TOPSCIEDIT

EDITING TEST

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INSTRUCTIONS: USE TRACK CHANGES AND

WRITE COMMENTS (ON THE SIDE-BAR) ABOUT
QUESTIONS, ADVICES AND WHY CHANGES
WERE MADE TO CLIENT.

An early diagnosis is critical for the successful treatment of many types of cancer.
Aberrant DNA methylation in cancer is observed in early cancer development. In
addition, identification of cancer specific epigenetic changes has promise in
molecular classification and disease stratification. The methylation profile can
distinguish tumor types and subtypes and perhaps the response to chemotherapeutic
agent and survival. We have devised the Cancer Grade Predictor (CGPredictor)

algorithm and package functions to facilitate the systematically integrative analysis

through high-throughput DNA methylation from best self-similarity subgroup patients
with regarded to survival outcome. CGPredictor is the first integrated analysis tool for
extracting and examining the identity predictor supported by various validating
examinations with regard to clinical outcome. CGPredictor could utilize well devised
or specific clustering genes to cluster out the strong self-similarity patients. Then,
according to the methylation and gene expression intensity between the distinct
phenotypes, the gene panel could be extracted out from the devised functions in
CGPredictor. Moreover, the most important functions for the CGPredictor are the
statistical significance examinations for the gene panel and the association between
any specific or well-established clustering genes and the distinct phenotypes. Both
statistical significance examinations were comparing with the random selected large
iterations through DNA methylation status. The experiments implemented on highgrade serous ovarian cancer (HGSOC) and breast invasive carcinoma (BRCA) were
taking for demonstrating. The results obtained from CGPredictor not only assessed
the significance of the gene panels and association between the clustering genes
and the phenotypes but also some of the markers in the extracted gene panel have
been significantly reported in previously.

2 Editing Test
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