RISK FACTORS:

Cigarette smoking
PREDISPOSING
Obesity
FACTORS:
Hypertension
Von-Hippel Lindau
Occupational exposure
syndrome
to chemicals
Hereditary papillary
Chronic NSAID use
carcinoma
Long term renal dialysis
Birt-Hogg-Dube
Chronic hepatits C
syndrome
infection
Hereditary renal CA
Kidney stones

Short arm Chromosome 3p

Mutation
VHL tumor suppressor
gene

Increased IGF-1

Upregulates hypoxia inducible Dysregulated cell

factors

Upregulates vascular endothelial growth Epithelial cells from

factor Tumorigenesis proximal renal tubule

Angiogenesis

Sx:
hematuria,
flank pain,
palpable
mass, RCC