A new revolution in treating Joint Pain A Full Range of Motions & Emotions Preservation An effective cutting edge — treatment for t Sahq| Therapy™ Joint Pain An Australian Patented SVF Technology andWhatis Arthritis ? Arthritis is chronic inflammatory progressive joint disease which refers to severe joint- pain or joint-disease. The most common type of arthritis is Osteoarthritis (OA) and Rheumatoid Arthritis (RA). OA affects elder people while RA affects younger age group. Common arthritis symptoms include swelling, pain, stiffness and decreased range of motion. Symptoms may come and go. They can be mild, moderate or severe.They may stay about the same for years or may progress or even get worse over time. Severe arthritis can result in chronic pain, inability to do daily activities, difficulty in walking or climbing stairs & may even lead to complete physical immobility. Reason of painin Arthritis In OA, loss of cartilage / erosion (cushioning surface) causes rubbing of bones against another causing pain, swelling and stiffness. Over time, joints can lose strength and pain may become chronic. Excess body weight, family history, age and previous injury increases the risk further. STAGE OF KNEE OSTEOARTHRITIS I W MM Vv Doubtful Mild Moderate SevereTreatment Options + Medication : Pain killers or anti-inflammatory medicines, steroids etc. long term use of these may effect vital organs such as kidney, liver etc + Physiotherapy + Surgery : Only for grade - IV OA - Total Knee Replacement / High Tibial Osteotomy / Partial Knee Replacement + Joint Preservation : Autologous SVF grafting Whatis Grafting ? Grafting refers to a surgical procedure to move tissue from one site to another in the body, orfrom another person Classified into these two classes: + Autologus grafting + Allogeneicgrafting Whatis Autologus Grafting? Autologus graft is taken from one part of the body of an individual and transplanted onto another site in the same individual There are several type of Autologus grafting has been done surgically suchas: + Skin grafting + Bone grafting + Vascular grafting + Vascular conduit (asin bypass surgery arterial or venous graft) + Autologous blood component transfusion (such as plasma, concentrated platelets extracted from whole blood) + Autologous SVF Grafting of Lipoaspirate adipose tissuefor arthritis About Autologous Stromal Vascular Fraction (SVF) SVF contains a heterogeneous mix of cells, which is known to contain adipose tissue- derived stromal cells (ASCs), mesenchymal cells, progenitor cells, Pericytes, T-regulatory cells, EPC (endothelial progenitor cells), anti-inflammatory M2 macrophages and many other cell types . When fat cells (adipocytes) and the collagen that binds adipose tissue together are removed using SVF technology, just the stromal vascular fraction (SVF) cells remain. SVF contains heterologous mixture of cells with growth factors thus SVF is not a stem celltherapy. Autologous Stromal Vascular Fraction grafting is an Australian Patented technology for treatment of joint pains. This technology is successfully running in Australia since 2009 and thousands of patients were successfully treated there. This technology is available in United States of America (USA) and in many more countries. Autologus Stromal Vascular Fraction (SVF) is a type of Autologus grafting done ina single surgical sitting which is already in use for long time with proven safety and efficacy for treatment of Arthritis.SVF Process In this process around 300 - 400 ml fat is aspirated from the tummy of patient under local anesthesia then by using Australian patented technology SVF is isolated with in 50 minutes without using any enzymes, chemicals, animal products. Then under sonography guided Autologous SVF is grafted in intra articular space of effected joint in single surgical sitting. In this procedure there is: + Nouseofany chemical, + Nouseofany enzymes, culture of cell + Nouse ofany animal product. + As SVF grafting is an Autologus procedure so there is no chances of rejection and allergic reactions. Why SVF is best choice Autologous SVF is a one-day procedure which is safe, highly effective, painless with maximum regeneration potential & without adverse effects & morbidity. Itis minimally invasive & treats the underlying cause. It has proven value in remarkably improving quality of life Patient can go home walking the very next day. So far, there are no visible side effects of Autologous SVF grafting is reported. It improve the quality of life by accelerating the regeneration process in the affected area and provides biological solution for biological problem.Yes if you have joint pain adversely affecting your daily routine, Least invasive SVF which treats underlying cause is the ideal choice for you. + Osteoarthritis -OA All Gr. |, Il, Ill and IV* with less than 15° deformity + Rheumatoid Arthritis - RA + Avascular Necrosis of Hip Post SVF there is no vital impact on life style like + Patient can sit on floor + Can climb stairs + Can utilize Indian style toilets and many more. SVF treatment is not recommended for + Pregnant & lactating women + Patients with Gout or having active infection or HIV + Active cancer during previous 3 years.ales iste) E-Lecvaalal ES Australian SVF Patented Technology ICs Impact on bones Mechanism Invasion Anesthesia Recovery Treatment type Nature of Intervention Indication Revision Surgery Need for Revision Surgery Effect on life style Hospitalization Implant Rejection Effect on Cartilage regeneration Effect of body weight on outcome Age criteria Fitness for surgery Choice of treatment teu sele\eciaa ein) Inevitable loss of bone : Tibia, Femur & Patella Prosthesis Highly Invasive General / Spinal Extended Recovery Artificial Implant Mechanical 1-Grade -IVOA 2-Not suitable for RA Patients Difficult with poor outcome Generally required after 10 -12 years * Numerous restrictions Minimum stay of 4 -5 days Possibility It doesn't treat the underlying cause i.e. cartilage degeneration Poor result in case of obese patients Usually avoided for younger patients Patients must have good fitness to undergo this surgery 1-It should always be the second choice 2 - If it fails no other treatment is possible. Only alternative left is revision knee replacement surgery “As per clinical als, Except for more than 15' deformed joint SVF Technology ahaj Th Injection only hence no bone loss Natural Regenerative cells Minimally Invasive Local Easier & Quicker Autologous Cell Biological 1- All Grade of OA** 2 - Suitable for RA** also Easy Need may not be there* Substantial improvement One day hospitalization No rejection (As own cells) It treats underlying cause by cartilage regeneration Equally effective for all body weights Suitable for all age groups It is not a major limiting factor 1- It should be the first choice of treatment 2 - Ifit fails other treatment options are openLia PRP alone vs SVF Tela) Source Blood Adipose Tissue Contain Platelet reach plasma Heterogeneous mixture of cells Effect Lasting Short lasting effect More than 5 years* Regenerative Cells Absent Present Mechanism Doesn't directly replace Can replace damaged cells by dividing and damaged cells differentiating into the cell type needed Regeneration No capability of cell Capability of continuous cell regeneration regeneration Quantum of Reduces with time Regeneration continues Growth factors PRP AloneEfficacy of Autologous SVF Grafting Patient treated with Australian Patented Autologous SVF grafting obtained an average of 85% improvement in pain and mobility from degenerative joint disease. Global studies of more than a 7 years showed remarkable improvement in joint pain, quality of life and mobility. Unique feature of Sahaj Therapy + Noculture + Nouseofenzyme/chemical / animal product + Achieve more than 85% improvementin pain + Doneunderlocal anesthesia + Minimally invasive procedure + Treats underlying cause + Nosignificant adverse effect + Ageand body weight is nota limiting factor for patient selection +» Norisk of disease transfer- Autologous process For more information please contact 9 Sahaj Regenerative Cell Therapeutics LLP EE ol 15/2 South Tukoganj, Indore 452001 (M. P.) India ' (+91 731 2510 200, 252 9723, 91 82230 80555 @ wwwsahajtherapy.com ol 3 info@sahajtherapy.com Disclaimer Most data presented in ths brochure are base on publ shel studes an outcomes of clinical teas cared ou in ferent pats ofthe worl. Heath related information and opinions change frequently and therefore information contained in ths brochure may be outdated, incomplete or incoret. The information, statements and images provided in this brochure ifr informational purpose only & should not substitute advice proved by the treating physician