2s and ILC3s) based on their cytokine production and transcription factor expression. These groups
have been proposed to represent innate homologues of effector T cell subsets. Unlike effector T cells,
ILCs are not activated by antigen, but respond to stress signals, microbial triggers and the cytokine milieu.
Dysregulation of ILCs can contribute to various immune pathologies and autoimmune diseases.
This poster provides a visual summary of our current understanding of the development, classification,
plasticity and functional diversity of ILCs.

Available to download free online


nature.com/posters/ilcs/

Produced with support from

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ILLUSTRATIONS BY DAVID PARKINS

2015
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47 | 2 0 1 6

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.Invisible: The Dangerous Allure of the Unseen
p.ball@btinternet.com :

1. Fukaya, K. et al. Org. Lett. 17, 25702573,


25742577 (2015).
2. Zou, Y. et al. J. Am. Chem. Soc. 137, 70957098
(2015).
3. Parr, B. T., Economou, C. & Herzon, S. B. Nature
525, 507510 (2015).
4. OConnor, M. (ed.) Pointers & Pathways in
Research 41 (CIBA of India, 1963).
& 5. Nicolaou, K. C., Vourloumis, D., Winssinger, N.
Baran, P. S. Angew. Chem. Int. Edn 39, 44122
(2000).
6. Whitesides, G. M. Angew. Chem. Int. Edn 54,
31963209 (2015).
7. Kleiner R. E., Dumelin, C. E. & Liu, D. R. Chem.
Soc. Rev. 40, 57075717 (2011).
8. Kanan, M. W., Rozenman, M. M., Sakurai, K., Snyder,
T. M & Liu, D. R. Nature 431, 545549 (2004).
9. Li, J. et al. Science 347, 12211226 (2015).
10. Gillis, E. P. & Burke, M. D. J. Am. Chem. Soc. 129,
67166717 (2008).
:
go.nature.com/xrsdms

JESSICA SCRANTON

. .. .
.




| 48

| 2016




2
.1

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.PubMed Central

.





.9



.


.
.

. .


.
.

.
mmckinnon@conservation.org :

1. Fisher, B. et al. Conserv. Biol. 28, 880882
(2014).
2. Doemeland, D. & Trevino, J. Which World Bank
Reports are Widely Read? (World Bank, 2014).
& 3. Snilstveit, B., Vojtkova, M., Bhavsar, A.
Gaarder,M. Evidence Gap Maps: A Tool for
Promoting Evidence-Informed Policy and
Prioritizing Future Research (World Bank, 2013).
4. Gilbert, R., Salanti, G., Harden, M. & See, S. Int. J.
Epidemiol. 34, 874887 (2005).
5. Rijsberman, F. & Zwane, A. P. Water & Sanitation
(Copenhagen Consensus, 2012).
6. Pullin, A. S. et al. Environ. Evid. 2, 19 (2013).
7. Collaboration for Environmental Evidence.
Guidelines for Systematic Review and Evidence
Synthesis in Environmental Management Version
4.2 (Environmental Evidence, 2013).
8. Bottrill, M. et al. Environ. Evid. 3, 16 (2014).
9. Lu, Y., Nakicenovic, N., Visbeck, M. & Stevance,
A.S. Nature 520, 432433 (2015).


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)528, 2021; 2015



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(go.nature.com/clylrn :
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274
2014


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)Q. Li et al. China Econ. Review 36,
367376 )2015(; G. Ding and Y.
Bao J. Child Psychol. Psychiatr. 55,
(.)411412 )2014




.


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wanglong@csu.edu.cn









(W.-W. Li et al. Nature 528, :
)2931; 2015




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.)478, 2931; 2011






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(
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)551; 2015




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(J. E. Gilda et al. PLoS ONE 10, :
)e0135392; 2015





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.


.
mlandry@avivasysbio.com
|

57 | 2 0 1 6


)(20151929

| 58

| 2016

1969


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.1972



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.Research Fortnight

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.Unmaking of the Modern World
ehsan.masood@researchresearch. :
com
@ehsanmasood :

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KEYSTONE PICTURES USA/ALAMY STOCK PHOTO

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.
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? We Going 2000

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.1972
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.1975

:


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20


.
e-mail: p.gandhi@soton.ac.uk
1. Bowyer, S, Byram, E. T., Chubb, T. A. & Friedman, H.
Science 147, 394398 (1965).
2. Webster, B. L. & Murdin, P. Nature 235, 37 (1972).
)3. Kimura, M. et al. Nature 529, 5458 (2015
4. Fender, R. P. & Belloni, T. Annu. Rev. Astron.
Astrophys. 42, 317 (2004).
5. Casares, J., Charles, P. A. & Naylor, T. Nature 355,
614617 (1992).
6. Khargharia, J., Froning, C. S. & Robinson, E. L.
Astrophys. J. 716, 1105 (2010).
7. Miller-Jones, J. C. A. et al. Astrophys. J. 706, L230
L234 (2009).
| 60

| 2016

| 1 .


.

250 ( 1 .)1

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.
..



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..



"-" .

.6
..




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.


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.



04103.

roger.glaeser@uni-leipzig.de :


1. van Veen, J. A. R., Minderhoud, J. K., Huve, L. G.
& Stork, W. H. J. in Handbook of Heterogeneous
Catalysis Vol. 6 (eds Ertl, G., Knzinger, H.,
Weitkamp, J. & Schth, F.) 27782808 (Wiley-VCH,
2008).
2. Zeevi, J. et al. Nature 528, 245248 (2015).
3. Weisz, P. B. Adv. Catal. 13, 137190 (1962).
4. Martens, J. A. et al. Angew. Chem. Int. Edn 34,
25282530 (1995).
5. Garcia-Martinez, J. & Li, K. (eds) Mesoporous
Zeolites (Wiley-VCH, 2015).
6. Krger, J., Ruthven, D. M. & Theodorou, D. N.
Diffusion in Nanoporous Materials Vol. 2, 807837
(Wiley-VCH, 2012).



. 1
2


2015 Macmillan Publishers Limited. All rights reserved

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79104.
tobias.schaetz@physik.uni- :

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1. Tan, T. R. et al. Nature 528, 380383 (2015).
2. Ballance, C. J. et al. Nature 528, 384386 (2015).
3. Einstein, A., Podolsky, B. & Rosen, N. Phys. Rev. A
47, 777780 (1935).
4. Aspect, A., Grangier, P. & Roger, G. Phys. Rev. Lett.
49, 9194 (1982).
5. Rowe, M. A. et al. Nature 409, 791794 (2001).
6. Hensen, B. et al. Nature 526, 682686 (2015).



Arabidopsis
.
.



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.1






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2015 Macmillan Publishers Limited. All rights reserved

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Arabidopsis

.





.. phytobiome


.

.

3211-50014 .
gbeattie@iastate.edu :

1. Dubilier, N., McFall-Ngai, M. & Zhao, L. Nature 526,
631634 (2015).
2. Alivisatos, A. P. et al. Science 350, 507508 (2015).
3. Bai, Y. et al. Nature 528, 364369 (2015).
4. Bulgarelli, D. et al. Nature 488, 9195 (2012).
5. Lundberg, D. S. et al. Nature 488, 8690 (2012).
6. Schlaeppi, K., Dombrowski, N., Oter, R. G.,
vanThemaat, E. V. L. & Schulze-Lefert, P. Proc. Natl
Acad. Sci. USA 111, 585592 (2014).
7. Edwards, J. et al. Proc. Natl Acad. Sci. USA 112,
E911E920 (2015).
8. Horton, M. W. et al. Nature Commun. 5, 5320 (2014).
9. Rapp, M. S. & Giovannoni, S. J. Annu. Rev.
Microbiol. 57, 369394 (2003).
|

63 | 2 0 1 6


NASA/NOAA

2015


" " .


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| 64

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.Science 348, 340343 )2015( :


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. ..
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.Nature 525, 251255 )2015( :

2015 Macmillan Publishers Limited. All rights reserved

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()Nature 517, 150152; 2015

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.Nature 517, 187190 )2015( :

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.Nature 526, 207211 )2015( :


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.

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2015 Macmillan Publishers Limited. All rights reserved

65 | 2 0 1 6


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carmen.cepeda@imdea.org; :

teresa.perez.prado@imdea.org

5. Nie, J.-F. Metallurg. Mater. Trans. A 43, 38913939


(2012).
6. Sillekens, W. et al. Metallurg. Mater. Trans. A 45,
33493361 (2014).
7. Ferguson, J. B., Sheykh-Jaberi, F., Kim, C.-S.,
Rohatgi, P. K. & Cho, K. Mater. Sci. Eng. A 558,
193204 (2012).

1. Chen, L.-Y. et al. Nature 528, 539543 (2015).


2. Mang, T., Bobzin, K. & Bartels, T. Industrial Tribology
(Wiley-VCH, 2011).
3. Helms, H. & Lambrecht, U. Int. J. Life Cycle Assess.
12 (spec. issue), 5864 (2007).
4. Deschamps, A. & Brechet, Y. Acta Mater. 47,
)293305 (1998


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.
.

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. ..

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.

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30322
.
1. Long, J. S. et al. Nature 529, 101104 (2015).
2. Subbarao, E. K., London, W. & Murphy, B. R. J. Virol.
67, 17611764 (1993).
3. de Jong, M. D. et al. Nature Med. 12, 12031207
(2006).
4. Danzy, S. et al. J. Virol. 88, 1343613446 (2014).
5. Steel, J., Lowen, A. C., Mubareka, S. & Palese, P.
PLoS Pathog. 5, e1000252 (2009).
6. Munster, V. J. et al. J. Infect. Dis. 196, 258265
(2007).
7. Hatta, M., Gao, P., Halfmann, P. & Kawaoka, Y.
Science 293, 18401842 (2001).
8. Linster, M. et al. Cell 157, 329339 (2014).
9. Mehle, A. & Doudna, J. A. Cell Host Microbe 4,
111122 (2008).
10. Gabriel, G., Herwig, A. & Klenk, H. D. PLoS Pathog. 4,
e11 (2008).
11. Paterson, D., te Velthuis, A. J., Vreede, F. T. & Fodor, E.
J. Virol. 88, 339344 (2014).
12. Weber, M. et al. Cell Host Microbe 17, 309319
(2015).
13. Rameix-Welti, M. A., Tomoiu, A., Dos Santos Afonso,
E., van der Werf, S. & Naffakh, N. J. Virol. 83,
13201331 (2009).
14. Mnz, B., Brunotte, L., Reuther, P. & Schwemmle, M.
Nature Commun. 3, 802 (2012).
15. Moncorg, O., Mura, M. & Barclay, W. S. J. Virol. 84,
99789986 (2010).
16. Shinya, K. et al. J. Virol. 83, 1301513018
(2009).

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gonzalez@irbbarcelona.org :
1. Knoblich, J. A. Nature Rev. Mol. Cell Biol. 2, 1120
(2001).
& 2. Coumailleau, F., Frthauer, M., Knoblich, J. A.
Gonzlez-Gaitn, M. Nature 458, 10511055 (2009).
3. Derivery, E. et al. Nature 528, 280285 (2015).
4. Hoepfner, S. et al. Cell 121, 437450 (2005).
5. Goodwin, S. S. & Vale, R. D. Cell 143, 263274 (2010).
|

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Physics of
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L Nguyen et al
doi: 10.1038/nature15742
OUTLOOK

T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

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to both male and female needs
in Atlantic salmon PAGE 405

Gender gap

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WHITHER TOTAL
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THE MYTH
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PAGE 327

PAGE 322

A nugget of truth is all it


takes to sustain false beliefs

17 2015

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| 74

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A20

Prostate
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The big, the beautiful


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doi: 10.1038/nature16062


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N Denkov et al
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2015 Macmillan Publishers Limited. All rights reserved





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A Orthwein et al
doi: 10.1038/nature16142

T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

Ten
people
who
mattered
this year
PAGE 459

ONE YEAR. TEN STORIES.


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PAGES 483 & 534

The Nature guide to global


science events and courses

A system-on-a-chip
microprocessor

GENE EDITING

CRAZY FOR
CRISPR

Tales from a pioneer


of the technology
PAGE 469

31/24 2015

31/24
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T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

Closing in on the
long-sought
metallic atomic
state of hydrogen
PAGE 63

PRESSURE POINT
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A new resource for the scientific community


Natures section devoted to reporting scientific software, apps, and
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most commonly-used software, and articles about online research
including open data, citizen science and crowd-funding.

Visit Toolbox online: nature.com/toolbox

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Immunomodulatory Drugs

Immunomodulatory drugs (IMiDs), including thalidomide and its derivatives lenalidomide


and pomalidomide, are currently used to treat multiple myeloma and other types of cancer.
Lenalidomide is also effective in the treatment of myelodysplastic syndrome. The molecular
bases for the clinical effects of IMiDs have been uncovered in a series of landmark research
articles, which are presented in this collection along with related reviews and commentaries
from Nature journals.

ACCESS THE COLLECTION FOR FREE ONLINE


www.nature.com/nsmb/collections/immunomodulatory

Produced with support from

2015 Macmillan Publishers Limited. All rights reserved


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2015 Macmillan Publishers Limited. All rights reserved

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