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    PHARMACY

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    PHARMACY

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF or read online from Scribd
    Flag for inappropriate content
    4 views3 pages

    Pic

    Uploaded by

    Nadya Saptarina
    PHARMACY

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF or read online from Scribd
    Flag for inappropriate content
    of 3
    Discussion ur sadly wae designed to compare the eficacy and safey’of new oral anticeagulans Wo that of warfarin in patents with AF. Our systematic seach identified 3 vials, valuating the sew eral aaticoagulans apitaban” dabiga= tran? and ivaroxaban* In ur meta-atalys, we found that (he sew oral ancongilants dove te nk for co cd point of sek and sytem embolion compara to ‘warfarin, New orl anticoagulants were aso found to be sSvoviaed with a lower tsk fr Key sceondaryeffcacy ‘outcomes including heme ani uneatifed stoke, hem ‘rmaglesuoke, all-cause motaty, and vascular orally, Compared to warfarin. Out meteanalyis was inclusive ‘ot conclusive, may decreae the overall risk for major Dlceding events kn paints with AF. In catrast our Fesulis suggest the porslity of an increased risk for gastromtes- tina blcoding associated withthe new agent ‘Several phase Il trials have demonstrated citer a com- paraile tik or a sedesed tend of maj and clin relevant blceding assisted with the new agents compared to warfarin. Edocaban, a now factor Xa inhibitor, wes a socited with similar bleeding risks as warfarin in patients IwithAP atonce-dily dovagen he cficacy ad safety at these dosages a being investigated ina large phse I ‘ported a decreed incidence of major and clinically rl trot bleeding events in pation rosving apna Coo fal to thse rcivng walrin™ AZDXSS7. other aew {Erect thrombin nbn ha ako show tend toward lower rss for major and liically yeevant Blcding at spre deus in peste with AF“! Aiitional ston {se requied to confim thew findings and to assess the SHicny of ie matthews doae Im painter acate ‘encusthomboanbolism,dbigatan was assocated witha ncaa Tower sik formar and lineal eleva beeling compared to warfsin* Studies of aptabae and ‘ivapsabn inflict afer acute venous thembocmbo- lismsbowed comparabic risks for Heading to lew-melecs Jar weight heparm followed bya viamin K antagonist [Wis imporant to note tht polished rates of map bleding sscociated with varfarin are have been found to undeest ‘at the rik inal practic.” Thi sd tothe wndarep- ‘escalation of eller paints who have a higher Hk for ‘hajer coding eyes in clial als ‘Our sly ha 3 potenti mito. Fit there was hotewgencty attong the locked tal They examined

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