Conduction Excitability
Local currents travel via gap
junctions in isotropic manner
Fast Fast sodium channel opens when
Respon the transmembrane potential of
se one region of the fiber changes
from the resting potential of -90
mV to threshold potential of -65
mV.
Conduction velocity is dependent
on the amplitude of AP, and the
amplitude of AP is equal to the
potential difference between the
fully depolarized and the fully
polarized regions of the cell
interior
Conduction velocity
determinants:
o The greater the amplitude
of AP, the more effective
the local stimuli in
depolarizing adjacent parts
of the membrane and the
more rapid is the wave of
depolarization.
o Resting membrane
potential: affects
amplitude and slope of
upstroke. Depolarization of
Vm leads to inactivation of
fast Na channels, which
decreases the amplitude of
AP and slop of upstroke,
which would then slow
conduction velocity.
Slow Threshold potential is -40 mV
Respon Conduction s much more slower
se Conduction is more readily
blocked
Atrial
Atrioventricular
Not excitable once fast
response is initiated,
only if partial
repolarization has been
achieved.
ERP: Interval to be able
to conduct another AP.
Na channels transitions
from inactivated to
closed during RRP.
Complete transition
happens at complete
repolarization.
Although another AP
can be induced at the
partial repolarization
already if the stimulus
is greater vs that one
on phase 4.
The later that the
stimulation in RRL, the
more increase in
amplitude and a
steeper upstroke.
Propagation velocity
increases here.
RRP extends well
beyond Phase 3, that
even if it is completely
repolarized, it's difficult
to elicit a response.
Ventricular