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HB F Binds Less Strongly To BPG Than Does HB A
HB F Binds Less Strongly To BPG Than Does HB A
Inthebchainofadulthemoglobin,
His143makesasaltbridgetoBPG.Inthefetalhemoglobin,thegchainhasanamino
acidsubstitutionofaserineforHis143.Thischangeofapositivelychargedamino
acidforaneutralonediminishesthenumberofcontactsbetweenthehemoglobin
andtheBPG,effectivelyreducingtheallostericeffectenoughtogivefetalhemoglo
binahigherbindingcurvethanadulthemoglobin.
^^solubofproteinvspH
chrom: