2 Plasmodium ite cycle ‘Asexual tage (bloodstream) Pate cyclen BCS Vroae Serer nets Sexual tage mosquito Fraatedevsiopment nthe mosauto Nature Reviews| InmunclooyTable 1 Malaria Sensitivity [Recommended Oru Adult and Pediatric Dose ‘Adverse EMects ‘Uncomplisied |A. Chloroquine: [Chiooquioe nae: a se cry ares by || Caren: aca, mais sense malaria phosphate calgon sea, visual aocommodation (Plasmedeom or? problems, cornea or einat ‘aleparum) hi: 1m tetra aay, towed y | gear ergo ie) ‘5 mpi at sx 24, and 48 Nouts Quinine suttate: cinchonism dose: 251mg basekp) pros, cardiac anhythmias, 8. Onoroqune-_ |The options: 542g ak (650g Sat) ray | yp, seats, resistant malar | Quinine site + | thee tesa ty for tee day for blindness, Fypootyceria lone ofthe following |inlections acnuied in Africa or South | Danyeycline: ( antiots: ‘Arnica and seven cays for infections | grra, nausea and voting, Daseyent or secured in Sous a pest ersten wh Netracycine or ‘Dazyeyeline: 100 mg tice a contraceptives (use ilindamycia ay for seen dys atpative bith contol eatin 2 a tes ec) mead day for seven Mellogene: nausea, dizrness, nda divided | neuropsychiatnc problems theee times a day for seven days (2.9, anit, depression, (Chil: quinine sls: 83 mg base oa pac, hallucinations thee tes. day for thre to seven days | Clindamyein: sina Cogent [srenseemt open, eoitis ren younger than 8 years) cea cde ben tb con tare Teresi phat) o vided four Ens a day fr seven dys Clindamyein: 20 mg bassin ory ines ay for seen days ober frrnp ey nag pnp ping |= Mefiog ‘664 mg base itialty, followed | Melloquine: chil, tat a Nara Rr craie kere Imeerin tcee, coaon irbances, ed be .1 mg base/kg six to 12 hours later. | psychosis. ECS changes diarrhea = ‘Uncomplicated [Al sensitive? [Chloroquine phosphate | Trestment as above malaise 19 [resistant malaria Pasmodian oe Uncomplicated |All sensitive’ Chloroquine phosphate | Adult: Chloroquine as abowe Primaquine: anemia in patients malaria due to jresistant malaria |+ primaquine phasphate | Primaquine: 30 mq base orally the GEPD deticiency, pruritus, Plasmodium aly for 14 days ‘contusion, abdominal eramps ier OF PESO | ‘visual desturbances: — ‘Uncomplicated [Chioroquine- Th tions: ‘Treatment 2s above malaria due to [resistant cn ‘sullate + doxy- ie P. vivax. jeydline or tetracycline Stemeaert oT [eens ms (peimaquine phosphate ‘Uncomplicated [A Chlorequine- |Ghiosoquine pbasphate | Treatment 23 above malaria: aptions | sensitive (not applicable to children) for pregnant = 8. Chioroquine- Quinine sulfate + Treatment a3 above ‘women sesistant P. {clindamycin (not applicabte to children) C. Chioroquine- Quinine suttate Treatment a3 above resistant P. vivax (not applicable to chikdnen) Severe malaria |Sensitiver [Quinine gluconate + | Adult all drugs are given intravenously resistant strains doxycycline or Child: al drugs are grven intravenously \cindamycin Se te COC Gt i Tm i eS 208 “Aro a wie gohan