Bi tp tng hp

Bi 1: ngh cng thc cu to cht M1

a. Ph ESI-MS

b. Ph 1H-NMR (CD3OD, 500MHz)

c. Ph 13C-NMR (CD3OD, 125MHz)

c. Ph 13C-NMR, DEPT (CD3OD, 125MHz)

Bi 2: Cho ph 1H NMR (CDCl3 , 300 MHz) v 13C NMR (CDCl3, 75MHz) ca mt hp cht hu c M2.
Hy phn tch d liu cc ph v ngh cu trc ca hp cht ny.

a) Ph 1H-NMR

b) Ph dn vng 9.2 ppm

c) Ph dn vng 0.4 2.5 ppm

d) Ph dn vng 5.6 6.8 ppm

e) 13C NMR (CDCl3 , 75 MHz)

Bi 3: Di y l cc ph IR, MS, 1H, 13C NMR ca mt hp cht hu c M3. Hy gii thch

cc ph v ngh cu trc ca cht ny.

FT-IR ca M3

Ph EI-MS ca M3

Ph 1H-NMR (D2O, 500MHz) ca M3

Ph 13C-NMR (D2O, 125MHz) ca M3

Bi 4: Cho ph 1H-, 13C-NMR v IR ca mt hp cht hu c k hiu M4. Hy phn tch d liu cc ph

v ngh cu trc ca hp cht M4. Bit ph EI-MS ca hp cht M4 cho pic ion phn t ti m/z 96.
1

H-NMR (300MHz) ca M4

13

C-NMR ca M4

FT- IR ca M4

Bi 5: Cho ph 1H-, 13C-NMR v IR ca mt hp cht hu c k hiu M5. Hy phn tch d liu cc ph

v ngh cu trc ca hp cht M5. Bit ph EI-MS ca hp cht M5 cho pic ion phn t ti m/z 180.
1

H-NMR (300MHz) ca M5

13

C-NMR ca M5

FT- IR ca M5

Bi 6: Di y l cc ph 1H, 13C NMR ca mt hp cht hu c M6. Hy gii thch cc ph

v ngh cu trc ca cht ny. Bit trn ph ESI-MS ion m cho pic ion gi phn t ti m/z
117.

Ph 13C-NMR (D2O, 125MHz) ca M6

Ph 1H-NMR (D2O, 500MHz) ca M6

Ph dn 1H-NMR (D2O, 500MHz) ca M6