Ivermectin

Ivermectin is an injectable avermectin effective against endo- and ecto-parasites of cats[1].

Ivermectin is a macrocyclic lactone derived from fermentation of the bacteria Streptomyces
avermitilis. Other avermectins used on cats include selamectin.
Although shown to be effective in off-label use against Dirofilaria immitis and other filariids[2], Bot flies
(Cuterebra spp and Cochliomyia spp), fleas (Ctenocephalides felis, Ctenocephalides
canis, Echidnophaga gallinacea, Pulex irritans) and lice (Felicola subrostratus, Heterodoxus
spiniger), ivermectin has poor efficacy against some dermal mites such as Demodex spp[3]. Some
reports shown efficacy against Sarcoptes spp[4].
Ivermectin toxicity has been reported as a common occurrence in cats.
The recommended dose for injectable ivermectin is 0.1cc/kg SQ stat, or once weekly for
ectoparasites. Oral dose is 24 g/kg once monthly.

References
1. Jump up Chittrakarn S et al (2009) Pharmacokinetics of ivermectin in cats receiving a single
subcutaneous dose. Res Vet Sci 86(3):503-507

2. Jump up Chansiri G et al (2005) The efficacy of a single-oral-dose administration of

ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi. Southeast
Asian J Trop Med Public Health 36(5):1105-1109

3. Jump up Fisher MA & Shanks DJ (2008) A review of the off-label use of selamectin
(Stronghold/Revolution) in dogs and cats. Acta Vet Scand 50:46

4. Jump up Malik R et al (2006) Crusted scabies (sarcoptic mange) in four cats due to
Sarcoptes scabiei infestation. J Feline Med Surg 8(5):327-339

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