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Both wildlife and humans are at risk from pollutants in the environment, and from contamination
of the food chain. CHEM Trust is working towards a time when chemicals play no part in causing
impaired reproduction, deformities, disease, deficits in brain function, or other adverse health effects.
Human exposure to pesticides may arise from contamination of the food chain and from pesticides in
the air or in water.
CHEM Trust is committed to engaging with all parties, including regulatory authorities, scientists,
medical professionals and industry to increase informed dialogue on the harmful role of some
chemicals. By so doing, CHEM Trust aims to secure agreement on the need for better controls over
chemicals, including certain pesticides, and thereby to prevent disease and protect both humans and
wildlife.
about the
authors
Gwynne Lyons is Director of CHEM Andrew Watterson is a Professor of
Trust. She worked for many years as Health, Director of the Centre for
a pharmacist before becoming Senior Public Health and Population Health,
Researcher at Friends of the Earth in and Head of the University of Stirling’s
1987, and subsequently Toxics, Science inter-departmental Occupational and
and Policy Adviser at WWF-UK. Then Environmental Health Research Group. Previously, he was
in 2007, Gwynne set up CHEM Trust with co-director Professor of Occupational and Environmental Health at De
Elizabeth Salter-Green. She has been a member of the Montfort University, Leicester. He is a Chartered Fellow of
Health and Safety Commission’s Advisory Committee on the Institution of Occupational Safety and Health, a Fellow
Toxic Chemicals, and was a member of the UK Government’s of the Collegium Ramazzini and was a founder member of
Advisory Committee on Hazardous Chemicals from 2001- the UK Pesticides Trust – now PAN UK. He sat on the HSC
2008. CHEM Trust is a member of the UK Chemicals Chemicals in Agriculture Working Group for 10 years. He
Stakeholder Forum, and Gwynne is also currently a member has published widely on pesticides including The Pesticide
of the OECD Endocrine Disruptor Testing and Assessment Users’ Health and Safety Handbook: An International Guide,
Advisory Group. and Pesticides and Your Food. His current research interests
relate to the interface between science, policy, regulation and
In 2008, Gwynne featured in The Independent on Sunday
civil society.
list of Britain’s top 100 environmentalists as “Britain’s most
effective expert on toxic chemicals”.
CHEM (Chemicals, Health and Environment Monitoring) Trust gratefully acknowledges that this report
was produced with support from The Ecology Trust.
A full list of CHEM Trust’s reports can be found on the back cover. All are available from the CHEM Trust
website.
www.chemtrust.org.uk
Cover photos clockwise from top left, include Children running in field [Credit: iStockphoto/Maica], Spraying
orange trees [Credit: iStockphoto/Ricardo Azoury]. Woman spraying red bush [Credit: iStockphoto/brozova],
Supermarket vegetable aisle [Credit: iStockphoto/digital planet design], Tractor spraying [Credit: iStockphoto/
brytta], Farmer [Credit: iStockphoto/Forting], Pregnant mum and daughter [Credit: iStockphoto/Kemter],
Burgundy vineyard [Credit: iStockphoto/Hofmeester].
A REVIEW OF THE ROLE PESTICIDES PLAY IN SOME CANCERS:
CHILDREN, FARMERS AND PESTICIDE USERS AT RISK?
contents
Overview of the Report 2-3
Section 1: Summary of Data Linking Pesticide Exposure with Cancer 4 - 13
Farmers and agricultural workers are more likely to die from certain cancers
Childhood cancer and pesticide exposure
Table 1: Pesticides suspected of playing a role in human cancers
Explanatory notes to Table 1
Pesticides with hormone disrupting properties and cancer
Breast cancer and exposure to oestrogen-mimicking pesticides
Testicular cancer and exposure to anti-androgenic pesticides
Prostate cancer and exposure to hormone disrupting pesticides
Glossary of Abbreviations 33
Glossary of Terms 34 - 35
References 36 - 47
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A REVIEW OF THE ROLE PESTICIDES PLAY IN SOME CANCERS:
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A REVIEW OF THE
ROLE PESTICIDES PLAY
IN SOME CANCERS:
CHILDREN, FARMERS
AND PESTICIDE USERS
AT RISK?
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section 1
summary of Throughout this report, the term
‘pesticide’ is used to include
Farmers are not at increased risk of
developing cancer per se – indeed,
data linking insecticides, insect and plant growth
regulators, fungicides, herbicides,
perhaps in part because they have
historically smoked less and exercised
pesticide molluscicides, algaecides etc. Such
chemicals are designed to be toxic to
more than most people, their risk of
contracting some cancers is less. 3, 4
exposure with living organisms, so it should not be
surprising that they have been linked
Even so, it appears that exposure to
pesticides, in some situations, confers
cancer with a range of adverse health effects,
including cancer, neurological,1
a greater risk of several specific types
of cancer. For example, (and see
respiratory and dermatological also Table 1) research indicates that
diseases.2 However, this report pesticide exposure can increase the
specifically highlights the role that risk of:
pesticides are suspected of playing in • non-Hodgkin’s lymphoma (NHL);6,
some cancers. 7, 8, 9
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Table 1: Pesticides suspected of playing a role in certain human cancers as identified in epidemiological studies
examining either occupational exposures or non-occupational (environmental) exposures
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Explanatory notes to
Table 1 Some of the pesticides for which Nonylphenol, the breakdown product
epidemiological studies have raised of NPE, is an oestrogen-mimicking,
suspicions that they play a role in hormone disrupting chemical which
some cancers are outlined in Table is now found in human body fat with
1. A full systematic review of all the unknown consequences,321 although
literature on the role of pesticides there are now concerns about the
in cancer is beyond the scope of this potential role of such substances
review. Rather, the aim is primarily in breast cancer (see below). Other
to highlight epidemiological studies chemicals used in agriculture which
that raise important concerns that fall within the definition of pesticides
pesticide exposures have played an include plant growth regulators;
influential role in certain cancers. and for example, some years ago
gibberellin A3 was reported to cause
In some instances there may be cancer in animal tests.322
several studies which provide the
basis for this concern – although
there may also be other studies
that have not found an association.
Also, some of the studies included
here are considered to provide
quite preliminary data because, for
example, they may be rather small
studies or the particular pesticide
exposure may be associated with
only a relatively small increase in
the expected number of cancers. The
table should therefore be viewed with
these caveats in mind. Moreover,
some of the cancers listed in the table
comprise several different types of
cancer – so this exercise should be
regarded as providing an initial broad-
brush picture rather than a definitive
database, as narrower definitions of
certain cancers might better elucidate
those pesticides potentially involved
in causation.
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[Credit: iStockphoto/Kemter]
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Several pesticides have been found to Additive effects have been reported
have oestrogen-mimicking properties, for oestrogen-mimicking, anti-
and it is hypothesised that exposure androgenic335, 336, 337 and thyroid
to such substances add to a woman’s hormone disruptors,338 with some
total oestrogen exposure, thereby indication that there may be
increasing her risk of breast cancer. synergistic (more than additive)
When epidemiologists looked at effects in some cases.339 It is the
the total man-made oestrogenic sheer volume of contaminants with
activity in women, arising from hormone disrupting properties,
oestrogen-mimicking chemicals, to including pesticides, which raises the
see if those with higher levels of these concern that those with oestrogen-
contaminants were at greater risk of mimicking properties might be adding
breast cancer, they did indeed find to the burden of breast cancer cases.
this in leaner women.333
It should be noted that only around
Earlier epidemiological studies, one in 20 cases of breast cancer is
looking at whether certain believed to be due to genes – therefore
organochlorine pesticides were most women acquire this cancer
involved in breast cancer, did not during their lifetime. It is also clear
reveal a consistent association. They that genetic susceptibility is not the
may have missed finding a link only factor that influences breast
because they only looked at the role cancer risk, in that among women
individual substances might play, who carry the damaged BRCA1 and
rather then that played by the total BRCA2 genes – the so-called ‘breast
man-made oestrogenic burden arising cancer genes’ for women born before
from exposure to such chemicals. It is 1940 – the risk of developing breast
now well accepted that when exposure cancer by the age of 50 was 24%,
occurs simultaneously to many whereas women with these genes
hormone mimicking-chemicals, they who were born after 1940 have a
can act together and cause an ‘additive much higher risk (67%) of being
effect’, far greater than would occur diagnosed by the age of 50.340 So over
with each chemical by itself.334 time, some environmental factor(s)
are exacerbating the risk in these
genetically highly susceptible women.
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In humans, it seems that the Another study has also shown With regard to breast cancer, there
breast is particularly at risk from that when rodents are exposed to is a need to evaluate the role that
cancer-causing influences during atrazine (a herbicide) in-utero, it cumulative exposure to oestrogenic
development in the womb,341 or during causes a delay in the development pesticides and other man-made
childhood or puberty.342, 343 A study of the mammary gland in female hormone disrupting chemicals may
of girls born to women who were offspring, which is suggested to play, and it is also necessary to
misguidedly prescribed an oestrogenic confer an extended window of evaluate and assess more thoroughly
drug called diethylstilboestrol sensitivity to cancer-causing agents those chemicals which have been
(DES) during pregnancy has shown after maturity.349 In mice, it has also shown to cause mammary tumours
that they are more prone to breast been shown that dieldrin exposure in rodents. A 2007 review noted
cancer – which again highlights the of female offspring via their mothers that more than 200 such chemicals
vulnerability of the unborn child.344 during pregnancy and lactation, had been identified, including
causes mammary tumours.350 Both ten pesticides (1,2-dibromo-3-
Similarly, further research designed dieldrin351 and atrazine are considered chloropropane, atrazine, captafol,
to examine whether age at exposure to to have oestrogen-disrupting chlordane, clonitralid, dichlorvos,
contaminants plays a crucial role has properties. fenvalerate, nifurthiazole, simazine,
shown that exposure to DDT before sulfallate).352
puberty, but not after, increases Timing of exposure to contaminants
the risk of breast cancer.345 Before can therefore be seen to be crucial
birth, oestrogen levels influence the for some cancers. This means that
number of end buds in the primitive epidemiological studies that look
duct structure of the foetal breast for associations between a woman’s
tissue, with higher oestrogen levels exposure to various substances at the
inducing the growth of more end time of breast cancer diagnosis are
buds, thereby enlarging the number seriously flawed, because they miss
of cells from which cancer cells can consideration of exposure at sensitive
arise.346 In line with this, studies have time windows possibly decades earlier
shown that if rodents are exposed to in life.
an oestrogen-mimicking chemical via
their pregnant mother prior to birth,
they are far more likely to contract
mammary cancer347 when exposed
after birth to another cancer-causing
substance.348
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section 2
cancer Teasing out the role of pesticides
in cancer is difficult. The disease
Cancer Panel was concerned that
the true burden of environmentally
aetiology is known to be caused by complex
interactions of a number of factors
induced cancer had been grossly
under-estimated and highlighted
and cancer including genetics, diet, lifestyle,
stress, occupational and non-
the unacceptable burden of cancer
resulting from environmental and
prevention occupational exposures to chemicals
(including pesticides), physical
occupational exposures which could
be prevented.396
policies and biological agents, and in some
cancers, infections. Cancer causation Similarly, the European Parliament
is therefore very complex as it is has noted that cancer prevention
a multi-factorial and multi-stage is the most cost-effective response
process. and has urged that more resources
be systematically and strategically
Damage to DNA plays a role in invested in prevention. In addition,
carcinogenesis, but also important the Parliament has noted that a
is inadequate functioning of the new cancer prevention paradigm is
DNA repair mechanisms and other required to address genetic, lifestyle,
protective cellular processes. Some occupational and environmental
chemicals are not mutagenic or factors on an equal footing, and
genotoxic at low exposures, but can in a manner that reflects the
turn on or off specific genes that alter combination effects of different
a person’s susceptibility to genotoxic factors, rather than focusing on
agents or perhaps somehow affect the isolated causes. The Parliament
[Credit: iStockphoto/flashgun] progression of cancer. Some chemicals specifically mentions the role of
therefore act as epigenetic carcinogens exposure to chemical contaminants
– substances that do not themselves in food, air, soil and water, including
damage DNA, but cause alterations exposure arising from industrial
that predispose to cancer (see processes, agricultural practices or
glossary). Pesticides may thus increase the content of such substances in, for
the risk of cancer through a variety of example, construction and consumer
mechanisms including genotoxicity, products.397 (Annex 2 further discusses
tumour promotion, epigenetic effects, the role of workplace exposure and
hormonal action and immunotoxicity. environmental factors in cancer.)
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Difficulties with
epidemiological studies Given the large number of chemicals to a particular exposure may not be
to which workers and the general recognised as such at an early stage,
population are exposed, and the as happened initially with lung cancer
difficulty in acquiring good data on due to asbestos exposure. Bearing
all such exposures, epidemiological this in mind, epidemiological studies,
studies which look for associations implicating various pesticides in
can sometimes produce weak findings disease, need to be viewed cautiously,
or false positives or negatives. With as do those which have failed to
false negatives, chemicals that are confirm associations. Discrepancies
hazardous may be cleared for use, in findings may arise due to several
which will benefit chemical producers factors, including:
and users but may have potentially • chance variation;
significant adverse public health • bias in the study methods;
impacts.400, 401, 402 False positives may • confounding exposures; and
identify safe chemicals as hazardous, • differences in the quality, quantity
which will have adverse economic and timing of exposures.
effects on chemical producers. Some
researchers consider that there are a Given these difficulties, and coupled
significant number of false positive with the fact that epidemiological
epidemiological studies which have studies are always a case of ‘shutting
been too readily accepted.403 Others the stable door after the horse has
dispute this and have found few false bolted’, it is clear that to deliver
positive studies and little evidence a precautionary and preventative
of bias in favour of such studies in approach, action needs to be based on
regulatory decision-making.404 toxicity studies in the laboratory.
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section 3
regulatory
issues
[Credit: iStockphoto/Maica]
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The burden of proof Looking at the research, several studies use of potentially toxic pesticides
strongly indicate that pesticides play a would deliver such a goal, and there
role in some cancers. However, due to needs to be the political will to deliver
the many factors involved and what is this shift towards a wider preventative
often a long time-lag between exposure approach.
to causal factors and the disease
becoming apparent in humans, it will Unfortunately, changing policy or
be immensely difficult to establish with making decisions on whether there is a
a very high degree of scientific proof need to reduce exposure to a particular
that pesticide exposures play a role substance can often get tied up with
in many human cancers, particularly whether compensation should be paid
including breast, testicular and to individuals for a disease they have
prostate cancers. contracted. For example, the level of
proof required by the UK Industrial
In order to prevent cancer, it is clear Injuries Advisory Council is arbitrary
that pesticides and other chemicals and high: it generally seeks robust
need to be subjected to tough epidemiological (population-based)
regulation on the basis of laboratory evidence that the risk of the disease
studies indicating a carcinogenic is more than doubled in relation to
potential. Reducing society’s reliance certain occupational exposures before
on toxic substances will be key to it recommends that an addition to the
achieving a reduction in cancer. list of prescribed diseases for which
Therefore, putting in place policies Industrial Injuries Disablement Benefit
which seek to reduce the use of is payable (http://www.iiac.org.
harmful substances, including finding uk/). This can sometimes help skew
options that don’t require the use of the statistics on disease causation.
potentially harmful substances or by Internationally, some governments
substituting hazardous substances appear to take a more enlightened view
with less hazardous substances, will than others as to when compensation
all be part of the solution. Given the is paid to workers.410
large numbers of people exposed to
pesticides, public health considerations Given the inherent difficulties in
should be paramount and the use establishing proof of cancer causation
of potentially harmful pesticides in epidemiological studies, perhaps
minimised as soon as possible. official advisory committees should
move towards giving advice based on
Agencies around the world are now expert judgement as to the probability
acknowledging the potential benefits of that the substance in question is
reducing pesticide usage; for example, involved in certain cancers. They
it is noteworthy that the UN Food and should then try to ensure appropriate
Agriculture Organisation is promoting and meaningful application of the
Integrated Pest Management (IPM) precautionary principle, rather than,
– this is an ecosystem approach to for example, report that causality
crop production and protection that cannot be established from the
combines different management available data.
strategies and practices to grow
healthy crops minimising the use of The European Parliament, in its
pesticides. resolution of 10 April 2008 on
combating cancer in the enlarged
Geoffrey Rose, chair of epidemiology European Union, has officially
at the London School of Hygiene recognised that exposure to certain
and Tropical Medicine, noted that chemicals may be the cause of many
rather than an approach which targets cancers.411 The case for considering
people at high risk of disease, a more that chemicals, including pesticides,
powerful strategy should aim to shift play an important and preventable role
the whole distribution of a risk factor in many cancers is based on a large
in a favourable direction.409 Reducing growing body of in-vitro, animal and
overall exposures by minimising the epidemiological research.
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section 4
conclusions
and
recommendations
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Recommendations • With regard to pesticides used in • Where pesticides are used, better
agriculture, the goal should be to technologies should be developed
reduce the cancer burden and other and used in ways to limit spray
pesticide-related health effects, drift and human and non-target
while maintaining the security of organism exposures. This is because
food supplies, by giving due regard there is a need to prevent other
to integrated and sustainable pest health effects and, moreover, it can
management systems.413 be anticipated that not all pesticides
which play a part in cancer will be
• Unnecessary use of pesticides identified and eliminated from use.
should be avoided. Significant
pesticide-use reduction should • In order to protect the public, where
be achieved through integrated possible buffer zones should be
pest management, which requires established which, under proper
non-chemical options to be spraying conditions, should ensure
explored and, if chemical control no spray drift reaches homes,
is necessary, then the lowest schools and other public buildings.
risk pesticides are to be used
in a manner to reduce human • People living in houses bordering
exposure. Such a regime provides agricultural land should have a legal
opportunities for the creation of right to be notified in advance of
any pesticide spraying operations,
healthy green jobs.414
if they so request. This would give
them the option to reduce their
• An important aim must be to ensure
families’ exposure by, for example,
that current pesticides do not lead
bringing their children in from the
to cancer a decade or two hence.
garden, not hanging clothes out to
Adequate screening and testing of
dry on that day, or shutting their
chemicals must therefore ensure
windows.
that those with cancer-causing or
hormone disrupting properties are
• There should be a legal and
identified, and safer replacements
enforced duty to display notices on
found. A precautionary
footpaths before, during and after
interpretation of data is needed to
pesticide application.
identify human cancer-causing or
hormone disrupting substances.
• The use of pesticides in municipal
Due regard must also be given
and recreational settings for
to developing non-animal test
‘cosmetic’ reasons should be phased
methods that can reliably identify out, and non-chemical options
such chemicals. should always be used in public
areas, where possible.
• All EU member states should
support strict implementation of
the 2009 EU pesticides legislation,
which imposes so-called ‘cut-off’
criteria that will result in pesticides
with carcinogenic, mutagenic or
endocrine disrupting properties no
longer being approved for use.
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annex 1
EU cancer The International Agency for
Research on Cancer (IARC) estimates
Other cancers that have shown big
increasesi in Britain over the last 30
numbers that one in three Europeans is
diagnosed with cancer during their
years (1975/6 to 2005/6) include the
following:
and lifetime and one in four Europeans
dies from the disease. In 2006, in the
• Testicular cancer - doubled419
Good trend data for specific cancers Cancer rates in children have also
are available in some countries. In been rising. In Britain, incidence
Great Britain, for example, in the 30- rose by 0.8% per year on average
year period 1977 to 2006, the overall between 1962 and 1998, making a
age-standardised incidence rate for total increase of 35% (although to
cancer increased by 25%; and while what extent this increase may result
in the 10-year period of 1997-2006 from an under-diagnosis in the
the overall incidence trends remained early years is not known).426 A large
fairly constant, the highest increase analysis of trend data in 15 European
was among young people aged 15 to countries found a similar annual
34.416 percentage increase of 1.1% for the
period 1978-1997. It was concluded
The cancers that have increased that the increased incidence could
dramatically should be the focus only partly be explained by changes in
of particular attention. Some have diagnostic methods and registrations,
some well known causal factors, and that the magnitude of the increase
including melanoma of the skin (sun suggested that other factors – changes
exposure), lung cancer (where the in life circumstances and exposure
increase is in women smokers), liver to a variety of agents, for example
cancer (alcohol) and mesothelioma – had contributed to the increase in
(asbestos). Prostate cancer also seems childhood cancer.427
to have undergone a real increase,
although a large proportion of the Within the total increase in childhood
reported tripling in incidence during cancer in Britain between 1962 and
the last 30 years417 is thought to be 1998, there were differences in trends
[Credit: iStockphoto/brozova]
due to better diagnostic techniques.418 between various cancers. For example,
from 1963 to 1997 the average annual
increase was 0.6% per year for
leukaemias and lymphomas, 1% for
brain and spinal tumours and 1.4% for
bone and soft tissue sarcomas.428
i
It should be noted that these increases are not due to population ageing, as cancer rates are age adjusted.
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annex 2
introduction to
chemicals
causing
cancer,
susceptible
windows of
exposure, and
occupation-
related cancers
Chemicals causing cancer Many chemicals are known to cause of all cancers, this would amount to
cancer. For example, it is well known some 11,500 cancers a year in the EU
that smoking cigarettes or exposure – which shows the potential benefits
to asbestos, benzene, arsenic or vinyl of better pesticide regulation.
chloride increase a person’s chances
of getting certain cancers. Identifying which chemicals
(particularly which pesticides) can
Since 1971, more than 900 agents cause cancer should be an important
and chemicals have been evaluated part of any cancer prevention strategy.
for their ability to cause cancer, some There is currently much research
400 of which have been identified by into which genes may make a person
the International Agency for Research more susceptible to cancer. Perhaps
on Cancer (IARC) as carcinogenic or what deserves more attention is
potentially carcinogenic to humans.429 which chemicals can cause cancer,
However, with thousands of chemicals which carcinogenic exposures are
traded in volumes of over 100 tonnes preventable, and during what time of
a year, many of which have not been life people are particularly susceptible
thoroughly tested, it can reliably to carcinogens.
be predicted that many chemicals
which cause cancer have not yet been
identified.
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For example, the research was largely Leaving aside the difficulties of Occupational exposures of adults
based on studies of workers with high acquiring good data on the role tend to be more studied than
exposure to known or likely human occupational exposures play in cancer, those of the general public, and
carcinogens and it disregarded the exposures in the wider environment therefore this review includes several
widespread low exposures to human also play an important part. However, epidemiological studies of pesticide
carcinogens, exposures to suspected what proportion of cancer cases manufacturers and farm workers.
carcinogens without good human might, in addition, be caused by However, we know that ‘quadruple
data, and general air pollution. Some chemical exposures in the population jeopardy’ will apply to many exposed
experts have noted that the HSE at large is even more difficult to to pesticides, in terms of pesticide
figure of 4.9% is likely to be a gross determine – not least because it’s exposures at work (eg. pest control in
underestimation, not only due to at present impossible to evaluate offices), leisure (eg. pesticides used
these limitations, but also because the with accuracy what role low-level in the country or on sports fields), in
HSE work did not take into account exposures play in the development the home (eg. pesticides on carpets,
the effects of simultaneous exposures of cancer. Nevertheless, according to fabrics and pets) and for example, via
to certain compounds. Nor did it the American Cancer Society, “there food.457
consider ‘unknown’ carcinogens – and is reason to be concerned about
certainly many chemicals have not low-level exposures to carcinogenic Studies of families on farms may
been adequately tested for their ability pollutants because of the multiplicity provide more useful data because
to cause cancer.454 of substances, the involuntary nature these are more likely to capture
of many exposures, and the potential vulnerable windows of exposure, and
Other flaws in the HSE’s estimate that even low-level exposures because pregnant mothers and young
will arise because there are many contribute to the cancer burden when children will be exposed via pesticide
methodological challenges, large numbers of people are exposed”. residues that find their way into their
particularly in terms of estimating Expressing similar concerns, the US home.458 A large study of farming
exposed populations in agriculture, President’s Cancer Panel noted the families in the US is now shedding
horticulture, forestry and gardens, growing body of evidence linking light on some of the long term-health
estimating exposures, and environmental exposures to cancer, concerns associated with farming.
attributing the risks. Even where which had hitherto been grossly This initiative, the Agricultural Health
known carcinogens are used in UK underestimated.456 Study, has 89,000 participants,
workplaces, there are inaccurate including farming families and
estimates of those exposed and weak Concerns about the role of pesticides professional sprayers. It is sponsored
control standards may be ineffectively in cancer arise not only because by the US National Institutes of
or never enforced, especially in small of their toxicity, but also because Health (specifically the National
and medium-sized enterprises. their diffuse use (on crops grown Cancer Institute and the National
on farms, on animals used for meat Institute of Environmental Health
The UK also lacks a comprehensive and milk production, on allotments Sciences) and the Environmental
list of occupational and wider or in the garden and on pests in the Protection Agency, with the work
environmental carcinogens. home) means there is potential for being done at the University of Iowa
This means populations exposed widespread exposure of susceptible and Battelle Centers for Public Health
to carcinogens, the number of populations from spray drift, Research and Evaluation. Children in
carcinogens they are exposed to, and contamination of soil, water and general may be particularly vulnerable
the years of exposure to carcinogens the indoor environment, and from to the effects of pesticide exposure,
that may occur in those working up food chain contamination. These and it also seems that they may be
to and beyond 65, can all be seriously vulnerable people include the elderly, exposed to higher levels of certain
under-estimated. In an attempt to pregnant women and pre-pubertal pesticides than adults in the general
rectify the under-estimation that children. public.459
is considered to exist, some public
health experts believe that, for
example, one in five UK workers is
exposed to carcinogens.455
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annex 3
identifying To secure cancer prevention,
chemicals which cause the
The European Commission has now
created a list of approved active
pesticides disease need to be identified so
that they can be prevented from
substances and member states may
authorise only plant protection
causing being marketed in the first place.
However, the unfortunate reality
products containing such substances
(a database is available on the
cancer, and is that many industrial chemicals
have not been tested before being
European Commission website).462
Even so, concern remained that some
EU legislation widely brought into use, and others pesticides warrant better regulation
on pesticides
have not been adequately tested. – which is why new legislation on
The new EU REACH legislation pesticides, outlined below, was agreed
(Regulation 1907/2006 concerning in 2009.
the Registration, Evaluation,
Authorisation and Restriction of Currently, to test for the cancer-
Chemicals) for industrial chemicals causing properties of a substance, the
is now being implemented – but even primary experimental approach is
so, it will only require substances to expose rats and mice to relatively
produced above certain tonnages to be high doses of the substance for a
tested for carcinogenicity. couple of years. The vast majority
of substances that are carcinogenic
Previously, many pesticides had in humans are also carcinogenic in
also been inadequately tested for laboratory animals,463 so relying on
their cancer-causing properties animal tests is a useful option in
prior to marketing. For example, some cases until equally robust non-
in 1991 in the US National Cancer animal test methods are available.
Institute and the National Toxicology However, as noted earlier, a problem
Programme, only 47 pesticides had with these test methods is that they
been tested on rodents, with evidence do not include the period during
of carcinogenicity for half of these.460 development in-utero, although
In the EU, a similar ‘catch-up’ testing there is evidence that this would
programme was brought in as laid increase the sensitivity with which
down in Directive 91/414/EEC, and cancer-causing agents could be
by March 2009, this pesticide review detected. Some fast and cheap in-
programme was eventually completed. vitro test methods which can identify
About 1,000 existing pesticides on the genotoxicants are already available.
[Credit: iStockphoto/Radiant Byte] market prior to 1993 were subject to
this review programme, but only some To minimise animal testing,
250 passed the harmonised EU safety developing and implementing
assessment. Most substances (67%) non-animal test methods to reliably
were eliminated because dossiers were identify cancer-causing substances
either not submitted, were incomplete should be a priority.
or were withdrawn by the industry.
About 70 substances failed the review
and were removed from the market,
because evaluation showed they were
not safe enough for use.461
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EU Pesticides Regulation
1107/2009 The new EU Plant Protection Products reasonable means (see Preamble 32 &
Regulation (EC No 1107/2009)464 Art 4(7) & Art 53). Furthermore, there
seeks to protect human health and are transitional provisions, whereby
wildlife. It will be used to eliminate existing approvals are valid for 5-10
exposure to pesticides which are years following the date when they
PBT (persistent, bioacccumulative were granted under earlier legislation
and toxic), vPvB (very persistent and (Directive 91/414/EEC – see Article
very bioaccumulative), persistent 80). So not all pesticides with such
organic pollutants (POPs), mutagenic, undesirable properties will come
carcinogenic, or have endocrine under the hammer straight away.
disrupting properties. This new
Regulation applies from 14 June The Regulation stipulates that use of
2011, and brings in so-called ‘cut-off a pesticide will not be allowed if it has
criteria’ for pesticides with certain endocrine disrupting properties that
properties. Specific cut-off criteria may cause adverse effects in humans,
include: unless human exposure is negligible.
Similarly, the pesticide will not be
• mutagens Category 1A or 1B;
allowed if it has endocrine disrupting
• carcinogens Category 1A or
properties that may cause adverse
1B, unless human exposure is
effects on non-target organisms,
negligible;
unless their exposure to that active
• reproductive toxicants Category 1A
substance is negligible (see Annex II,
or 1B, unless human exposure is
3.8.2).
negligible; and
• pesticides with endocrine disrupting
However, the Regulation does not
properties, unless human exposure
provide specific scientific criteria
is negligible.
for the assessment and decision on
(See Annex 4 for explanation of
which substances can be judged to
Categories).
have endocrine disrupting properties.
Such criteria are to be presented
It is therefore expected that several
by the European Commission by
pesticides will, in future, no longer be
mid-December 2013. Until such time
approved for use.
as criteria for endocrine disruption
are brought forward, any pesticide
There have been some alarmist
classified as a Category 2 carcinogen
claims about the consequences of
(C2) and a Category 2 reproductive
this new Regulation – that it will
toxicant (R2) or R2 with toxic
threaten crop yields, lead to increased
effects on the endocrine organs, will
food prices,465 and will result in the be considered to have endocrine
inability to grow some crops in certain disrupting properties.
parts of the EU.466, 467 However, the
Regulation ensures that where there Relevant parts of Annex 2 of the
are valid concerns about there being text of the Regulation (1107/2009)
no alternative to contain a threat to are reproduced below, and it
crops, exceptions can be made. can be seen that the provisions
apply to all substances in the
It allows temporary authorisation pesticide formulation, not just the
of pesticides not complying with active ingredient. Annex 4 of this
provisions related to endocrine report provides extracts from the
disrupting properties or suspected classification and labelling legislation
cancer-causing properties (provided and explains the definitions and
there is a threshold for effects) categories of mutagens, carcinogens
because of a danger or threat to plant and reproductive toxicants.
production or ecosystems which “3.6.2. An active substance, safener
cannot be contained by any other
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EU Pesticides Regulation
1107/2009
(cont)
or synergist shall only be approved of reproductive toxicity testing synergist concerned on food and
if, on the basis of assessment of carried out in accordance with the feed do not exceed the default value
higher tier genotoxicity testing data requirements for the active set in accordance with point (b) of
carried out in accordance with the substances, safeners or synergists Article 18(1) of Regulation (EC) No
data requirements for the active and other available data and 396/2005.
substances, safeners or synergists information, including a review of
and other available data and the scientific literature, reviewed By 14 December 2013, the
information, including a review of by the Authority, it is not or has Commission shall present to
the scientific literature, reviewed by not to be classified, in accordance the Standing Committee on the
the Authority, it is not or has not to with the provisions of Regulation Food Chain and Animal Health a
be classified, in accordance with the (EC) No 1272/2008, as toxic for draft of the measures concerning
provisions of Regulation (EC) No reproduction category 1A or 1B, specific scientific criteria for
1272/2008, as mutagen category 1A unless the exposure of humans the determination of endocrine
or 1B. to that active substance, safener disrupting properties to be adopted
or synergist in a plant protection in accordance with the regulatory
3.6.3. An active substance, safener product, under realistic proposed procedure with scrutiny referred to
or synergist shall only be approved, conditions of use, is negligible, that in Article 79(4).
if, on the basis of assessment of is, the product is used in closed
carcinogenicity testing carried systems or in other conditions Pending the adoption of these
out in accordance with the data excluding contact with humans criteria, substances that are
requirements for the active and where residues of the active or have to be classified, in
substances, safener or synergist substance, safener or synergist accordance with the provisions of
and other available data and concerned on food and feed do Regulation (EC) No 1272/2008, as
information, including a review of not exceed the default value set carcinogenic category 2 and toxic
the scientific literature, reviewed in accordance with point (b) of for reproduction category 2, shall
by the Authority, it is not or has Article 18(1) of Regulation (EC) No be considered to have endocrine
not to be classified, in accordance 396/2005. disrupting properties.
with the provisions of Regulation
(EC) No 1272/2008, as carcinogen 3.6.5. An active substance, safener In addition, substances such
category 1A or 1B, unless the or synergist shall only be approved as those that are, or have to be
exposure of humans to that active if, on the basis of the assessment classified, in accordance with
substance, safener or synergist in of Community or internationally the provisions of Regulation
a plant protection product, under agreed test guidelines or other (EC) No 1272/2008, as toxic for
realistic proposed conditions of use, available data and information, reproduction category 2 and which
is negligible, that is, the product is including a review of the scientific have toxic effects on the endocrine
used in closed systems or in other literature, reviewed by the organs, may be considered to
conditions excluding contact with Authority, it is not considered have such endocrine disrupting
humans and where residues of to have endocrine disrupting properties.”
the active substance, safener or properties that may cause adverse
synergist concerned on food and effect in humans, unless the
feed do not exceed the default value exposure of humans to that active
set in accordance with Article 18(1) substance, safener or synergist in
(b) of Regulation (EC) No 396/2005. a plant protection product, under
ii
realistic proposed conditions of use,
3.6.4. An active substance, safener is negligible, that is, the product is
or synergist shall only be approved used in closed systems or in other
if, on the basis of assessment conditions excluding contact with
humans and where residues of
the active substance, safener or
ii
The default value set in accordance with point (b) of Article 18(1) of Regulation (EC) No. 396/2005 is 0.01 mg/kgfood.
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Just how many pesticide active that are yet to be agreed, although hazardous properties, rather than
ingredients might be impacted a subsequent summary impact just a formal individual pesticide
by the cut-off criteria for CMRs assessment has been published. risk assessment approach, has been
and endocrine disruptors in this (see http://www.pesticides.gov.uk/ adopted.
new Regulation is not known uploadedfiles/Web_Assets/PSD/
with certainty, but an initial study Outcomes_paper_-_summary_ There are likely to be considerable
suggested it might be around 7%. impact_assessment_(Jan_09).pdf). financial and health benefits from
For example, the Swedish Chemicals more tightly regulating pesticides by
Agency (KEMI) examined 271 active The names of chemicals (including ensuring that, where necessary, safer
substances and considered that seven pesticides) known or suspected to substitutes are used. Such benefits will
met the criteria for CMRs and fifteen have endocrine disrupting properties accrue not just with respect to cancer
might be considered to be endocrine can also be found in reports on the reduction. For example, a World Bank
disruptors, with some overlap between European Commission’s website.iii study471 estimated that in developed
the two, such that this was nineteen The EC now has a list of around 200 countries, pollution from agro-
pesticides in total. Those listed as substances which show clear evidence industrial chemicals and chemical
potentially meeting the cut-off criteria of endocrine disrupting effects. pollution from diffuse sources caused
for both their CMR and endocrine Given the possibility of additive around 1.5% (that is between 0.6%
disrupting properties include linuron, effects from simultaneous exposure and 2.5%) of the total disease burden
flusilazole and flurprimidol. Those to several hormone disrupting (deaths and general ill health).
listed for just their CMR properties chemicals, any exposure – even to
are glufosinate, carbendazim, low levels of a particular hormone The financial and health benefits
dinocap and flumioxazin, while those disrupting pesticide – might be from banning certain pesticides are
listed for their endocrine disrupting expected to potentially contribute not easy to attribute because of the
properties are amitrole, ioxynil, to an effect. Therefore, it would be difficulty in establishing causation of
molinate, tepralozydim, tralkoxydim, wise to ensure the EU legislation is health effects. Nevertheless, a study
epoxiconazole, iprodione, mancozeb, strictly implemented in order to try commissioned by the UK Pesticides
maneb, metconazole, tebuconazole to eliminate exposure to hormonally Safety Directorate estimated the
and thiacloprid.468 However, this active pesticides. Indeed, the new potential benefits of banning just
assessment should not be taken as a Regulation requires that cumulative seven active pesticide ingredients to
definitive. effects are considered, and for be at least somewhere in the region
example, that residues should of £93 -186 million as a result of
In December 2008, the UK Pesticides avoiding cancer in spray operators
Safety Directorate published an “not have harmful effects on human alone, and perhaps up to as much as
update of their earlier assessment of health, including that of vulnerable £354 -709 million in the case of the
a selection of almost 300 pesticide groups, or animal health, taking most exposed farm workers over 30
active ingredients, and identified into account known cumulative years.472 Blainey et al (2008) noted
those which might be caught and synergistic effects where the that if these figures were scaled up
by various cut-off criteria. This scientific methods accepted by the to apply to the EU, which is roughly
suggested that a greater number of Authority to assess such effects are eight times the size of the UK, the
pesticides might be impacted.469 In available, or on groundwater.” benefits of withdrawing approvals for
2008, another impact assessment (Article 4(2)(a)) those substances could be as much as
(Blainey et al.) was also published €3,568 - 7,160 billion over 30 years
and this outlined an amalgamated The reality is that exposure to in the case of the maximum exposed
list of pesticides which might not be endocrine disrupting chemicals from farm population.473 Such estimates
approved for use in future, based on all sources, not just pesticides, might illustrate that the new pesticides
the assessments of the UK Pesticides contribute to cumulative effects. legislation has the potential not only
Safety Directorate and environmental Exposure to multiple chemicals by to alleviate much suffering, but also
non-governmental organisations. multiple routes needs to be taken into provide significantly reduced health
However, the impact of the Regulation account, and given the complexity of spending due to a reduction in the
will ultimately depend on the scientific this, the practical option of regulating burden of cancer.
criteria for the determination of pesticides on the basis of certain
endocrine disrupting properties iii
http://ec.europa.eu/environment/endocrine/strategy/substances_en.htm
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annex 4
classification Table 2: Hazard categories for germ cell mutagens
EU
CATEGORY 1 Substances known to induce heritable mutations or to be
regarded as if they induce heritable mutations in the germ
cells of humans.
Category 1A
Substances known to induce heritable mutations in the
germ cells of humans. The classification in Category 1A is
based on positive evidence from human epidemiological
Category 1B studies.
For the purposes of the EU pesticides For the purpose of classification for
legislation, the definition and germ cell mutagenicity, substances
categorisation of carcinogenic, are allocated to one of two categories
mutagenic and reproductive toxicant shown in Table 2. Test results
(CMR) substances are laid down in are considered from experiments
EU Regulation (EC) No 1272/2008 on determining mutagenic and/or
classification, labelling and packaging genotoxic effects in germ and/or
of substances.474 somatic cells of exposed animals. (The
germ cells are the cells which give
A crucial element for assessing the rise to the gametes – sperm and eggs
predictive value of rodent tumours for – while the somatic cells are other
human cancer hazard is whether data cells in the body.) Mutagenic and/or
are adequate to exclude a genotoxic genotoxic effects determined in in-
mode of action. vitro tests are also considered.
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Categories Criteria
CATEGORY 1 Known or presumed human carcinogens
A substance is classified in Category 1 for carcinogenicity
on the basis of epidemiological and/or animal data. A
Category 1A substance may be further distinguished as:
A carcinogen is a substance or a Reproductive toxicity includes adverse Adverse effects on sexual function
mixture of substances which induces effects on sexual function and fertility and fertility includes, but is not
cancer or increases its incidence. in adults, as well as developmental limited to, alterations to the female
Substances which have induced toxicity in offspring. In this and male reproductive system,
benign and malignant tumours in classification system, reproductive adverse effects on onset of puberty,
well performed experimental studies toxicity is subdivided under two main gamete production and transport,
on animals are considered also to headings: reproductive cycle normality, sexual
be presumed or suspected human • adverse effects on sexual function behaviour, fertility, parturition,
carcinogens unless there is strong and fertility; and pregnancy outcomes, premature
evidence that the mechanism of • adverse effects on development of reproductive senescence, or
tumour formation is not relevant the offspring. modifications in other functions
for humans. For the purpose of
that depend on the integrity of the
classification for carcinogenicity, For the purpose of classification, the reproductive systems.
substances are allocated to one of hazard class Reproductive Toxicity is
two categories based on strength differentiated into: Adverse effects on development of the
of evidence and weight of evidence
• adverse effects offspring includes any effect which
considerations. These are shown in
- on sexual function and fertility, or interferes with normal development
Table 3.
- on development; of the baby, either before or after
• effects on or via lactation. birth, and results from exposure of
either parent prior to conception, or
exposure of the developing offspring
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Categories Criteria
CATEGORY 1 Known or presumed human reproductive toxicant.
toxicity is considered together, such
Substances are classified in Category 1 for reproductive as epidemiological studies and case
toxicity when they are known to have produced an adverse reports in humans, and reproduction
effect on sexual function and fertility, or on development
in humans, or when there is evidence from animal
studies along with sub-chronic,
studies, possibly supplemented with other information, chronic and special study results
to provide a strong presumption that the substance has in animals that provide relevant
the capacity to interfere with reproduction in humans.
The classification of a substance is further distinguished
information regarding toxicity to
on the basis of whether the evidence for classification is reproductive and related endocrine
Category 1A primarily from human data (Category 1A) or from animal organs.
data (Category 1B).
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glossary of
abbreviations CIS
Carcinoma in situ is an early form of cancer.
’In situ’ means it is before any invasion of the surrounding
tissue.
CMR Carcinogen, mutagen and/or reproductive toxicant
DDT Dichloro diphenyl trichloroethane, a persistent insecticide,
now banned. Commercial DDT is a mixture of several closely
related compounds. The major component (77%) is the
pp isomer but the o,p’ isomer is also present in significant
amounts (15%).
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A REVIEW OF THE ROLE PESTICIDES PLAY IN SOME CANCERS:
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glossary of
terms Active ingredient
The substance in a pesticide
Carcinogen
A substance or a mixture of
formulation that is biologically active substances which induces cancer or
as a pesticide. increases its incidence.
Aromatase Clastogen
An enzyme involved in the production A substance that can cause breaks in
of oestrogen that acts by catalysing chromosomes, leading to sections of
the conversion of testosterone the chromosome being altered. This
(an androgen) to oestradiol (an is a form of mutagenesis and can lead
oestrogen). Aromatase is located to carcinogenesis, as cells that are not
in oestrogen-producing cells in the killed by the clastogenic effect may
adrenal glands, ovaries, placenta, become cancerous.
testicles, adipose (fat) tissue, and
brain. Co-carcinogen
A chemical that promotes the effects
Biocides of a carcinogen in the production of
In the EU, biocidal products are cancer. Usually, the term refers to
defined as “active substances and chemicals that are not carcinogenic
preparations containing one or more on their own. A chemical can be co-
active substances, put up in the form carcinogenic with other chemicals or
in which they are supplied to the user, with non-chemical carcinogens, such
intended to destroy, deter, render as UV radiation.
harmless, prevent the action of or
otherwise exert a controlling effect on Dioxins
any harmful organism by chemical Polychlorinated dibenzodioxins
or biological means.” (PCDDs). Dioxins are unwanted by-
products of combustion, and they may
The scope of the EU biocidal products be found as a contaminant in certain
directive is very wide, with four chlorinated compounds.
main groups containing 23 different
product types. The four main groups DNA
are: (i) disinfectants - for home and DNA (Deoxyribonucleic acid) is a
industrial use; (ii) preservatives - for nucleic acid that contains the genetic
manufactured and natural products; instructions used in the development
(iii) pest control products; and and functioning of all known living
(iv) other biocidal products, e.g. organisms. The main role of DNA
vertebrate control and other molecules is the long-term storage
specialised products. In the EU, of information, and as such it is
‘biocide’ does not, however, include considered to be the blueprint,
plant protection products, human containing the instructions needed
medicines, veterinary medicines, to construct other components of
medical devices or cosmetics. cells such as proteins and other
Therefore plant protection products, molecules. The DNA segments that
such as herbicides and insecticides, carry this genetic information are
are regulated separately from called genes, and within cells, DNA is
biocides. (However, see below under organised into long structures called
Pesticides - throughout this report, chromosomes.
the term pesticides includes plant
protection products and biocides). EDCs
The term ‘endocrine disrupting
chemicals’ is interchangeable with
‘hormone disrupting chemicals’ or
34
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A REVIEW OF THE ROLE PESTICIDES PLAY IN SOME CANCERS:
CHILDREN, FARMERS AND PESTICIDE USERS AT RISK?
48
A REVIEW OF THE ROLE PESTICIDES PLAY IN SOME CANCERS:
CHILDREN, FARMERS AND PESTICIDE USERS AT RISK?
All CHEM Trust briefings and reports can be downloaded from www.chemtrust.org.uk
Previous publications include: i) What could new EU chemicals legislation deliver for public health?
outlining the health benefits that the new EU Regulation (REACH) could
provide (2007).
iv) Factors influencing the risk of breast cancer – established and emerging
– a briefing for the public on the potential role of chemicals in breast
cancer (2008).
vii) Male reproductive health disorders and the potential role of exposure
to environmental chemicals by Professor Richard Sharpe of the Medical
Research Council (2009).
viii) Men under threat: The decline in male reproductive health and the
potential role of exposure to chemicals during in-utero development –
a fully referenced briefing by Gwynne Lyons (2009).
x) Why mollusc toxicity tests for endocrine disruptors and other chemicals
are needed - A briefing for policy makers re testing chemicals for their
toxic properties (2009).