The new england

journal of medicine
Leukotriene Antagonists as First-Line or
Add-on Asthma-Controller Therapy
David Price, F.R.C.G.P., Stanley D. Musgrave, M.D., Lee Shepstone, Ph.D., Elizabeth V. Hillyer,
D.V.M., Erika J. Sims, Ph.D., Richard F.T. Gilbert, M.R.C.G.P., Elizabeth F. Juniper, M.C.S.P.,
M.Sc., Jon G. Ayres, M.D., Linda Kemp, B.Sc., Annie Blyth, M.A., Edward C.F. Wilson, M.Sc.,
Stephanie Wolfe, M.Sc., R.G.N., Daryl Freeman, M.R.C.G.P., H. Miranda Mugford, Ph.D.,
Jamie Murdoch, Ph.D., and Ian Harvey, F.R.C.P.

N Engl J Med 2011; 364:1695-1707May 5, 2011

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

William W. Busse, M.D., Wayne J. Morgan, M.D., C.M., Peter J. Gergen, M.D., M.P.H., Herman
E. Mitchell, Ph.D., James E. Gern, M.D., Andrew H. Liu, M.D., Rebecca S. Gruchalla, M.D.,
Ph.D., Meyer Kattan, M.D., C.M., Stephen J. Teach, M.D., M.P.H., Jacqueline A. Pongracic,
M.D., James F. Chmiel, M.D., M.P.H., Suzanne F. Steinbach, M.D., Agustin Calatroni, M.S.,
Alkis Togias, M.D., Katherine M. Thompson, R.N., M.S.N., Stanley J. Szefler, M.D., and
Christine A. Sorkness, Pharm.D.

N Engl J Med 2011; 364:1005-1015March 17, 2011

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

Stephen P. Peters, M.D., Ph.D., Susan J. Kunselman, M.A., Nikolina Icitovic, M.A.S., Wendy C.
Moore, M.D., Rodolfo Pascual, M.D., Bill T. Ameredes, Ph.D., Homer A. Boushey, M.D.,
William J. Calhoun, M.D., Mario Castro, M.D., Reuben M. Cherniack, M.D., Timothy Craig,
D.O., Loren Denlinger, M.D., Ph.D., Linda L. Engle, B.S., Emily A. DiMango, M.D., John V.
Fahy, M.D., Elliot Israel, M.D., Nizar Jarjour, M.D., Shamsah D. Kazani, M.D., Monica Kraft,
M.D., Stephen C. Lazarus, M.D., Robert F. Lemanske, Jr., M.D., Njira Lugogo, M.D., Richard J.
Martin, M.D., Deborah A. Meyers, Ph.D., Joe Ramsdell, M.D., Christine A. Sorkness, Pharm.D.,
E. Rand Sutherland, M.D., Stanley J. Szefler, M.D., Stephen I. Wasserman, M.D., Michael J.
Walter, M.D., Michael E. Wechsler, M.D., Vernon M. Chinchilli, Ph.D., and Eugene R. Bleecker,
M.D. for the National Heart, Lung, and Blood Institute Asthma Clinical Research Network N
Engl J Med 2010; 363:1715-1726October 28, 2010

Original Article

Step-up Therapy for Children with Uncontrolled Asthma Receiving Inhaled

Corticosteroids

Robert F. Lemanske, Jr., M.D., David T. Mauger, Ph.D., Christine A. Sorkness, Pharm.D., Daniel
J. Jackson, M.D., Susan J. Boehmer, M.S., Fernando D. Martinez, M.D., Robert C. Strunk, M.D.,
Stanley J. Szefler, M.D., Robert S. Zeiger, M.D., Ph.D., Leonard B. Bacharier, M.D., Ronina A.
Covar, M.D., Theresa W. Guilbert, M.D., Gary Larsen, M.D., Wayne J. Morgan, M.D., Mark H.
Moss, M.D., Joseph D. Spahn, M.D., and Lynn M. Taussig, M.D. for the Childhood Asthma
Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute

N Engl J Med 2010; 362:975-985March 18, 2010

Original Article

Variants of DENND1B Associated with Asthma in Children

Patrick M.A. Sleiman, Ph.D., James Flory, Ph.D., Marcin Imielinski, M.D., Ph.D., Jonathan P.
Bradfield, B.S., Kiran Annaiah, M.Sc., Saffron A.G. Willis-Owen, Ph.D., Kai Wang, Ph.D.,
Nicholas M. Rafaels, M.S., Sven Michel, Ph.D., Klaus Bonnelykke, M.D., Ph.D., Haitao Zhang,
Ph.D., Cecilia E. Kim, B.A., Edward C. Frackelton, B.A., Joseph T. Glessner, M.Sc., Cuiping
Hou, M.Sc., F. George Otieno, M.Sc., Erin Santa, B.A., Kelly Thomas, B.A., Ryan M. Smith,
B.A., Wendy R. Glaberson, B.A., Maria Garris, B.A., Rosetta M. Chiavacci, B.S.N., Terri H.
Beaty, Ph.D., Ingo Ruczinski, Ph.D., Jordan M. Orange, M.D., Ph.D., Julian Allen, M.D.,
Jonathan M. Spergel, M.D., Ph.D., Robert Grundmeier, M.D., Ph.D., Rasika A. Mathias, Sc.D.,
Jason D. Christie, M.D., Erika von Mutius, M.D., William O.C. Cookson, M.D., Michael
Kabesch, M.D., Miriam F. Moffatt, Ph.D., Michael M. Grunstein, M.D., Ph.D., Kathleen C.
Barnes, Ph.D., Marcella Devoto, Ph.D., Mark Magnusson, M.D., Hongzhe Li, Ph.D., Struan F.A.
Grant, Ph.D., Hans Bisgaard, M.D., and Hakon Hakonarson, M.D., Ph.D.

N Engl J Med 2010; 362:36-44January 7, 2010

Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma

The American Lung Association Asthma Clinical Research Centers

N Engl J Med 2009; 360:1487-1499April 9, 2009

vol. 360 no. 15