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HFL705 - Cobas 4800 HIF Manual 1.02 PDF
HFL705 - Cobas 4800 HIF Manual 1.02 PDF
DRAFT
cobas 4800 system Host interface Manual
Table of Contents
General 1
Target audience.................................................................................... 1
References .................................................................................... 1
....................................................................................
Document Revision History 1
.................................................................................... 2
Contacts, Trademarks
Glossary .................................................................................... 3
Overview 4
....................................................................................
Communication Overview 4
....................................................................................
Communication layers 5
Workflow 6
....................................................................................
Communication Scenarios 6
.................................................................................... 6
Work Order Inquiry
Message types 8
.................................................................................... 8
General Information
.................................................................................... 8
Full Run Inquiry
.................................................................................... 8
Full Order Response
.................................................................................... 10
Test Result Export
FLAGS .................................................................................... 13
ASTM Protocol 17
COBAS 4800 ....................................................................................
ASTM Record Definitions 19
....................................................................................
Inquiry records Mappings (ASTM) 20
H Segment.................................................................................... 20
P Segment .................................................................................... 21
Q Segment.................................................................................... 21
L Segment .................................................................................... 21
....................................................................................
Inquiry Response Mapping 22
H Segment.................................................................................... 22
P Segment .................................................................................... 23
O Segment.................................................................................... 23
L Segment .................................................................................... 24
Inquiry/response examples
.................................................................................... 25
....................................................................................
Results Mapping (ASTM) 26
H Segment.................................................................................... 26
P Segment .................................................................................... 27
O Segment.................................................................................... 27
R Segment .................................................................................... 28
L Segment .................................................................................... 28
....................................................................................
Results Example ASTM 29
HL7 Protocol 31
COBAS 4800 ....................................................................................
HL7 Record Definitions 32
....................................................................................
Inquiry Records mapping (HL7) 33
Inquiry Mapping
.................................................................................... 33
Inquiry Response Mapping
.................................................................................... 35
....................................................................................
Results Mapping (HL7) 37
Communication setup 42
.................................................................................... 42
Network connection
.................................................................................... 42
Instrument Setup
Simulator 43
.................................................................................... 43
Installing simulators
.................................................................................... 43
HL7 Simulator
Setting up the simulator connection
.................................................................................... 46
Connection....................................................................................
test 49
Sending an....................................................................................
order to the system 50
Receiving results from the system.
.................................................................................... 54
.................................................................................... 57
ASTM Simulator
Troubleshooting / logfiles 58
Known restrictions 58
1 General
Target audience
The intended audience for this manual is Host Interface programmers and the Roche Field engineers supporting the
system.
References
[1] HL 7 Documentation Version 2.4, Health Level Seven, Ann Arbor MI, USA, www.HL7.org
[2] ASTM Documentation 1394 LIS2
Note: Although ASTM and HL7 are the base of the data exchange, the result transmission
is not a strict ASTM or HL7 format.
The system presents CT/NG or HPV as global blocks of results and transmits them as such.
See the Result topics for the respective ASTM and HL7 formats for details.
Document Revision History
Information in this document is subject to change without notice. No part of this document may be reproduced or
transmitted in any form or by any means, electronic or mechanical, for any purpose, without the express written
permission of Roche Diagnostics GmbH.
Every effort has been made to ensure that all the information contained in this manual is correct at the time of publishing.
However, Roche Diagnostics Ltd. reserves the right to make any changes necessary without notice as part of ongoing
product development.
Document references
Contacts, Trademarks
Contact Addresses
Manufacturer Roche Diagnostics Ltd.
Forrenstrasse
CH-6343 Rotkreuz
Switzerland
Questions or comments regarding the contents of this manual can be directed to the address below or to your Roche
representative.
email: rotkreuz.gssmdi@roche.com
Trademarks
cobas is a trademark of Roche.
Glossary
MTS Medium Throughput System This name is sometimes used inside the protocol.
Where the Acronym MTS is used, it means the cobas 4800 system..
A&D Amplification and detection. The system will only perform Amplification and detection on already
prepared MWP, using the z 480 instrument.
The A&D runs are not supported by the LIS workflow.
AnD Same meaning as A&D - Often used inside records as the "&" character would be interpreted as
separator and therefore cannot be used.
Full run Samples will be prepared into a MWP by the cobas x 480, then the plate will be transferred manually
to the cobas z 480 for the A&D run.
GUID Stands for Global Unique Identifier.
A unique identifier created by the system. It is a 128 bits number written in a pattern of hexadecimal
numbers similar to : 3F2504E0-4F89-11D3-9A0C-0305E82C3301
It is used to identify a unique run in the transmission records.
MWP Microwell plates.
Transformer A software module that conforms XML communication files to the communication server.
cobas x 480 The cobas x 480 prepares the samples.
instrument The cobas x 480 is loaded with samples, consumables and reagents. After sample preparation, the
multiwell plate with the PCR-ready samples is unloaded, sealed, and transferred to the cobas z 480 for
amplification and detection.
cobas z 480 The cobas z 480 utilizes fluorescence to detect nucleic acids amplified by using realtime
analyzer PCR methodology. the loading and unloading of the multiwell plate is done manually.
2 Overview
The structure of the document is as follow
The topic General describes general functions of the subsystem or the unit having influence on the implementation.
This chapter contains no specifications but provides background information and context information for the
specifications stated in the next chapter. The goal is to increase the legibility of the document.
Topic HL7 contains all the specifications for the HL7 protocol.
Topic ASTM contains all the specifications for the ASTM protocol.
Communication Overview
The physical connection used by the cobas 4800 host interface is the standard network card (N.I.C) with Ethernet protocol.
The communication is realized by xml files which are exchanged and evaluated between cobas 4800 sw <-> Transformer
and Transformer <-> cobas 5000 IT Communications Server.
Communication layers
As all the communication is based on network connections, this manual addresses mostly the upper layer (application)
related topics.
This layer corresponds to the upper layer in the well known OSI model:
3 Workflow
Communication Scenarios
The following table shows the communication scenarios existing for the cobas 4800.
Once the LIS has been enable by Roche support, the LIS must always respond to order requests.
There is no possibility to work with "results sending only" and manually ordering.
If the LIS cannot respond to order requests, the system cannot run tests unless the LIS is disabled again to work completely
offline.
Missing orders:
When sample numbers are received that do not have a corresponding test request in the Host system, the whole sample
record must be skipped.
No "empty" orders shall be sent to the cobas 4800, otherwise it will result into a complete order upload failure.
See in Each protocol for details.
When order numbers are skipped, the mismatch will be signaled on the screen as shown below (1):
(Mismatch occurred between loaded and expected samples
Please press "Unload Sample" )
1. Unload the sample rack(s), remove the indicated sample tubes (2), reload the sample rack. or
2. Unload the sample rack, add orders to the indicated samples into the LIS system, reload the sample rack(s)
Result export
The results can be manually exported to the LIS using the selected protocol (ASTM or HL7).
The total transmission time should not exceed 120 seconds otherwise the last results may not be transmitted.
4 Message types
General Information
The Full run, the A&D Only run and the result export have different data to transfer.
The following tables show the detail of this data.
CT/NG CT/NG
CT
NG
HPV HPV High Risk Panel + Genotyping
HPV High Risk Panel
For each
Sample
Test Result Examples: OBX-5-1 R-4-1
Invalid ;
CT POS, NG POS ;
CT POS, NG POS CT Positive, NG Positive. Specimen is positive for the presence of both
CT and NG DNA.
Table 8
Other HR HPV NEG, HPV16 NEG, HPV18 Other High Risk HPV Negative*, HPV16 Negative*, HPV18 Negative*.
NEG HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68
DNA were undetectable or below the pre-set threshold.
Invalid Invalid. The results are Invalid. Original specimen should be re-tested to
obtain valid results.
No Result for Specimen Consult the cobas 4800 system Operators
Failed Manual for instructions to review run flags and recommended actions.
Original specimen should be re-tested to obtain valid results.
FLAGS
Result Interpretation Table 9
R9 RI Error The test should have at least one target and at least one internal control.
R19 RI Error The Ct ranges for the intermediate interpretation are invalid.
Calculation Table 11
C9 CP Error The test should have at least one target and at least one internal control.
C12 CP Error The specified algorithm is not supported by this calculation package.
C13 CP Error The specified algorithm version is not supported by this calculation package.
C14 CP Error The calculation parameters for the numeric algorithm are incomplete.
C105 XT Error The length of the background vector is not equal with CrossTalkMatrix
filter combinations count.
C106 XT Error Matrix coefficients calculation has failed.
C108 XT Error Resolution matrix size and channel count do not match.
X3 SPI Error Clot detected for a sample. This sample will have an invalid result.
X4 SPI Error Not enough liquid while processing a sample. This sample will have an invalid
result.
X5 SPI Error Reagent onboard time exceeded when the user tried to start the sample
preparation process. The run was aborted.
X6 SPI Error Working Master Mix with extract timed out after sample preparation has finished.
The run was aborted.
X7 SPI Error Error during processing of external control. Run results will be invalid.
X8 SPI Error Hardware or software error from the instrument. Processing of the sample was
aborted.
After a test run the results are shown to the user and become available to be exported. Figure 2 shows this scenario.
6 ASTM Protocol
The cobas 4800 ASTM protocol also implements the ASTM E1381-91 Low Level Protocol, although this is not the focus of
this manual. No changes can be made at this level and because the system is implemented over a network communication,
it just acts as an intermediate level inside the application layer, transmitting the data to the upper ASTM layer.
The short description of the ASTM lower layer is here for information.
Frame Configurations
For one frame, maximum of 240 characters for text, 7 characters for frame control characters (not included in the 240).
Messages equal to or less than 240 characters are transmitted as one final frame.
Messages greater than 240 characters are split into frames that have character lengths that fall within the 240-character
limit.
The only or final remaining frame becomes the last frame and is indicated by <ETX>. All others are intermediate (middle)
frames and are indicated by <ETB>.
Results timeout:
Timeout for messages sent by the cobas 4800 system: From the ENQ, the transmission including multiple frames should
not exceed 120 seconds. Intermediate frames sent past this time will not be sent, the system will close the transmission with
an EOT,
P Segment
The MTS software doesnt have any patient informations but the ASTM protocol does need a P record.
Q Segment
L Segment
ASTM Inquiry L Segment (Message Terminator)
Segment Type Comment Values Required
Name and
Number
L-1 String This field is coded as L. L Yes
L-2 int The Terminator field 1 Yes
This table is showing the field mappings between the MTS xml file / Transformer and the ASTM message header segment.
P Segment
The cobas 4800 software does not have any patient information but the ASTM protocol does need a P record.
O Segment
This table is showing the field mappings between the MTS xml file / Transformer and the ASTM test order segment.
The test order segment is holding all information related to a sample.
Note: Missing orders. For samples that do not have a corresponding test request in the Host system, the whole O segment
record must be skipped.
O-16 String Media Type. Allowed values, see Table 9 String ex: UT Yes
O-17 String Contents the user who has created the order admin Yes
Note 1: A&D mode not supported by LIMS workflow
L Segment
ASTM response L Segment (Message Terminator)
Segment Type Comment Values Required
Name and
Number
L-1 String This field is coded as L. L Yes
L-2 int The Terminator field 1 Yes
Inquiry/response examples
outgoing - ASTM:
H|\^&|||MTS^65745d86-7a00-49ae-98b3-8a67d18f8e31^none^0.9.8.0912^1394.
LIS2|||||LIS|TSREQ^REAL|P|1|20090403081313|
P|1|
Q|1|^15200049\15200059\15200043\15200073\15200013\15200071\15200041
\15200011\15200069\15200039\15200009\15200067\15200037\15200007\15200065
\15200035\15200005\15200093\15200063\15200033\15200003\15200091\15200061
\15200031\15200027||^^^CT/NG^^Full|
L|1|
incoming - ASTM:
H|\^&|||LIS^65745d86-7a00-49ae-98b3-8a67d18f8e31^none^0.9.8.0912^1394.
LIS2|||||MTS|TSREQ^REAL|P|1|20090403083315|
P|1
O|1|15200049^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|2|15200059^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|3|15200043^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|4|15200073^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|6|15200071^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|7|15200041^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|8|15200011^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|9|15200069^^||^^^CT/NG^CT^Full|||20090403083315||||||||UT|none
O|10|15200039^^||^^^CT/NG^NG^Full|||20090403083315||||||||UT|none
O|11|15200009^^||^^^CT/NG^CT/NG^Full|||20090403083315||||||||UT|none
O|12|15200067^^||^^^CT/NG^CT/NG^Full|||20090403083315||||||||UUT|none
O|13|15200037^^||^^^CT/NG^NG^Full|||20090403083315||||||||UUT|none
O|14|15200007^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|15|15200065^^||^^^CT/NG^CT^Full|||20090403083315||||||||UUT|none
O|16|15200035^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|17|15200005^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|18|15200093^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|19|15200063^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|20|15200033^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|21|15200003^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|22|15200091^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|23|15200061^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|24|15200031^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
O|94|15200027^^||^^^CT/NG^CT^Full|||20090403083316||||||||UUT|none
L|1
Note: When sample numbers are received that do not have a corresponding test request in the Host system, the whole
sample record must be skipped.
No "empty" orders shall be sent to the cobas 4800, otherwise it will result into a complete order upload failure.
Example: If the sample numbers 15200065 and 15200027 do not have a test for cobas 4800, the lines marked in bold in the
ASTM response from the Host would not exist.
This table is showing the field mappings between the MTS xml file / Transformer and the ASTM message header segment.
P Segment
The cobas 4800 software does not have any patient information but the ASTM protocol does need a P record.
O Segment
This table is showing the field mappings between the MTS xml file / Transformer and the ASTM test order segment.
The test order segment is holding all information related to a sample.
O-17 String Contents the user who has created the order admin Yes
O-26 String Type of Results: F=Final Results; P=preliminary F or P Yes
results depends of the result export flag
ccepted.
F Means result was accepted
P Means result was not accepted (yet)
.
R Segment
Note:
The system presents CT/NG or HPV as global blocks of results and transmits them as such.
The Host system may have to further parse the result block if a further separation of individual subcomponents is required
. See the tables 11 for details and possible combinations inside result blocks.
L Segment
outgoing - ASTM:
||||||Labmanager|20090825140628|20090825170656|
[CR][ETX]C2[CR][LF]
HOST 00:11:54,194 [ACK]
c4800 00:11:54,294 [STX]7O|7|RDR0003435^AD6002095^C1||CT/NG^Full||
|20090825020548|||||||20090825141222|UT||||||||
||F|[CR][ETX]95[CR][LF]
HOST 00:11:54,304 [ACK]
c4800 00:11:54,404 [STX]0R|1|^^^CT/NG^CT/NG^Full|CTNEG,NGNEG^
X2|||||||Labmanager|20090825140628|200908251706
56|[CR][ETX]4E[CR][LF]
HOST 00:11:54,414 [ACK]
c4800 00:11:54,515 [STX]1O|8|RDR0003436^AD6002095^D1||CT/NG^Full||
|20090825020548|||||||20090825141222|UT||||||||
||F|[CR][ETX]92[CR][LF]
HOST 00:11:54,525 [ACK]
c4800 00:11:54,625 [STX]2R|1|^^^CT/NG^CT/NG^Full|CTNEG,NGNEG^
|||||||Labmanager|20090825140628|20090825170656
|[CR][ETX]C6[CR][LF]
HOST 00:11:54,635 [ACK]
c4800 00:11:54,725 [STX]3L|1|[CR][ETX]B8[CR][LF]
HOST 00:11:54,735 [ACK]
c4800 00:11:54,835 [EOT]
Note: The bullet character inside results is just a placeholder to visualize the spaces inside strings.
example |CTPOS,NGNEG^| should look in reality: |CT POS, NG NEG^|
The character used in the transmission is a regular space (Hex 20).
outgoing - ASTM:
7 HL7 Protocol
Minimal Layer Protocol
The data framing uses the MLLP, Minimal Lower Layer Protocol defined in the HL7
standard.
HL7 messages are embedded in block delimited by special (non printable) characters.
<start_block>data<end_block><CR>
The values of the special characters are <VT> for the start block and <FS> for the end block. See table below.
Data (variable number of bytes) The HL7 data is comprised of any displayable ASCII characters
and the carriage return character, <CR>.
Message Structure
The Message structures are defined in the syntax also used in [1] 1
OBR-27 XML Xml DateTime of the message put by the YYYYMMDDhhmmss Yes
DateTime creating system on creation of this message e.g. 20081122121212
Note 2 : Missing orders For samples that do not have a corresponding test request in the Host system, the whole ORC +
OBR segment records pair must be skipped.
This table is showing the field mappings between the cobas 4800 xml file / Transformer and the HL7 message observation
request segment.
The observation request segment is holding all information related to a sample.
Note:
The system presents CT/NG or HPV as global blocks of results and transmits them as such.
The Host system may have to further parse the result block if a further separation of individual subcomponents is required
. See the tables 11 for details and possible combinations inside result blocks.
26154328|||||||PC||||||||||||20090826114803|[CR
]
c4800 10:14:27,335 OBX|7|ST|R0000818^AD6002084^H1||OtherHRHPVIn
valid,HPV16Invalid,HPV18POS^||||||P|||||Lab
manager|[CR]
c4800 10:14:27,351 ORC|8||||||^^^20090826114803||||[CR]
c4800 10:14:27,351 OBR|8||2H1M015776A02IG^AD6002084^A1|HPV^N/A^Ful
l|||20090826120921|20090826154328|||||||PosCtrl
||||||||||||20090826114803|[CR]
c4800 10:14:27,351 OBX|8|ST|2H1M015776A02IG^AD6002084^A1||Valid^^C
T_DYE3~37.381362915039062~CT_DYE5~35.7265472412
10938~CT_DYE1~36.203384399414062~CT_DYE0~35.940
170288085938||||||
Note: The bullet character inside results is just a placeholder to visualize the spaces inside strings.
example OtherHRHPVPOS should look in reality: Other HR HPV POS
The character used in the transmission is a regular space (Hex 20).
outgoing - HL7:
8 Communication setup
Network connection
The physical connection used by the cobas 4800 host interface is the standard network card (N.I.C) with Ethernet protocol.
The network address of the instrument is normally determined by the installation of a cobas IT firewall.
To change the network address, you must log into the operating system as local Administrator.
Please ask the Roche service representative.
Instrument Setup
By default the HIF modules are not installed, for the instrument setup, please refer to the Network Configuration Guide
cobas 4800 system.
This installation has to be performed by qualified Roche service personnel.
Once the software for host interface has been installed, some parameters can be changed to match the requirements of the
LIS system.
The default protocol after installation is HL7. To change to ASTM, or back to HL7, change the target IP (LIS system) or the
port, see the the Network Configuration Guide cobas 4800 system.
9 Simulator
Installing simulators
Roche has developed specific host simulators to make simple testing of the ASTM or HL7 protocol, for the cobas 4800
Instrument.
This software can be installed on Windows computers and are intended to be used only by Roche trained personnel.
When used as an instrument simulator, the goal is to provide only a quick test tool for testing the transmission formats.
Please keep in mind that the simulator does not react like a real instruments in all situations.
The simulator is intended to be used for several Roche instruments, periodically new ones will
be added.
From version 2.0 on, all the host interface tools come together in a common installation package.
Requirements
The Roche ASTM/HL7 simulators can be installed on Windows XP computers.
The user needs administrator rights to be able to install the host tools package properly.
After the basic installation of the "Host tools" package, some patches may be required depending on the simulator you
intend to use.
Please ask the Roche service representative for further information.
Software requirement:
Windows XP professional SP2, with current patches.
Access to network settings
Recommended hardware:
Any computer able to run Windows XP professional.
Network card
HL7 Simulator
Roche has developed a specific host simulator to make simple testing of the HL7 protocol, for
the cobas 4800 Instrument.
To start the simulator, simply select from the stat menu as shown.
The simulator must be set up as a server. That is, it will listen on a defined port. Port 5555 is often used as a default.
The server IP address is the address of the network card and cannot be changed for a server.
It comes from the network settings of the computer hosting the simulator.
This is the same as the LIS address that must be set on the cobas 4800 when installing or setting up the Host. See
Instrument setup 42
Select the Instrument "cobas 4800" from the drop down list and "Host" as shown. This has the effect of enabling the
correct responses from the simulator to the selected type of instrument.
Note: The simulator can also simulate a cobas 4800 system, but this mode goes beyond the scope of this manual
Once parameters are setup correctly the simulator will start listening on the defined port. Once every minute, the cobas
4800 communication server will attempt a connection on the defined IP address and port.
If the simulator is reached, the connection indicator will turn from yellow to green as shown.
Additionally, the IP address of the connected system will appear in the lower part of the blue box (Remote).
At this point the simulator can be used and will display the HL7 records received and sent.
Connection test
When the simulator is connected, the connection test gives a possibility to check the responsiveness of the client.
If the LIS seems unresponsive although the connection is displayed as active, make the connection check.
In case of test failure, close the simulator and restart it. If the connection is not re-established within two minutes,
shutdown the cobas 4800 system and restart it.
There are further fields on the right that can be edited: (Use lower slide bar to view them).
Note: Be aware that the simulator does not perform any check on the type of data. Verify with the
protocol definitions that you enter valid data. For example, if you type a number where another
type is required, an error will probably be generated at the instrument level and the order rejected.
(see also restrictions 58 )
Go to 1)utilities tab, select 2) configuration tab, select 3) System Settings and 4) enable the checkbox LIS present.
TO be able to transmit results, once the LIS has been activated, it is necessary to log in as
All results present in the page will be transmitted, even if only one is selected.
Results received by the simulator will be stored in the database as shown below.
ASTM Simulator
Roche has developed a specific host simulator to make simple testing of the ASTM protocol, for
the cobas 4800 Instrument.
This software can be used on Windows XP computers and can be delivered upon request.
Contact your Roche Diagnostics representative.
The simulator is intended to be used for several Roche instruments, periodically new ones will
be added.
Requirements
The Roche ASTM simulator can be installed on Windows XP computers and is part of the complete host tools package.
refer to the previous topic HL7 simulator, the ASTM simulator works in a very similar way and shares the loacl simulator
database with the HL7 simulator.
The user needs administrator rights to be able to install the host tools package properly.
Software requirement:
Windows XP professional SP2, with current patches.
Access to network settings
Recommended hardware:
Any computer able to run Windows XP professional.
Network card
10 Troubleshooting / logfiles
Troubleshoting:
Most errors in the incoming communications i.e. a missing parameter in a filed, will result in a timeout message on the
instrument.
Errors generated by the conversion from incoming HTML or ASTM are not passed to the application, the Transformer
program will only pass XML files if the parsing or the different fields succeeds. If any error occur it will just stop parsing
the information and do nothing, therefore if the application is awaiting an answer, it will just timeout. To find the source
of the problem, see the logfiles section.
If the cobas 4800 system has an active connection to the host system but fails to request order information after loading
sample racks, one possible cause is the "operator" is not logged into the operating system of the cobas 4800 control unit.
If an administrator is logged into the windows operating system, the LIS service will connect to the ASTM or HL7 server
but the system will not be able to communicate.
Corrective action: log off the administrator user in Windows, the system will automatically re-log as "operator"
Logfiles:
In the directory c:\data\log, the trafic for the selected protocol is logged:
The transformation activity of the transformer program .xml <=> active protocol is logged in the file cserver.log
cserver logfiles are collections of incremental files like cserver.log.1, cserver.log.2 .......
As soon as the cserver.log reaches a size of 1025 kB, a number is appended to the extension and a new cserver.log is
created.
To find the captured errors, open the file with the windows notepad program and make a search fro "ERROR".
You may find some limited indications about protocol errors. (e.g an incorrect type or missing mandatory parameter).
11 Known restrictions
Workflow:
Only the Full run is supported by LIS. The "A&D" and "Sample extraction only" modes are not supported by the LIS
system.
The timeout after an order request from the instrument is currently set at 30 seconds and cannot be changed.
Because of this relatively short time out, it is recommended to use only direct network connections between the LIS and
the cobas 4800 system. Avoid any bottlenecks, i.e. converters to RS232 serial line. Order processing on the LIS should be
optimized to avois a timeout when loading the maximum samples.
Troubleshooting errors:
In case of protocol errors (i.e. the LIS sending an incorrect data type or unexpected values), the instrument will report
LIS system does not answer (timeout) in most cases.
This can be misleading, however some information might be available in the logfiles. See Troubleshooting 58
ASTM:
Field O-8 if left blank will not create a failure, although this is documented as required field.
HL7:
No Known problem
-C-
Calculation 13
checksum 17
Client /Server structure 4
cobas x 480 3
cobas z 480 3
Control character 17
-D-
data framing 31
-E-
empty orders 6
error 13, 50
errors 58
-F-
FLAGS 13
Frame
final frame 17
intermediate frame 17
Length of the Frame 17
Middle Frame 17
Full 6
Full run 3, 8
-G-
GUID 3, 20, 22, 26, 33, 35
-H-
host simulator 43
-I-
inquiry timeout 6
installation Manual 42
-L-
layer 5
Logfiles 58
-M-
Media Type 8
Message Terminator 24
Micro Well Plate 3
Minimal Layer
Minimal Layer Protocol 31
Missing orders 6, 23, 35
MLLP 31
MTS 3
MWP 3
MWP plate 6
-N-
Network Configuration Guide 42
-O-
order request 50
OSI model 5
-P-
patient information 23, 27
physical connection 4
-R-
requirement 43
Requirements 43
reserveCyt 8
Results timeout 17
run 8
Run Type 6, 8
-S-
server 6, 46
server IP address 46
simulator 43, 57
Database 50
Simulator database 50
Simulator Database 50
special characters
FS 31
VT 31
SPI 13
SubTestType 8
SurePath 8
-T-
TCP/IP client 4
TCP/IP server 4
Test Type 6, 8
timeout 6, 58
Timeout (Results) 17
Transformer 4
transmit results 54
-U-
UniTrans 8
Urine UniTrans 8
-W-
Warning 13
Work Order 6
Work order inquiry timeout 6
Workflow 58
Personal notes:
Roche Diagnostics Ltd.
Forrenstrasse
CH-6343 Rotkreuz
2009 Roche Diagnostics Ltd. Switzerland
19-Mar-10