NanoCareX: Treating Fragile X Syndrome by Supplementing the FMRP Molecular Transport

Pathway with mRNA-Transporting DNA Nanorobots

References for Research

[1] Douglas, S. M., I. Bachelet, and G. M. Church. "A Logic-Gated Nanorobot for Targeted

Transport of Molecular Payloads." Science 335, no. 831 (February 16, 2012): 831-34.

doi:10.1126/science.1214081.

[2] Ettinger, Andreas, and Torsten Wittmann. "Fluorescence Live Cell Imaging." Methods in Cell

Biology 123 (2014): 77-94. doi:10.1016/b978-0-12-420138-5.00005-7.

[3] Felfoul, Ouajdi, Aaron T. Becker, Georgios Fagogenis, and Pierre E. Dupont. "Simultaneous

Steering and Imaging of Magnetic Particles Using MRI toward Delivery of Therapeutics."

Scientific Reports 6, no. 33567 (September 26, 2016): 1-10. doi:10.1038/srep33567.

[4] Fragile X Syndrome. Genetics Home Reference. April 2012.

https://ghr.nlm.nih.gov/condition/fragile-x-syndrome.

[5] Fragile X Syndrome. FragileX.org. https://fragilex.org/fragile-x/fragile-x-syndrome/.

[6] Fragile X Syndrome MedicineNet.

http://www.medicinenet.com/fragile_x_syndrome/article.htm.

[7] Hagerman, Randi, Elizabeth Berry-Kravis, Walter E. Kaufmann, Michele Y. Ono, Nicole

Tartaglia, Ave Lachiewicz, Rebecca Kronk, Carol Delahunty, David Hessl, Jeannie

Visootsak, Jonathan Picker, Louise Gane, and Michael Tranfaglia. Advances in the

Treatment of Fragile X Syndrome. Pediatrics 123, no. 1 (January 2009): 378-90.

doi:10.1542/peds.2008-0317.
 NanoCareX: Treating Fragile X Syndrome by Supplementing the FMRP Molecular Transport

Pathway with mRNA-Transporting DNA Nanorobots

[8] Howard, Brian M., Zhicheng Mo, Radmila Filipovic, Anna R. Moore, Srdjan D. Antic, and

Nada Zecevic. "Radial Glia Cells in the Developing Human Brain." The Neuroscientist 14,

no. 5 (October 2008): 459-73. doi:10.1177/1073858407313512.

[9] Kuegler, Philipp. "Markers of Murine Embryonic and Neural stem cells, Neurons and

Astrocytes: Reference Points for Developmental Neurotoxicity Testing." Altex 27 (January

2010): 16-41. doi:10.14573/altex.2010.1.16.

[10] Lubs, Herbert A., Roger E. Stevenson, and Charles E. Schwartz. "Fragile X and X-Linked

Intellectual Disability: Four Decades of Discovery." The American Journal of Human

Genetics 90, no. 4 (April 6, 2012): 579-90. doi:10.1016/j.ajhg.2012.02.018.

[11] Martin, J. P., and J. Bell. "A Pedigree Of Mental Defect Showing Sex-Linkage." Journal of

Neurology, Neurosurgery & Psychiatry 6, no. 3-4 (October 7, 1943): 154-57.

doi:10.1136/jnnp.6.3-4.154.

[12] Medication Treatments. National Institutes of Health.

https://www.nichd.nih.gov/health/topics/fragilex/conditioninfo/Pages/medicationtreatments.

aspx.

[13] Pilaz, Louis-Jan, Ashley L. Lennox, Jeremy P. Rouanet, and Debra L. Silver. Dynamic

mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing

Brain. Current Biology 26, no. 24 (December 19, 2016): 3383-92.

doi:10.1016/j.cub.2016.10.040.

[14] Testing for Fragile X. FragileX.org. https://fragilex.org/fragile-x/testing/.

 NanoCareX: Treating Fragile X Syndrome by Supplementing the FMRP Molecular Transport

Pathway with mRNA-Transporting DNA Nanorobots

[14] Torreno, Stephanie. "The History of Autism Treatment." Health Guide Info. September 24,

2010. http://www.healthguideinfo.com/autism-treatment/p88332/.

[15] Wyss Institute. DNA Nanorobot. Filmed [2012]. Vimeo video, 05:59. Posted [2012].

https://vimeo.com/36880067.