Oral squamous cell carcinoma is the sixth cancer in the world (Weinberger,

2006). Pathologic Anatomy Laboratories in Hospital record from 5 areas in Jakarta

shows the 14% from 3023 cases, which is 434 are oral squamous cell carcinoma.
The major location is tongue (21.18%) where 52.07% are Oral squamous cell
carcinoma (Setyawati, 1995). In Medan from 1015 oral lesions, 674 are neoplasm
cases (66.40%), oral malignancies are 313 cases (90,46%) which is oral squamous
cell carcinoma (Octavia 2002). Based on Pathologic Anatomy specimens in
Tasikmalaya Hospital founds 15 cases oral cancer from 3.943 cases in 2 years the
most cases are squamous cell carcinoma (98%), the major organ is tongue (46.66%)
(Darjan, 2007).
The process of oral squamous cell carcinoma is multistage and multifactorial,
as changing gene accumulation due to environment, inflammation and virus (Choi &
Myer, 2008) also acid folic diet (Uthus, 2006; Davis, 2003). Based on data of
COSMIC (catalog of somatic mutation in cancer), Cui (2007) managed to make
human signaling network that integrates 1634 genes with 5089 pathways that have
a relationship to one another in the mechanism of cancer, both genetic and
epigenetic