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Lecture17 Carbohydrates Preview-Keywords
Lecture17 Carbohydrates Preview-Keywords
Carbohydrates
Metabolic importance
Precursor of glucose and other monomeric sugars
Fun facts
Composition of human body
Food materials with carbohydrates - Starch
Carbohydrates - Overview
General chemical formula
Importance
Single most abundant class of organic molecules in nature
Major form of stored energy
Structural roles
Covalent connection with proteins and lipids
Starch
Molecular structure
Monomer
D vs L
D is predominant in nature
Polymer
glycosidic bonds
hydrogen bonds
Monosaccharides
Aldose
Ketose
3-7 carbons
derivatives
sugar acids
sugar alcohols
deoxy sugars
sugar esters
amino sugars
phospho sugars
Example: ATP
Oligosaccharides
Formation from monosaccharides
two hydroxylic groups
removal of water
glycosidic bond
Examples
Lactose
hydrolysis of glycosidic bond by lactase
Lactose intolerance
Sucrose
Maltose
Cellobiose
Polysaccharides
Starch
Amylose
linear chain
Amylopectin
branched chain
amylase
alpha(1,6) glucosidase
Glycogen
Cellulose
Compare with Amylose
Chitin
Examples
Fungi (cell walls)
Crustacea and insects (exoskeletons)
Peptidoglycans
Polysaccharides linked to peptides
Bacterial cell walls
Gram-positive bacteria
Thick cell wall (25 nm)
Multiple layers of peptidoglycans
Gram-negative bacteria
Thin cell wall (2-3 nm)
Single layer of peptidoglycans
inner and outer lipid bilayer membranes
molecular composition
Compare with Chitin
Tetrapeptide: Ala-isoglutamate-Lys-Ala
Linkages
NAM (lactate moiety) - Ala
Lys to Ala in adjacent peptide
Direct
Gram-negative
through pentaglycine chain
Gram-positive