Notes on Hypothalamus

1) Anterior hypothalamus lesions cause insomnia because the

suprachiasmatic nucleus regulates circadian rhythm and the
ventral lateral per-optic nucleus inhibits arousal systems (note
here that the histaminergic, serotinergic and adrenergic
systems are arousing systems, thats why anti-histamines and
SSRIs and SNRIs are sedating)
2) Posterior lateral hypothalamus lesions cause hypersomnia
because oretin/hypocretin neurons stimulate BS nuclei for
arousal and thereby regulate REM sleep. Since it causes
arousal, therefore Belsomra or suvorexant which is an orexin
blocker can help treat insomnia
3) Lat lesion become thin
4) Medial lesion become fat