WOMEN AND NEWBORN HEALTH SERVICE

King Edward Memorial Hospital

CLINICAL GUIDELINES
SECTION P: PHARMACY AND MEDICATIONS

MEDICATION A-Z
Date Issued: January, 2009 PHYTOMENADIONE (VITAMIN K)
Date Revised: July, 2012 Section P
Review Date: July, 2015 Clinical Guidelines
Authorised by: OGCCU King Edward Memorial Hospital
Review Team: OGCCU & Pharmacy Perth Western Australia
The information provided is for the use in Obstetrics and Gynaecology only

DRUG PHYTOMENADIONE (VITAMIN K)

Ampoule: 10mg in 1mL (IV,oral)
PRESENTATION Ampoule: 2mg in 0.2mL (paediatric)(IV/IM/Oral)
Oral: 10mg capsule
Essential co-factor in the synthesis of blood clotting factors ll, Vll, lX
ACTION and X and proteins C and S
Antagonist of some oral anticoagulants (warfarin)
Haemorrhage or threatened haemorrhage due to
INDICATION hypoprothrombinaemia
For pregnant women post 36 weeks gestation taking liver enzyme
inducing anti-convulsants (e.g. phenytoin, carbamazepine)
CONTRAINDICATIONS Should not be used in patients with pronounced allergic diathesis
Severe hepatic disease
PRECAUTIONS Elderly anti-coagulated patients may be more sensitive to parenteral
phytomendione
Excessive oral anticoagulant effect:
See MR810.11 Anticoagulation Medication Chart
IV: 0.5mg-10mg depending on INR and presence of minor or major
bleeding
Oral: 1mg-5mg depending on INR and presence of minor or major
DOSE bleeding
If intending to restart warfarin then use lowest possible dose

In conjunction with anti-convulsants post 36 weeks gestation:

Oral: 10mg daily

ADMINISTRATION
Anaphylaxis
ADVERSE EFFECTS Injection site reaction, phlebitis, facial flushing

COMMENTS IV : Slow IV bolus over at least 30 seconds

Ampoules (paediatric and adult): contents can be given orally
PREGNANCY May be used
LACTATION May be used

Clinical Guidelines Section C 4.1.3.2 Warfarin Therapy

CLINICAL GUIDELINE LINKS

Womens and Newborn Health Service Policy 027 Administration of

Other guideline links Parenteral Drugs

2008 All guidelines should be read in conjunction with the Disclaimer at the beginning of this manual Page 1 of 1