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HbFbindslessstronglytoBPGthandoesHbA.

Inthebchainofadulthemoglobin,
His143makesasaltbridgetoBPG.Inthefetalhemoglobin,thegchainhasanamino
acidsubstitutionofaserineforHis143.Thischangeofapositivelychargedamino
acidforaneutralonediminishesthenumberofcontactsbetweenthehemoglobin
andtheBPG,effectivelyreducingtheallostericeffectenoughtogivefetalhemoglo
binahigherbindingcurvethanadulthemoglobin.


^^solubofproteinvspH

chrom:

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