Name of Examination: Activated Thromboplastin Time

Definition:
The APTT is more sensitive in detecting clotting factor defects than PTT, because
the activator added in vitro shortens the clotting time. By shortening the clotting
time, minor clotting defects are detected. The APTT is similar to the PTT, except
that the thromboplastin reagent used in the APTT test contains an activator (kaolin,
celite, or ellagic acid) for identification of deficient factors. This test is commonly
used to monitor heparin therapy.
Preparation:
1. Wrap an elastic band around your upper arm to stop the flow of blood. This

makes the veins below the band larger so it is easier to put a needle into the
vein.
2. Clean the needle site with alcohol.
3. Put the needle into the vein. More than one needle stick may be needed.
4. Attach a tube to the needle to fill it with blood.
5. Remove the band from your arm when enough blood is collected.
6. Put a gauze pad or cotton ball over the needle site as the needle is removed.
7. Put pressure to the site and then a bandage.

Purpose:

Find a cause for abnormal bleeding or bruising.

Check for low levels of blood clotting factors. The lack of some clotting factors
can cause bleeding disorders such as hemophilia, which is passed in families
(inherited).
DATE AND TIME OF SAMPLE COLLECTED: August 28, 2014 | 6:58 PM
Name of
Examination

Result

Normal
Values

aPTT

41.8
sec

24-35
sec

% Control

33.5%

26-37%

Significance of Abnormal Results

Prolonged.
When a tissue is injured, the extrinsic
pathway is activated by the release of
thromboplastin and the clotting factors
are responsible for a series of
reactions to form thrombin from
prothrombin. A prolonged aPTT result
may be due from a decrease in
circulating clotting factors.

Within normal limits