V.

PATHOPHYSIOLOGY

Post-streptococcal infection
(group-A, beta hemolytic)

Release of material from the organism,

into the circulation (antigen)

Formation of antibody

Immune complex reaction in the

glomerular capillary

Inflammatory response

Proliferation of epithelial cells lining

glomerolus & cells between
endothelium & epithelium of capillary
membrane

Swelling capillary membrane &

infiltration with leukocytes

Permeability of base membrane

 Occlusion of the capillaries of the
glomeruli vasospasm of afferent
ventrioles

Glomerular filtration rate

Ability to form filtrate from

glomeeruli plasma flow

Retention of H2O & Na; hypovolemia;

circulatory congestion

Edema
Hypertension
urinary output
Urine dark in color
Anorexia
Irritability lethargy

ACUTE
GLOMERULO-
NEPHRITIS