cerns camptinateler. Conpimsele se conserrear} In aml nen inoe wet dec ete neoieT oerec, et eainh. Conti 9 [CAPSULE GELATINOASE (Capsule pelatinose) Covell gelatine presnt nvelut de gelatin cae sevese pent Desesaroass prin iahiie secs, Fc oti ns in Cale en mat rtspnate pena admiistaree medcamentle fe eale call. ‘Ge! eetcitrtinal cape se csi pun tm bette cng I> {eu Ge poland poate cone plstin} ner agent tenstncti, co even sont lament Actulmente deen de stomenes #!cpsle eve, vapnle ‘spre dewoie de dae comprmata tn capa ubelana sid ycts! sit nt eaglomeral cera ce petaitepuneren In iberate 9 ‘Sonu: edit dpe daavares na mera inv ‘Scop nj a ude caper a fest mascare gust nepicut ‘ourre aman Astsperalesd opin cl odspenates ed amon su frmd de capsule ete supercar ceoiaepreparte soe fa cx en. Carell prninth areal met dene ene seoanh orepuatior oposite apres de amiistare. ‘ascares caper gelaincase pote fSeuth dup dues pore {lr Secisting dub supe: capsule gelatine ease sau net 9 capsule innoue ew eapa seu operate ‘arms capslelor gelation este peesntt In i186, Capel gla cae me to form eri, eral slung sau cdi pa ni eee, agate de pnt Ia 1S, cu sn rk Ibn. le pot Incase strane medcamentat cide sa ub Lom depth. Cap Ine cu caacates 0,-0.2 ca seu uetoae sia suite unest pee Irerla eatineee Sa ele cu shunt ~ tatine fbetnge) in are ete ‘er expuza conn ind capt si destinate penta caps 1m ancl de modal de pupae, capsunie geatinowe pt ete cepa otinse pin sufundare (mere, eapsle plana: apse ute pei lear. aneotutaulonstle cna 65-1000 comprinte pe minut. Ds ‘ie resets decal st mel mare de 12 tlipce 4 Shales ve! Ge automate se desebye de rim prin Tap cd soning ‘loon peste namtrres amb. Automata de tial Al~AL (ug 155 aneponeah In modu! wd. Conprnstle dn buna rare wags sw dapety ox ital cae araneah const ‘dou adr ln nut neta! pe Dnde declan neriar. De ‘le de cetan se sear, ats ale In ambalje cu un arunit aun ‘omprinate Ait able contr de fap ct amballe Bd coat ‘Sigurd octanjeae comet.Fe 1 Fete pn 19.1, SCURT PARCURS IV ISTORIA DEZVOLTARI CAFSULELOR Consula ine din Intneye, Caps, cect ce iseanat “eli, ‘mentrant” Iocorpearea medicament fe Ineliydemult fens {isan rinse informa tn acest domenis daar din 1839, Acct aft ‘en frmaiplr Motes Dube in Pr, cate a flat eto mld pentru peperaes capsllrgolstinowe me prin suture let dene, ane x mar ae aise oma cl, se I sent nme akc «es tng et 1 187i» SUA, Habel a consi un automat pena prepare: eo en metoda imei! pent pina da a fn prepare capa ‘anu enorme, ‘1933 a fot desis rma usne de Iicre a capella © ate dese fst cord capsule nan S,cnd aft. xoecte inode pe ag tn medicink antibiotic cu miter epi ‘est ama, Prepare industrial a eapullrIn acetal e ereut {os ma aes nS... Angi, pons, Germania pe Jew x pep ean poset Acroimenis produce Intmajonlf«cajnueo a ume Sebi Banos, dup dale ime! sues “Capra, anual kn Tame ‘repack pete 60 mle cape, dn eae mal mult de 20 milade ‘elo mol Noma fms "Lene in Ang near anal peste 20. ca “ ue genome mo, mt mult de 60 denumit, wins “Slough” din SUA. — Pnsierde csomle gaioone ta Ta SUA. sellin Inder care edt oraciochUnreaeh Im capale glint! urmdtoace ‘Secins, ampcting, lami, ratiy ibslsina, amps ante fe co wlanine ee tn cpmle guatnose mol se produ wimlloaele prepare: seat de i, linen, exact erigh amine A HE Poses prepare glass oosete Indore mate en ce can fe colagen,Acetes st omele,Hpamentele, cree islor mac oenute finilnde pore. Vast animale webu opti: 15 an! pnt pr, Eel penta torneo misea vit! animsilrandamentu ssates iempeata de pce uae vs meprent ‘dependent de meted preluccl mae prine ve desebesc coud sevode do prepare a geltines axieS a8. Gelatnn prec pein tind ell x pnctl nol ap 3 se mmc tip A. Galati ob {stk pimn meta tac a mae ee ete cunceca a up Bx punctl elect pH 47-8. Mat gnc eltne bac. Honda bench de repre ice nul capes etapa cone etapa denaturi rctelaco In pine cap ‘une pi ragmentath ce cone clagen se cenujrejte multe ale ~ ‘rin pretcae ea sla de eau hlroxid petra separaen grim, =o Ieinelor tla, mlopazahardlr. Matra pint ce conine calagen Se iene, are lo Mdrotzn guplor amide de clagea,fenind amonis Aescompunerca harlteh«ealagenlat~ deca infer ea rraat a ‘dscempunei pri lets plipetge ale clagenuii tlle mi Tm etapa dou rman cep se salt co 298, ve alas nv flere in temperatura 60-95 Are Ise dentuaren protec, Car fe nso de rperea igure de ogen. Penta eva deacon secs nl edoch« eoeersed ble Peete inne ene ‘eur de irere nu abu epdgesse 95°C, ‘aaa de gelatin eres, se cancenuear In apartle sub wid 20 "eee uel, Gelaina ural (amidstes nu mai mate de 165) secele fi mat ena oan ae crt 1 ccirhcyet i mt 2 es on ac tp oa SS mines otis Bee's; anes emegenia puter Sele os mal Bie: Sn) ge mpokiiee f= ler repent meas frase rect. Derren cide tie ste tnpal ndehngn de oa ‘erie doles putenich colagenu pink Ia prose mit (lee mires cline satin, inde pretucreard cu ace iv fico 8 rurgeccce mat Tat maui exe i dae pide 2 Ce a cenuive ac a oe are stimula fares clagenal (argc, decraren Ter ete) Ase, pen metodn acl materi em (ck cenupicen Cote spud une acu de rath dural alot minerah pin {atatsatror ce hoish eee Ia 60-90, Meta et mal ‘elatna est cu un gel ma wae vce ma nl, ast cre il te ere mic ta func de materia en eto de face, pofitiilefcochimie mecanice ale gelatine se hinbE. ‘Moectl exterie gelation reqesit nie pS su ane Insare a fiat, rive 8 gpm, ‘Gelatna ete un press i colagenumrotza paral ~ su ‘arg rapna nar, prea inipal sul cates Ia basa melee potent» gelatine! ete alee papel, 193. FREPARAREA CAPSULELOR PRIN ERSIE ote um graced nce operas realizar ts pat stadt de nc prepares mace! guatincae,ebiteren capsule, umplecen exile; ‘Piuicce comet Se luceast muna sa somiasonst, falosod Tome orc majotate lemurs cnstute din gelatin, crn. ap Cant ot vrai fonefe de propettie fcochunie ale gl heats de vistas slo Deagurc& propor de eatin escent jd for, ines a les ghtten pert cap {Siete formule reas presets unt conser colorant ‘4 dn enna pl de ene cn, poten, ene (om cae, Anne a ep gt po Cc meccient ela poe eae << tut total cel ami, hidroxiproin, proline gina. Continatal Md ; eee ma Bs seer ale peep ce os ee {ieee voces he kA at Sond eal ar = = = Sone oe crepe se ree ese ca = = 2 fempeatta de ape, deszemenee popetaten gelatin de 8 210% in tuigeste. De mengonat ch snes, sre dened tone step, depnde de masa molecular gratis. Confit cee ele eatin ranearea atk dt sponges ‘a prepare capuleose ao mae ata at gelatine Proce ete za pe wenBlssle oer (1571) prepares mse esatnone, 2) prepare preplor apulietdscise la un ap 3) ump ‘e copines #) sudan, S) sone ep 6) wena cabeller “asravenpaplare: 8) segenerares case sebute ‘reperrce met uainoae Se Grr () ate ingredient conform ‘uy, piul, mitines pacer de ela, wanaparejs, sua csi tea esc ines(2) Ize! cu chat de a8, reuse ‘Somat a emperta, malaxtancort cu alte, = intodue apa ‘iets "Tempeara seen oe ace Ia 70-75, daugh canate Joueojertcalsares cpl calle cle ma nie int coset ‘elt de conserant (iagin nae e cv punlné Ye func fn eet es piney cre Sede ‘ior Tempore ape see le E28, so dangh gelatin foe cena se chimb§ stubitren auane lor pYocotaten goal {ele reduttoure tebule sitlniate, decrec rearjonear cu sean ostdl ~ pach H a 1. tne rrp bet sec connutl eater nt in aren complet glatine. Mass ‘Shmust on mengine la tomperatre SW tmp de 2 ore, amesecne caus : (Gnd bern termina, entra tur ser names, are tor se anete 0 pomp umd (3). Asp se fects mal In Ine, ‘Shocdnd jt reaping vent Goines nia cud penta 8 excade [Posie pum muse, ir in ltielecee minut, oben x id je decide complet tliturresaerul a mast te loc 15-20 min aba Milo nterage Bs recor se drama la er Ail mae oe Ink pe feu! reactorult Mas gins ans nun temo speci (8) 20 tt pene stabiizare 28 de ore la 4°. nell nett al maze. Srplarl se soge in alt terme cae up ce ‘nee termesate bin Pentru imesare gat iseseae cu chm de fictive seco, unde temperatura USC) se menine automat ‘vorl emeregltoraia ‘ec eapulelor gelatinase se formest ce ajtrul rato fnme de Imrie. Fomele repesnt nite (uj! in dualumiin de format oral (Caine 2 mm, lamer 10m), aipe orm tn mumke de 28 buck ndtny 0m un elt Tmt de marie ama cy otmele fen ge 5-6 mi Ia emer ‘ace de 3-8. Rams ct nah In pean cu un sat wb de ue de eset sesclundtncet in aia de imei yp ca masa cal po ent Se soa se asf se surg urls mas 9 nore cu oem a, Sin nou ie itodue herent psnzare tin de ID-1S min. (om ‘onitent ramelee mie pe anger). Tadlinee told &taiqurir ox tzu gt ou tebe ak depend 26-28 mm In tmpal gelatin nell ere cca 15-23% ap8, devine asi: Gries ase Iveljla Sefpd de temperatura de ere, ‘ecotten mas! gelainos, temperate ce gelatine. M ‘ull tebe aft bn ile 085-00, grninen teil crud = 8570/6. Rama ls conte in ry, velpre 2 scot marl (7), 5 ct pe otal de alumina are 2b. nd we ot de pe frm,Anrep co pings se rebate, cle cu ble de ae de fate eles veil rebate weep cenfugh seca eta reasereen deal departs nvr seat pe abl We Ia tee). ‘Unpleres caper. Operas face prin fete posed, dente nare ae agente o mabtane tine fe mom de sepa “cprlele goles smjnk pe spat speciale coi Il wind as sco ve floret un daar electrons popu de VA lest dvd enter cu eit cent oreparte ns Dorsal Invert fbn de casa ae In extemal pete pe linpere cepl gelatinase mea ec In satare (poduciaten ‘alec lol orto ~SI00 ape et). ‘Sharen capo. Aceasth opera eee diet pe suport (i nde at fete capuele co autor cocanalas deci de ht Fl ‘eta i a 55-65, cocanul manual erty I jor sfc 1S terol: Hee ter cde ec gil cage Caletet pind de vempeatra cca, vcortaten mae! gelatinase, det (ara de gelatisare a neti Canola apelele Caudle gelatine mol webue sf ee rein teansparent, nu tebe sb tle de ner su impurich m Techderen Weble oe ated, runs, sbsanele dzate exact. Se ‘anal erelle sere (nde slain Soul x pre de Hh grime, cu bale fimpurd mecanice. Cape cu defect se tare sete la regenerae (6). Cale cata se age ntean stat Pe ‘een, operat cu perpen se eel uscre ‘Uncaoacanmllr Se letasS etre (10) cu un caren e ei lar frat a temperatura 23-20°C np de 20 oe (uraiatea aera Tit de 66). Cu ery were lore np seth i nd Entel cat conie 10-12% uma. Capra devine oa tear cafelledefomate mutes, cre cag. Ele de aemencs cule tte species nde in epeerre (10). intron carvan: Openia faseoSopa de a fine capa ‘apaafa oat betedd jl ods un spect exter crespunaior entra acura caps wate verison de pe een ister (1) ise amet caus od una de lta, supealas lr devine neta ind [nin terminal, canning In are species ea spa. Sparen cape, Splat s face cu Scpul lure lta p= “or pun meeanic de pe supa afl. Perr acearacaprlele 2a I vas (12) se odaugh teoretend sau ace! teoprpie, se ‘coped tse amet tiny de $710 min. Apol capsule se descr pe a8, {= voecui et sees pe He jematl ca ergament le uc ‘eS (0, Useares a ous wmf sap entra res Sevens suai din neil casa timp de oe, cand pin etd ero fenperatura 23-26 pumidne relat de cca 695. Dupd axa ape Inc conoleas dit nouvel rebut Intonrce ln epeerare (1) it ‘i caittve~ Ia elt Capsuee se ets cu cpus lor Ta vas (0 Pente asa tard Wcoreent en ll nore p23 min. 9 ‘svete, Aol case cutte se sound pe refele,aerte x Peat nen eal fae ark in en (0) Uses tein wrote trae ‘Sretullfatiagees UB Howe Tava de ces 10K. Procera ‘Scice dnp de sera omperatura 20-22 puma ead sel ‘5 ma ml de 6S. Capeuee wea se ambalesr8 I eipente oa cath a um fest Reganerarea capa. Capslle cu defect, separate la dete sad tehoolope fle slain pepuatll se separh de Inve capsule ‘i cent (16) Slain se analiza up aren na ‘Thar preduci ena umpires eapallr) aul iterate de peprt, spall minus cu werent ve (09, sacar tn eatn (1) destin penta regnerarea mas ton ‘8 caletnd ca confit ef al #8 fe 6% Confnutd uni Ia Tove dup sparen orca toretiead alti 15-18. 1m ear ses se topes mete inks ane 0 mal ome ssn se ait exo pomp cu vid (3) ind masa pra, mab de ca (ea pope ncochimice se mace (5) se flee la preperres ‘soso gol Mas regenera de oie floes in pedo apart, stones aces ntpls 19.4. PREPARAREA PRUN PRESARE (STANAKE) Cepmlle eelanoae pot pepaate i pin ictuderen subvani Insiameatose te dou lide gelatin, care apo sat supe pres(PST te nei Ket sccm Boel e989 7 khan pee om ine Fini ft labo 196 de Laval Theva, cr flnen un Dosis Ferma in out plc metalic, ain pre emserce. se execute In indus caper wnt ind! Pca ap. Fela {atin se petuceac pe o plck de metal Inet pe care 2 ges ‘eespunsttare ume de came. Foun de pln i forme {pref contnuae ve induce fm flecae mae e capall eel ‘mall sbsanja medicament deri ae et de obi eh. im indo umpires ae face cu pomp doctere:Dupt moet prune plat se aplcd «dows plac, cre ete newt cx pina 4 xe {up acl md x oon de gland i155) (ele Gut plc se peseart cu 0 pres lrouc ate se f aovuele Maple pefecinat po ange un randameat de 6000 ca hecll sbtn pn ree tered ls agatha est cele prepare in mee. Ce a es product strc, den fie pele Mal arse abi pein acesrth mead cape veiled ar leecaronrs Peveleejnute pn ce proced ot recunscute pin peesenfa une nw metene scutes repent cl de wudare ea atl le ‘pte mal pe mnt 2 1 neiicare a ode des amir fs relat tn 1933 de “Schreibce nft ct ew ela su vault, ele dou tai sear de tien cpellr cote sen inves. fe Tarts inno To er veal oak bers de pln in care eel Sel dou jm le cps: sutn care cost confi fl oe de asia att Twig IS? ee pemmlt schema ancien unt magn ca mate roe te penile capil ellison. Valfrdeat got aeu ch ene fame: sec, cole, ngs. Saul fare vise, suspense {car plate pot nota tc se dapat ssteme de mpl ae ‘vane acest ocedeu cont apa cb amplerescasuelot ete compet js ace mefeedia aid pat ob {iat pin clraren relrde gelatin Maye de act tip sing © Po. icant de 10000 ps per,‘ mopinh cu randamente mat ete popu de fe * fete ge gland sot apse ca wid omelet pe il ‘cst od a pot tmp susan pulvereate cu un randament (G00 capa pee Maina Aceogel ar clint separa um cingrs e ‘eat een ete, Poa! Ge ha a + Doul tent de gland ainentar cindrulat ea de ‘nde ce sotrl radu ve frmeash dud junit cape, ‘meicemeniouh et teat cla ensure lapel out jr capsule, cre se suptpun, sat sudte ana {ern dn mapin cases tate eae genes Itecie)paepuse wet ‘La Una ChimioFurmaceveh din Gok! funeyonesd ¢ nie sutomatzalS (ira "Leiner", Angi, care permite fabian ‘lr de casule mot pn prese. roceltehndop de faba 8 lor eat seat din untae opera eeprres tes, arava mesleanensoe pens umplre (leur, st laos, fe, pepuaten capsule gelsinowe (tunaea, umblees, ‘llr pwseareseapller; contol pf ambulres eau: ‘eget 1 Sana ee ian i ne ~ tn Spins actmncea) nectar ‘a ed Acs roceien permite ples capo chide scr ll cnt fap chopra dumper efrare 9c in cence Pntran th ne, la Redan Wee sh soe nap ice a lic Crowded dearer pelt ca itn med de pee Scone uc de pind Mien came pte moti ‘ots wits de sigs iit medicament Aces poeten ‘lit n mae Globe, cr su un abdomen e000 cpl tie 160. a sin pct de wate fc su Cite peel cable, Cane Sudo pes loss Nietoda pleut condigonearh © date exacth » medicament, © rolucre penis folntenecnom de eatin, ‘hin acath melo ecomod de incapsulat amine A E 9 K slbie etm Cane obit se se desebte ur nis net med 16. CAPSULELE GELATINOASE TAR ons ee pega ee a Sere ee ingcave se Iceporarh medicamentle Capella rin nee, a procera! latices lr decuge oem int foarte fag ind se cot de pe forme 2c (ind, de ace Sule tate te In ana umecat cu vapor tempera “hates 7-895), Dap umectare capsules cl wf de ef ove cind we arlene igurs fotda ete Cops unite gata seule cut ace 10 baci Coplle operate se produc de 8 numere,cae se -apsoiten nei, vind urmblwrele craters ‘Copulelesetnchid ps ebberear da magi recipient. Apo caput ‘pals mapn, unde cual supe de eloipele subtalar oentowe is lanre| 197. UMPLEREA CAPSULELOR ents umpires capsule opecuate se fos automa tec me, arse deste dup producti (e120 pila fhe pe el) pt dophexacttsten doris (25). a unep de ‘urgeeasutetangel mediamentoaesomatle ot cu dzateae ernie cu ling, cu su cu tae. fn auomatl lene M Inentace pt etentare, care are 20 tuburtalimentafoare, qeza {at Case orientate (andl je capa) eens Unplre,unde e ajtora ill se dex, mpl cu nena 0 och ae Ince, apo ar supa Ssunjsiee metcanentne f= jefe Scheme umpc Ta dependen(t de ena x consactia tomate de tuncije de proptie lcechimic le suanjee ter raul, moran, mieten, mirocomprinat, Ps 198. PROTECTIA $1 ACOPERIREA CAPSULELOR Capsule enerertente ot ladle (cpulaegeldurate, capsule ses ecb de cele peltinowse rn ace, hele sin preluctte ole alot de cemalind rt vapor Se frmadsh Aste gltine Tn gutn pled peepee eevee 98 na, disvnd nce bate. Aja cpl rec somaca Bk ito hinders esareg in coin Satie intestinal (cagele “inetinale') Melurates capella pete ist meus, pe fd cua se pune oust de alse ole inal de orale in apr sl dese a1 de ch essa. Copuee ested be un di de preln apterous fon{ols flier de aspece "ai de ace. Cu acest sop cause gence dt epeluresz ca (i de 5 de acto de calularh nascar aol 2 naughacettlatal in mas eltinoash seidalsteaiplnacett, mnoglceie acetate ‘Conte cal. Se cletua:4conoem onogeel arm eapele int FS XL vl. pe, Determinare masel Medi. Se dntree impr 20 de cape se determing mass mee» casa. Apa se tre care cape {ise conpark cu masa edie opel Variaile mal ear opel {rebse sk dep earch #105 eases mie, a pare deh neuer sea 20 cap, culegé it ml enpiatl se cnr Lcearecapoltgoal. Penta cau te tut tei seu paste Membrane insnt de cnt se spl cu te Sa ‘Siren otc ntraes a netercars a ae Seclevlearh mae. ‘conju apa. Desh au nt alte indica in aonograta partly ‘stile in as de ace mete ou tebe a deplgec > 105, cu exe {Sou came eave se permite vara atte Se pin a2 23 ‘act mal de dou cape, suas mal eve au aii Saceiet ies des 10 25 se deter att Towel local cyan hs mi mal de 255. ‘omstecul cna dn 20 cape ot 60 se flee pent: deter cnc caniath a aanelr mdiamentoae ale lad win mno- rite rarscale. Determiaaren onegent sd Pera capsle ce contin 0S 4 Bs yi sibtnfh medictoth a totes, onosecien ete Per smi esa Maple ‘ns heave din 10 capsule determin canta sustants medicaments 8, dor8ineais minora ocerpuneKon. Varia sbsanfe! meer entose poate fms mul de #155 Inconel medi, cu exenta ‘recap, lca s permite varia 2255. Doc in 10 caps fn dul connurulubstanet mecamentase dep eve inele mai mit de 2155, determin confit sutanfel mecca ntone nacre in ele 20capele mae. ‘ml et apelin 30 pot aen vrai den mest ma ml 2156 tah mame 2258. Desagresores, Capac destnte admins interme weble 2h 28 decaeege In tata gntelnestnal, Detrmiaren devagreie se face meacpaiet"Cmpinate” ‘Decl in mewagslile prtelere sot alie Snel, cpmleleelat sas oe esgrege el limi subitanfele medicaments ul ‘nt de 20min, Penta cnet 6 recomandS de determina dessa ‘in aparatl “exploit” pt eau ‘aed capsule it etersnuble be nu ehue ss descompund inp (oh ven opi cal int rh sari. tein Trait de smear carulele elation cele acopeate se seufund eva scunde a pt ee, Guph ces ght un aot ceva gure “Soubitate. Se ae conto ndciel manograies"Conprmate” ‘Aralorek ives ene efoto wn ne ch it de ‘Concerares, Cape webue conserva ne wet,