waktu

0
0.25
0.5
0.75
1
2
4
6
10
14
20

Cp (mcg/ml)
0
2.85
5.43
7.75
9.84
16.2
22.15
23.01
19.09
13.9
7.97

ln Cp
1.05
1.69
2.05
2.29
2.79
3.10
3.14
2.95
2.63
2.08

kel

ln Cp`

-0.087771 -0.999132

3.82
3.80
3.77
3.75
3.66
3.49
3.31
2.96
2.61
2.08

Cp`
45.47
44.48
43.52
42.57
38.99
32.71
27.45
19.32
13.60
8.03

ln Cp
3.5
3
2.5
2
1.5
1
0.5
0

ln Cp

10

15

20

25

delta =(Cp`-Cp)

ln delta

42.62
39.05
35.77
32.73
22.79
10.56
4.44

ka

3.75 0.3909137
3.66
3.58
3.49
3.13
2.36
1.49

4.00
3.50

f(x) = - 0.3909136855x + 3.8749163933

R = 0.9986610837

3.00
2.50
2.00

Column I

1.50

Linear (Column I)

1.00
0.50
0.00
0

3.50
3.00

f(x) = - 0.0877705969x + 3.8395480776

R = 0.9982644724

2.50
2.00

Column C

1.50

Linear (Column C)

1.00
0.50
0.00
8

10

12

14

16

18

20

22

waktu(jam)

Cp(mgc/ml)

0
0.25
0.5
1
1.5
2
2.5
3.5
5.5
7.5
9.5
11.5
13.5

ln Cp

0
1.9
3.4
12
38.2
50.1
44.9
33.2
18
9.5
5
2.62
1.39

kel

ln Cp`

0.64
1.22
2.48
3.64
3.91
3.80
3.50
2.89
2.25
1.61 -0.320034 -0.999984
0.96
0.33

Cp`

4.73
4.81
4.97
5.13
5.29
5.45
5.77
6.41
7.05
7.69
8.33
8.97

1.80
1.60

f(x) = - 0.3200335413x + 4.647691051

R = 0.9999687602

1.40
1.20
1.00

Column C

0.80

Linear (Column C)

0.60
0.40
0.20
0.00
9

10

11

12

13

14

112.96
122.36
143.60
168.51
197.75
232.06
319.58
606.07
1149.41
2179.83
4134.00
7840.05

delta= Cp`-Cp

ln delta

ka
1.80

111.06
118.96
131.60
130.31
147.65
187.16
286.38
588.07
1139.91

4.710036 0.332496
4.778821
4.879732
4.869923
4.99484
5.231969
5.657311
6.376851
7.038701

1.60

f(x) = - 0.3200335413x + 4.6476

R = 0.9999687602

1.40
1.20
1.00
0.80
0.60
0.40
0.20
0.00
9

9.5 10 10.5 11 11.5 12 12.5 13

ln Cp
5
4

ln Cp

Linear (ln Cp)

2
1
0
0

10

12

14

16

) = - 0.3200335413x + 4.647691051
= 0.9999687602

0 10.5 11 11.5 12 12.5 13 13.5 14

Column C
Linear (Column C)

waktu
0
0.25
0.5
0.75
1
2
4
6
10
14
20

Cp (mcg/ml)
0
2.85
5.43
7.75
9.84
16.2
22.15
23.01
19.09
13.9
7.97

ln Cp
1.05
1.69
2.05
2.29
2.79
3.10
3.14
2.95
2.63
2.08

kel

-0.087770597

AUC t-1-t
0.35625
1.035
1.6475
2.19875
13.02
38.35
45.16
84.2
65.98
65.61

AUC 0-t
0
0.35625
1.39125
3.03875
5.2375
18.2575
56.6075
101.7675
185.9675
251.9475
317.5575

AUC t-
90.8049

AUC 0-
408.3624
408.3624
408.3624
408.3624
408.3624
408.3624
408.3624
408.3624
408.3624
408.3624

Cp+K[AUC]0-t
2.881243125
5.552012625
8.016498375
10.29932875
17.80118275
27.11447775
31.93500975
35.39934975
35.99579575
35.81979275

K[AUC]0-
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309
35.5275285309

FAB

FTA

ln FTA

0.081099
0.156274
0.225642
0.289897
0.501053
0.763196
0.898881
0.996392
1.01318
1.008226

0.918901
0.843726
0.774358
0.710103
0.498947
0.236804
0.101119
0.003608
-0.01318
-0.008226

-0.084577
-0.169927
-0.255721
-0.342345
-0.695256
-1.440524
-2.291454
-5.624637

Kab
0.34364